Patents Represented by Law Firm Luedeka, Hodges & Neeley
  • Hybrid nitrosoureidoanthracyclines having antitumor activity
    Patent number: 4973675
    Abstract: N-2-chloroalkyl nitrosouredio derivatives of anthracycline-based compounds having antitumor activity are disclosed. Relative to the clinically-used drugs adriamycin and daunorubicin, substantially enhanced antitumor activity against parent murine P388 leukemia and an adriamycin-resistant P388 leukemia subline has been found for the N-2-chloroethylnitrosoureido derivatives of adriamycin, daunorubicin and epirubicin. Chemical stability has been found to be enhanced when employing the 4'-epi stereoisomeric family of these compounds.
    Type: Grant
    Filed: April 13, 1989
    Date of Patent: November 27, 1990
    Assignee: University of Tennessee Research Center
    Inventors: Mervyn Israel, Ramakrishnan Seshadri