Patents Represented by Attorney Lois K. Winston

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  • Carbamazepine derivatives
    Patent number: 5688944
    Abstract: The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having the general formula ##STR1## The present invention also provides a novel carbamazepine acid compound suitable for attachment to proteins for the production of carbamazepine immunogens. The carbamazepine antigen of the present invention has the following general structure: ##STR2## where X is C.dbd.O, CH.sub.2 or SO.sub.2 ; Y is C.dbd.O, CH.sub.2, SO.sub.2 ; R is an alkyl and P is a protein or a hapten.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 18, 1997
    Assignee: Dade International Inc.
    Inventor: Chengrong Wang
  • Factor IX chromogenic assay
    Patent number: 5627038
    Abstract: A chromogenic assay for determination of blood coagulation Factor IX (christmas factor) utilizes Factor Xa formed by the conversion of Factor X by activated Factor IX and Factor VIII to cleave a chromogenic substrate. The sample is combined into a mixture with Factor XIa in the presence of Factor IIa (thrombin), incubated, combined with Factor X and Factor VIII, and incubated. A thrombin inhibitor, and an indicator agent which reacts with Factor Xa, are added and the resulting signal measured and correlated to the level of Factor IX in the sample.
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: May 6, 1997
    Assignee: Dade International Inc.
    Inventor: H. C. Hemker
  • Avidin-binding fluorescing and quenching reagent for use in homogeneous assays
    Patent number: 5612221
    Abstract: Avidin-binding azo reagents which alter the spectrophotometric properties of avidin and the use of such reagents in homogeneous assays are described.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: March 18, 1997
    Assignee: Dade Chemistry Systems Inc.
    Inventors: Donald M. Simons, Susan Y. Tseng, Patricia C. Weber
  • Tetrahydroxyquinone as an activator component for activated partial thromboplastin time test of blood coagulation
    Patent number: 5550028
    Abstract: The compound 2,3,5,6-tetrahydroxy-1,4-quinone, its derivatives and structural analogs are used as activators for intrinsic blood coagulation and as diagnostic reagents for the activated partial thromboplastin time test of blood coagulation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 27, 1996
    Assignee: Dade International Inc.
    Inventors: Ted C. K. Lee, Franz H. Pelzer, Leslie A. Motley
  • Method of making a blood gas/electrolyte control
    Patent number: 5518929
    Abstract: Aqueous solutions containing buffers and electrolytes are adjusted to levels required for calibration of both blood gas analyzers and ion selective electrolyte analyzers. A control material, composed of similar matrix, is adjusted to three levels of blood gas and electrolyte conditions. These quality control materials are used to monitor blood gas/electrolyte laboratory instrumentation.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: May 21, 1996
    Assignee: Dade International Inc.
    Inventor: Kathryn D. Herring
  • Method and composition for determining antimicrobial susceptibility of the majority clinically significant Gram postitive organism
    Patent number: 5457030
    Abstract: This invention relates to a method to determine susceptibility to antimicrobial agents of a majority of clinically significant Gram positive organisms. This invention also relates to a mixture of fluorogenic substrates used to detect the growth of Gram positive bacteria.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: October 10, 1995
    Assignee: MicroScan, Inc.
    Inventors: Robert Badal, Roger Kelley, Theodore T. Sand, Shoshana Bascomb
  • Blood gas/electrolyte calibrator and quality controls
    Patent number: 5422278
    Abstract: Aqueous solutions containing buffers and electrolytes are adjusted to levels required for calibration of both blood gas analyzers and ion selective electrolyte analyzers. A control material, composed of similar matrix, is adjusted to three levels of blood gas and electrolyte conditions. These quality control materials are used to monitor blood gas/electrolyte laboratory instrumentation.
    Type: Grant
    Filed: June 1, 1994
    Date of Patent: June 6, 1995
    Assignee: Dade International Inc.
    Inventor: Kathryn D. Herring