Patents Represented by Attorney, Agent or Law Firm Lisa A. Haile, Ph.D.
  • Needle electrode assembly for electroporation mediated delivery of genes and drugs
    Patent number: 6418341
    Abstract: A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: July 9, 2002
    Assignee: Genetronics, Inc.
    Inventors: Gunter A. Hofmann, Richard A. Gilbert, Richard Heller, Mark J. Jaroszeski
  • Method for production of neuroblasts
    Patent number: 6265175
    Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblast and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: July 24, 2001
    Assignee: The Regents of the University of California
    Inventors: Fred H. Gage, Jasodhara Ray
  • Method of using hedgehog polypeptides to regulate neuronal cell growth
    Patent number: 6214794
    Abstract: The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a Gly↓Cys Phe site recognized by the autoproteolytic domain in the native protein. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. Also provided are methods of use of the N and C fragments.
    Type: Grant
    Filed: October 7, 1996
    Date of Patent: April 10, 2001
    Assignees: The Johns Hopkins University School of Medicine, University of Washington
    Inventors: Philip A. Beachy, Randall T. Moon, Jeffrey A. Porter
  • Method of detection of congenital disease
    Patent number: 6183975
    Abstract: A method for diagnosing a congenital disease by determining a cell's response to activation of a membrane receptor using a physiological indicator is provided. The method of the invention uses fetal or adult cells in a non-invasive screen for congenital disorders.
    Type: Grant
    Filed: February 24, 1998
    Date of Patent: February 6, 2001
    Inventors: J. Jay Gargus, Mark Estacion
  • Method for production of neuroblasts
    Patent number: 6013521
    Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: January 11, 2000
    Assignee: University of California
    Inventors: Fred H. Gage, Jasodhara Ray