Patents Represented by Attorney, Agent or Law Firm Luann Cserr
  • Production of procoagulant proteins
    Patent number: 5004803
    Abstract: Hybrid procoagulant proteins are disclosed which contain peptide sequences of human blood coagulation factors V and VIII. DNA molecules encoding these proteins and materials and methods for expressing them are also disclosed. Preferably, peptide sequence in the B domain of Factor VIII is replaced with peptide sequence derived from human Factor V.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: April 2, 1991
    Assignee: Genetics Institute, Inc.
    Inventors: Randal J. Kaufman, Debra Pittman
  • Truncated thrombolytic proteins
    Patent number: 5002887
    Abstract: Thrombolytic proteins are disclosed which have tissue plasminogen-type activity. The proteins are characterized by the presence of 0, 1, 2 or 3 N-linked polysaccharide substituents covalently bonded thereto and by a polypeptide sequence of the formula(a)A-R.sup.1 -B-R.sup.2 -C-R.sup.3 Dwherein A, B, C, and D are the following polypeptide sequences substantially as shown in FIG. 1:A is Gly-.sub.3 or Ser.sub.1 through Trp.sub.116, encompassing domain a;B is Ala.sub.120 through Gly.sub.183 ;C is Ala.sub.187 through Leu.sub.447 ;D is Val.sub.451 through Pro.sub.527 ; anda is a peptide domain comprising a sequence of 0-93 amino acids selected from the sequence Gly.sub.-3 or Ser.sub.1 through Thr.sub.91 ; R.sup.1, R.sup.2 and R.sup.3 are each a tripeptide sequence linking said A, B, C and D by peptide bonds, up to three of R.sup.1, R.sup.2 and R.sup.3 being a tripeptide sequence other than Asn-X-Thr or Asn-X-Ser, wherein X is any amino acid.
    Type: Grant
    Filed: July 3, 1986
    Date of Patent: March 26, 1991
    Assignee: Genetics Institute, Inc.
    Inventor: Glenn R. Larsen
  • Pharmaceutical formulations of plasminogen activator proteins
    Patent number: 4980165
    Abstract: Pharmaceutical formulations for intravenous bolus injection are presented that provide thrombolytic proteins, especially "second generation" tPA molecules, in relatively high concentrations at low concentrations of excipients.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: December 25, 1990
    Assignee: Genetics Institute, Inc.
    Inventors: Benjamin S. Isaacs, Himakshi Patel
  • Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
    Patent number: 4959455
    Abstract: A novel family of primate IL-3 polypeptides is provided via recombinant techniques.
    Type: Grant
    Filed: March 4, 1987
    Date of Patent: September 25, 1990
    Assignee: Genetics Institute, Inc.
    Inventors: Steven C. Clark, Agnes B. Ciarletta, Yu-Chung Yang
  • Treatment of AIDS-type disease
    Patent number: 4921837
    Abstract: Disclosed herein is the treatment of patients suffering from AIDS-type disease with a colony stimulating factor alone or together with erythropoietin, and/or an anti-viral agent and/or IL-2.
    Type: Grant
    Filed: July 24, 1987
    Date of Patent: May 1, 1990
    Assignee: Genetics Institute Inc.
    Inventor: Robert E. Donahue