Abstract: Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.
Type:
Grant
Filed:
June 23, 2000
Date of Patent:
December 14, 2004
Assignee:
BASF Aktiengesellschaft
Inventors:
Markus Pompejus, Burkhard Kröger, Hartwig Schröder, Oskar Zelder, Gregor Haberhauer
Abstract: Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SRT proteins, mutated SRT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SRT genes in this organism.
Type:
Grant
Filed:
June 23, 2000
Date of Patent:
November 23, 2004
Assignee:
BASF Aktiengesellschaft
Inventors:
Markus Pompejus, Burkhard Kroger, Hartwig Schröder, Oskar Zelder, Gregor Haberhauer, Heung-Shick Lee, Hyung-Joon Kim
Abstract: The present invention provides for crystalline cPLA2. The crystal structure of cPLA2 has also been solved using such material. Models based upon such crystal structure are also provided. Methods of identifying inhibitors of cPLA2 activity and membrane binding using such models are also disclosed.
Type:
Grant
Filed:
February 15, 1999
Date of Patent:
October 5, 2004
Assignee:
Genetics Institute, LLC
Inventors:
Andrea Dessen, William S. Somers, Mark L. Stahl, Jasbir S. Seehra
Abstract: The present invention is based at least in part on the discovery of polymorphisms within the 5-lipoxygenase gene which are included in a haplotype. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of a 5-LO gene. The invention also provides methods for identifying specific alleles of polymorphic regions of a 5-LO gene, methods for determining whether a patient has a more or less severe phenotype of an inflammatory disease or disorder such as asthma, methods for determining whether a patient will be more or less responsive to treatment with 5′LO inhibitors, forensic methods based on detection of polymorphisms within the 5-LO gene, and kits for performing such methods.
Abstract: An animal, e.g., transgenic mouse, in which the MSH4 gene is misexpressed. The animal is useful for screening treatments for a number of conditions. Methods for identifying contraceptive agents are also described.
Type:
Grant
Filed:
November 21, 2001
Date of Patent:
September 21, 2004
Assignees:
Wyeth, Albert Einstein College of Medicine of Yeshiva
University
Inventors:
Jeffrey W. Pollard, Winfried Edelmann, Paula E. Cohen, Burkhard Kneitz, Panos Stevis, Raju S. Kucherlapati