Abstract: The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.
Type:
Grant
Filed:
November 24, 2004
Date of Patent:
March 23, 2010
Assignee:
Whitehead Institute for Biomedical Research
Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
Type:
Grant
Filed:
December 17, 1999
Date of Patent:
May 20, 2003
Assignee:
Affymetrix, Inc.
Inventors:
Stephen P. A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung