Patents Represented by Attorney, Agent or Law Firm Lori L. Kerber
  • Fluorescence-based high throughput screening assays for protein kinases and phosphatases
    Patent number: 6630311
    Abstract: The invention relates to novel fluorescence-based assays for protein kinases and phosphatases which can be used in high throughput screening. The methods of the invention utilize a competitive immunoassay to determine the amount of substrate that is phosphorylated or dephosphorylated during the course of a kinase or phosphatase reaction to yield a product, as well as the phosphorylating or dephosphorylating activity of a kinase or phosphatase.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: October 7, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Dennis E. Epps, Charles K. Marschke
  • TNF-related death ligand
    Patent number: 6440694
    Abstract: The invention relates to a novel tumor necrosis factor (TNF) homolog designated herein as TNF-related death ligand (TRDL). Isolated nucleic acid molecules are provided which encode TRDL. TRDL polypeptides are also provided, as are methods for identifying agonists and antagonists of TRDL activity.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: August 27, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael J. Bienkowski, Cynthia J. Mills, David A. Jones
  • Fluorescence-based high throughput sereening assays for protein kinases and phosphatases
    Patent number: 6203994
    Abstract: The invention relates to novel fluorescence-based assays for protein kinases and phosphatases which can be used in high throughput screening. The methods of the invention utilize a competitive immunoassay to determine the amount of substrate that is phosphorylated or dephosphorylated during the course of a kinase or phosphatase reaction to yield a product, as well as the phosphorylating or dephosphorylating activity of a kinase or phosphatase.
    Type: Grant
    Filed: December 2, 1998
    Date of Patent: March 20, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Dennis E. Epps, Charles K. Marschke