Patents Represented by Attorney Louis E. Davidson
  • Patent number: 5174471
    Abstract: A child-proof dispenser for pharmaceutical tablets capable of dispensing such tablets one at a time is disclosed. A sliding drawer with an open-topped tablet receptacle moves from a first position inside the dispenser where a tablet drops into the receptacle from a storage chamber to a second position outside of the dispenser. During this movement, a horizontal extension on the drawer prevents any further tablets from dropping out of the storage chamber. When the drawer is in the first position, detent means on such drawer mate in locking relation with detent means on a flexible arm of a locking member to prevent any movement of the drawer. Digital pressure on the flexible arm of the locking member will move the appropriate detent means out of locking relation to enable the drawer to move out and dispense the tablet.
    Type: Grant
    Filed: June 10, 1992
    Date of Patent: December 29, 1992
    Assignee: Miles Inc.
    Inventors: Edward Kozlowski, Lance Liljeqvist, Mathew Murray
  • Patent number: 4762792
    Abstract: A process is provided for isolating and purifying a cholesterol-rich fraction from mammalian blood plasma or serum. The resulting cholesterol-rich fraction is useful as a growth medium ingredient.
    Type: Grant
    Filed: October 28, 1986
    Date of Patent: August 9, 1988
    Assignee: Miles Inc.
    Inventors: Makram M. Girgis, David E. Jackson, Gerald L. Kruse, Frank J. Mannuzza, Joseph G. Montalto
  • Patent number: 4758517
    Abstract: A process is provided for increasing the yield of active cells of Treponema hyodysenteriae by growing such cells in a nutrient medium containing a cholesterol-rich bovine fraction. Killed cells grown in this manner can be used to produce a bacterin which is effective against swine dysentery.
    Type: Grant
    Filed: October 28, 1986
    Date of Patent: July 19, 1988
    Assignee: Mobay Corporation
    Inventor: Richard E. Parizek
  • Patent number: 4728613
    Abstract: Extracellular enzymes can be recovered from a whole fermentation beer by adding to the whole beer a mixture of a polymer and an inorganic salt. This total mixture produces an enzyme-rich polymer phase and a cell debris-containing, enzyme-poor salt phase which can be separated to produce an enzyme-rich product from the polymer phase.
    Type: Grant
    Filed: August 5, 1986
    Date of Patent: March 1, 1988
    Assignee: Miles Laboratories, Inc.
    Inventors: Jack W. Brewer, Charles E. Brothers, Terry F. Farver, Chong Y. Kim, Eunkyu Lee
  • Patent number: 4724203
    Abstract: A new compound, carboylamidobiotinylated horseradish peroxidase, is produced. It has utility in immunohistochemical measurement procedures.
    Type: Grant
    Filed: October 4, 1985
    Date of Patent: February 9, 1988
    Assignee: Miles Laboratories, Inc.
    Inventor: Harmesh K. Sharma
  • Patent number: 4570630
    Abstract: An inhalation device for dispensing medicament has a horizontally rotatable medicament delivery member positioned between a medicament storage chamber and an air inhalation chamber where the medicament is suspended in air for subsequent inhalation by a patient.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: February 18, 1986
    Assignee: Miles Laboratories, Inc.
    Inventors: Roderick D. Elliott, Phillip J. Gardiner
  • Patent number: 4542103
    Abstract: A method for determining the amount of IgG present in a neonatal foal or calf or in the colostrum of a dam or cow. The method involves contacting a body fluid sample with biologically inert latex particles, measuring the amount of agglutination which occurs, and determining the amount of IgG present. The latex particles are diluted to a final concentration of from about 0.25 to 2.0 percent (w/v) at a pH of from about 7.5 to 9.0 with a buffer. The body fluid is diluted to a range of from 0.01:5 parts to 0.01:2160 parts, v/v basis, at a pH of from about 7.5 to 9.0.
    Type: Grant
    Filed: November 16, 1983
    Date of Patent: September 17, 1985
    Assignee: Miles Laboratories Inc.
    Inventor: Ernest C. Adams
  • Patent number: 4376118
    Abstract: Nonaqueous solution of a tetracycline antibiotic salt which is stable upon extended storage comprises a mixture of a tetracycline antibiotic salt, nonaqueous diluent, nonaqueous solvent, and nonaqueous nonionic solubilizer. It preferably also contains an antioxidant and a nonaqueous anionic solubilizer.
    Type: Grant
    Filed: May 19, 1981
    Date of Patent: March 8, 1983
    Assignee: Miles Laboratories, Inc.
    Inventors: Lawrence J. Daher, George C. Hoss, Victor A. Raul
  • Patent number: 4348480
    Abstract: A novel glucose isomerase enzyme useful for the conversion of glucose to fructose can be prepared by growing under aerobic conditions a culture of Bacillus licheniformis ATCC 31604 in a medium containing appropriate nutrients and then recovering the enyzme therefrom.
    Type: Grant
    Filed: June 4, 1980
    Date of Patent: September 7, 1982
    Assignee: Miles Laboratories, Inc.
    Inventor: Charles E. Brownewell
  • Patent number: 4348482
    Abstract: A process is provided for decreasing the thermal stability of Mucor microbial rennet without substantially reducing its milk-clotting activity by contacting an aqueous solution thereof with a methionine-oxidizing means under conditions effective substantially to decrease the thermal stability of the microbial rennet. The resultant treated microbial rennet is dramatically less heat stable than untreated microbial rennet and can serve as replacement for calf rennet in traditional cheese-making processes. The preferred methionine-oxidizing means is hydrogen peroxide or dye-sensitized photooxidation.
    Type: Grant
    Filed: September 10, 1979
    Date of Patent: September 7, 1982
    Assignee: Miles Laboratories, Inc.
    Inventor: Dennis A. Cornelius
  • Patent number: 4347222
    Abstract: Apparatus for generating anaerobic atmosphere is described wherein a liquid and a composition which can react with such liquid to produce a reducing gas are placed in adjacent receptacles each sealed by a rupturable film. A rupturing means can then be inserted through the rupturable films to enable the liquid and composition to come into reactive contact and generate the desired gases. A catalyst is located in an adjacent receptacle which communicates with the surrounding atmosphere to catalyze the reaction between the reducing gas and oxygen to thus remove oxygen from the surrounding atmosphere.
    Type: Grant
    Filed: April 21, 1981
    Date of Patent: August 31, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: Glenn L. Beall, Robert P. Noonan
  • Patent number: 4346515
    Abstract: Apparatus and process are described for telescopically mating top and bottom molded petri dish members wherein the top and bottom members positioned in spaced, substantially coaxial face-to-face relation are moved along a predetermined path, and during travel along such path are moved toward each other into telescopic assembled relation.
    Type: Grant
    Filed: April 11, 1980
    Date of Patent: August 31, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: William F. Lodding, John T. Murray
  • Patent number: 4334095
    Abstract: Organic acids, such as citric acid, malic acid and lactic acid, can be extracted from aqueous solutions thereof by contacting such solutions with a mixture of a water immiscible amine and a water immiscible organic acid dissolved in a suitable water immiscible solvent.
    Type: Grant
    Filed: October 6, 1980
    Date of Patent: June 8, 1982
    Assignee: Miles Laboratories, Inc.
    Inventor: Avraham M. Baniel
  • Patent number: 4294930
    Abstract: A process is provided for improving the recovery of microbial cell biomass, which includes the steps of subjecting a culture broth containing chain-forming microorganisms to shearing conditions sufficient to shorten the chain-length of microbial cells whereby the packed cell volume of the cell biomass is substantially reduced and then recovering the thus treated biomass from the broth by centrifugation.
    Type: Grant
    Filed: August 22, 1979
    Date of Patent: October 13, 1981
    Assignee: Miles Laboratories, Inc.
    Inventors: Jeffrey T. Barach, Leslie Bluhm
  • Patent number: 4285975
    Abstract: Brewer's wort is prepared by a process comprising the steps of forming at 82.degree. to 88.degree. C. an aqueous mash containing malted cereal, unmalted cereal and an effective amount of a starch liquefying thermostable alpha amylase; maintaining the mash at such temperature until a substantial amount of the cereal starch has been liquefied; cooling the mash to a temperature of 60 to 65.degree. C.; adding an effective amount of starch saccharifying diastatic enzyme to the mash; maintaining the resulting mixture at 60 to 65.degree. C. until a substantial amount of the cereal starch has been saccharified; then raising the temperature of the mash to at least 72.degree. C. and maintaining the mash at this temperature until the starch has been completely converted.
    Type: Grant
    Filed: January 29, 1980
    Date of Patent: August 25, 1981
    Assignee: Miles Laboratories, Inc.
    Inventor: Paul R. Glenister
  • Patent number: 4255455
    Abstract: Casein with lowered cholesterol content is produced by dispersing within an aqueous medium containing casein and cholesterol an effective casein-cholesterol bond-reducing emulsifying agent, such as a polyglycerol fatty acid ester, and thereafter isolating the casein from the aqueous medium.
    Type: Grant
    Filed: March 12, 1979
    Date of Patent: March 10, 1981
    Assignee: Miles Laboratories, Inc.
    Inventors: Alta J. Hefley, Henry P. Furgal
  • Patent number: 4251632
    Abstract: A shaped bacterial cell aggregate having increased hardness is produced by adding previously-produced dried finely-divided bacterial cell aggregate to bacterial cell aggregate subsequent to its formation but prior to its shaping.
    Type: Grant
    Filed: September 11, 1978
    Date of Patent: February 17, 1981
    Assignee: Miles Laboratories, Inc.
    Inventors: Anthony H. Chen, Yun-Chi Jao
  • Patent number: 4251332
    Abstract: Naphthalene can be reduced to isotetralin by electrolysis of a solution of naphthalene, an electrolyte and an alcohol in a solvent of either ethylenediamine or liquid ammonia.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: February 17, 1981
    Assignee: Miles Laboratories, Inc.
    Inventors: David Ginsburg, Wilfried J. W. Mayer
  • Patent number: D268096
    Type: Grant
    Filed: December 12, 1980
    Date of Patent: March 1, 1983
    Assignee: Miles Laboratories, Inc.
    Inventors: John J. Austin, Jr., Robert L. Dickens, Albert Yochim
  • Patent number: D280291
    Type: Grant
    Filed: January 13, 1983
    Date of Patent: August 27, 1985
    Assignee: Miles Laboratories, Inc.
    Inventors: Joan C. Copsey, John J. McNamara, Jr., Jeremy L. Parker