Patents Represented by Attorney Loretta J. Sauermelch

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  • Calcilytic compounds
    Patent number: 7829594
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: November 9, 2010
    Assignee: GlaxoSmithKline, LLC
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • Chemical compounds
    Patent number: 7691893
    Abstract: The present invention relates to (1S,6R)-6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane, pharmaceutically acceptable salts, prodrugs or solvates thereof; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as serotonin (5-HT), dopamine (DA) and norepinephrine (NE), re-uptake inhibitors.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: April 6, 2010
    Assignee: Glaxo Group Limited
    Inventor: Romano Di Fabio
  • Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
    Patent number: 7534793
    Abstract: Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: May 19, 2009
    Assignee: SmithKline Beecham p.l.c.
    Inventors: David Thomas Davies, Graham Elgin Jones, Andrew P Lightfoot, Roger Edward Markwell, Neil David Pearson
  • Calcilytic compounds
    Patent number: 7514473
    Abstract: Novel Calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: April 7, 2009
    Assignee: SmithKline Beecham, Corp.
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • Antibacterial agents
    Patent number: 7511035
    Abstract: Naphthyridine and quinoline derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: March 31, 2009
    Assignee: Glaxo Group Limited
    Inventors: William Henry Miller, Meagan B. Rouse, Mark Andrew Seefeld
  • Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
    Patent number: 7491714
    Abstract: Quinoline and naphthridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: February 17, 2009
    Assignee: Glaxo Group Limited
    Inventors: Jeffrey Michael Axten, Catherine Genevieve Yvette Dartois, Guy Marguerite Marie Gerard Nadler, Neil David Pearson
  • Aminopiperidine derivatives
    Patent number: 7312212
    Abstract: Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
    Type: Grant
    Filed: January 27, 2003
    Date of Patent: December 25, 2007
    Assignee: Glaxo Group Limited
    Inventors: Robert A Daines, William Henry Miller, Neil David Pearson, Israil Pendrak, Mark Andrew Seefeld
  • Antibacterial agents
    Patent number: 7232832
    Abstract: Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: June 19, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Jeffrey Michael Axten, William Henry Miller, Mark Andrew Seefeld
  • Quinolines and nitrogenated derivative thereof substituted in 4-position by a piperidine-containing moiety and their use as antibacterial agents
    Patent number: 7205408
    Abstract: Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: April 17, 2007
    Assignee: SmithKline Beecham, p.l.c.
    Inventors: David Thomas Davies, Graham Elgin Jones, Roger Edward Markwell, William Miller, Neil David Pearson
  • Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials
    Patent number: 7186730
    Abstract: Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: March 6, 2007
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Catherine Genevieve Yvette Dartois, Roger Edward Markwell, Guy Marguerite Marie Gerard Nadler, Neil David Pearson
  • Nitrogen-containing bicyclic heterocycles for use as antibacterials
    Patent number: 7141564
    Abstract: Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: November 28, 2006
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Gerald Brooks, David Thomas Davies, Graham Elgin Jones, Roger Edward Markwell, Neil David Pearson
  • Screening assay for inhibitors of human cytochrome P-450
    Patent number: 7056654
    Abstract: Fluorescein derivative as a substrate for cytochrome P450 enzymes.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: June 6, 2006
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Ramesh B Bambal, Jacqueline Carol Bloomer
  • 2-(pyrazol-3-yl)carbapenem derivatives
    Patent number: 7045619
    Abstract: A compound of formula (I): wherein R? is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; R? is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; or R? and R? together form an optionally substituted 5 or 6 membered heterocyclic ring with or without additional heteroatoms; R1 is (C1-6)alkyl which is unsubstituted or substituted by fluoro, a hydroxy group which is optionally protected by a removable hydroxy protecting group, or by an amino group which is optionally protected by a removable amino protecting group; R2 is hydrogen or methyl; and —CO2R3 is carboxy or a carboxylate anion or the group R3 is a removable carboxy protecting group. This invention also relates to processes for its preparation, intermediates and pharmaceutical compositions comprising compounds of formula (I).
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: May 16, 2006
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Eric Hunt, Steven Coulton, Jeremy David Hinks, Stephen Frederick Moss, Stephen Christopher Martin Fell, Alfred John Eglington, George Burton
  • Aminopiperidine derivatives as antibacterials
    Patent number: 7001913
    Abstract: Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: February 21, 2006
    Assignee: SmithKline Beecham P.L.C.
    Inventors: David Thomas Davies, Andrew Lightfoot, Roger Edward Markwell, Neil David Pearson