Abstract: A method of determining the length of a polynucleotide target is provided. With this method, a target is first hybridized to an array of first probes having different, determined lengths, resulting in the formation of duplexes between the polynucleotide target and the first probes. These duplexes have a single stranded section of target if the target is longer than the first probe it is in a duplex with. Next, a second probe having a determined length is hybridized to these duplexes. If the length of the target is greater than the length of the first probe it is displaced during this hybridization step by the process of branch migration. In contrast, if the length of the target is less than or equal to the length of the first probe, it is not displaced. Thus, the length of the polynucleotide target can be determined.

Abstract: In a fuel cell assembly with at least one cell including an electrolyte layer, a pair of gas diffusion electrode layers interposing said electrolyte layer between them, and a pair of flow distribution plates (5) for defining passages (10, 11) for fuel and oxidizer gases that contact said gas diffusion electrode layers, a heater 62 and various sensors (61a, 61b and 61c) are formed on at least one of the flow distribution plates so that the work needed for installing the heater and sensors is simplified. By embedding them in a substrate, the need for a complex sealing arrangement can be eliminated. In particular, if each flow distribution plate is formed by performing an etching process on a substrate, and forming the heater and sensors in succession to the step of forming each flow distribution plate, the installation of sensors and fabrication of the fuel call are simplified.

Abstract: An automatic method for the registration of prone and supine computed tomographic colonography data is provided. The method improves the radiologist's overall interpretation efficiency as well as provides a basis for combining supine/prone computer-aided detection results automatically. The method includes determining (centralized) paths or axes of the colon from which relatively stationary points of the colon are matched for both supine and prone positions. Stretching and/or shrinking of either the supine or prone path perform registration of these points. The matching and registration occurs in an iterative and recursive manner and is considered finished based on one or more decision criteria.

Abstract: An illuminator is disposed in an air path of a ventilation blower disposed above the ceiling of an elevator cage. An illumination shielding device is disposed below the illuminator and also in the air path. The illumination shielding device includes a plurality of spaced apart parallel rectangular plates, where the lower portions of the plates are inclined toward the elevator cage sidewalls. One or more such combinations of illuminator and illumination shielding device can be used in an elevator cage. Preferably, illuminators and illumination shielding devices are disposed at corners of the elevator cage ceiling, in order to maximize elevator cage capacity. A reflective plate can be mounted to the elevator cage ceiling.

Abstract: Optical characterization of lateral features of a pattern is provided. A plane-wave optical response is calculated for each feature. At least one of these plane-wave responses is calculated from an effective optical property (e.g., a waveguide modal refractive index). Such effective optical properties depend on feature geometry and on intrinsic material optical properties. The plane-wave responses for each feature are combined to generate a modeled pattern response. By fitting the modeled pattern response to a corresponding measured pattern response, estimates for pattern feature parameters are obtained. The use of an effective optical property improves model accuracy, especially for features having a size on the order of a wavelength or less, without significantly increasing computation time.

Abstract: Torque control capability is provided to a position controlled robot by calculating joint position inputs from transformation of the desired joint torques. This is based on calculating the transfer function 1/E(s), which relates the desired joint torque to joint position. Here E(s) is a servo transfer function D(s) or an effective servo transfer function D*(s). The use of an effective servo transfer function D*s) is helpful in cases where joint nonlinearities are significant. The effective servo transfer function D*(s) is defined with respect to an ideal joint transfer function G*(s)=1/(Ieffs2+beffs), where Ieff is an effective moment of inertia and beff is an effective damping coefficient.

Abstract: A finite impulse response filter having tap weight rotation is provided, where each tap has a corresponding coefficient selector. Each coefficient selector includes N coefficients, where N is the number of taps. Each coefficient selector provides one of its corresponding coefficients as an input to a multiplier. Each multiplier also receives an input from a triggered track and hold tap. The tap coefficients are selected according to the time delay since the corresponding track and hold tap was most recently triggered. In this manner, the tendency of multiplier gain nonuniformity to degrade filter operation in the presence of tap weight rotation is reduced. In another embodiment, an offset selector is provided, to reduce the tendency of component offsets to degrade filter operation in the presence of tap weight rotation.

Abstract: A standard cell library having a globally scalable transistor channel length is provided. In this library, the channel length of every transistor within a cell can be globally scaled, within a predetermined range, without changing cell functionality, cell size, or cell terminal positions. Such a cell library advantageously addresses the intra-generational redesign problem, since cell channel lengths in library cells can be decreased as fabrication technology evolves, without requiring intra-generational redesign of existing circuit layouts. Preferably, this change in channel length is obtained by altering a single mask layer of the library design (e.g., the mask for the poly-silicon layer).

Abstract: A phasor can be employed within the resonator of an optical parametric oscillator (OPO) to adjust the absolute and relative phase of OPO beams. An embodiment of the invention comprises an OPO having at least one phasor for receiving and adjusting the phase of one or more beams resonating within the optical cavity which forms part of the OPO. Smooth alteration of the phases of the OPO beams using the at least one phasor facilitates continuous tuning of the wavelength of at least one of the beams. In another embodiment, the at least one phasor may be a translatable wedge or have adjustable refractive index to alter the phases of the OPO beams. In an additional embodiment, each at least one phasor may be comprised of more than one material, held fixedly together.

Abstract: A method to define a curved slab region of interest that includes vessels while maximally excluding surrounding soft tissue and bone is provided. The thickness of the curved slab is automatically adapted to the thickness of the vessel and follows the tortuous vessel(s) so that an increase in tortuousity does not result in a disproportionate increase in the region of interest required to enclose the vessel. A plurality of boundary pairs is determined in the view plane to define a vessel. Vessel-intensities are determined for each one of the boundary pairs. The boundary pairs with associated intensities define the view of the vessel in the projection plane. Context-intensity could be defined in the area surrounding the boundary pairs in the projection and/or transverse plane. The method also includes several steps that will result in a better boundary outline and view of the vessel.

Abstract: A cryogenic gas is liquefied using a refrigeration system [101] thermally coupled at an evaporator [125] to a cold end of a gas supply system [103] within a dewar [116]. The refrigerator has a minimum temperature at an evaporator [125] above the boiling point of the gas at atmospheric pressure but below the boiling point of the gas at a high pressure. Thus, the gas is compressed [128] to high pressure so it condenses when cooled by the evaporator [125]. As it expands at a flow restrictor [148], a portion evaporates and cools a fraction to the temperature of the boiling point of the gas at atmospheric pressure, producing liquefied gas. Opening a purge valve [142] sends warm gas upward through heat exchange section [146] and out through a three-way valve [138] for defrosting. To reduce clogging, the gas supply valve [138] is controlled by a gas purity sensor [158].

Abstract: A rigid column and a suspension knee are combined in a probe held in assembly via its column. The suspension knee has a base arm laterally connecting at and propagating away from the column. The base arm extends up to a lateral knee extension where a reverse arm continues from the base arm back in direction towards a central axis of the column. The reverse arm terminates in a contact tip in a tip offset to the column axis that is smaller than the lateral knee extension. During application of a contacting force onto the contact tip, a first deflection of the base arm and a second deflection of the reverse arm counter act in conjunction with base and reverse arms' structural configurations. As a result, scrub motion may be well defined in direction and magnitude without need for additional guidance of the deflecting probe structure.

Abstract: Devices and methods are provided for administering a fluid to a neuronal site. The device comprises a reservoir, an aperture in fluid connection to the reservoir, and electrical means for moving to the fluid to or through the aperture. The electrical means may take the form of electroosmotic force, piezoelectric movement of a diaphragm or electrolysis of a solution. The electrical means may be external to the host, implanted in the host or may be photodiodes activated by light, particularly where the neuronal site is associated with the retina.

Abstract: A Micro-Electro-Mechanical System (MEMS) and double-layer nozzle based high efficiency, lightweight, low cost, compact, portable fiber-optic connector cleaning apparatus useful for various fiber optic communications applications such as fiber optic cable plant maintenance. The double-layer nozzle design enables the delivery of compressed, filtered air and solvent to connector surfaces. A built-in MEMS pump sucks the air and solvent back to remove particles and contaminations without leaving residues and without scratching the connector surfaces. An interchangeable external needle allows the cleaner to quickly adapt to all kinds of fiber optic connectors. No disassembly is required. The connector cleaner is therefore both fast and effective at cleaning various male and female fiber optic connectors. The fiber optic connector cleaner with 3–5 cc solvent weighs less than half a pound and can be held and operated by one hand.

Abstract: Multiple hygienic effects are concurrently applied to structures of body cavities. This is established by two or more light sources each capable of delivering a light beam to the structures using optical pathways whereby each light beam provides a unique hygienic effect to the structures. The device could be a handheld device with detachable components. The device could include a massaging mechanism and/or a vibrating mechanism. An agent could be used to the body cavity to assist in the hygienic treatment plan. A cradle could be included to store the device, reload the power supply of the device, as well as a means to communicate with a hygienic service provider. The cradle could also host a display and a selector. A test mechanism could be included to test a performance of the device or to calibrate components of the device.

Abstract: The present invention provides a method and apparatus of compiling and providing business data in a distributed computer system, preferably the Internet or any other type of computer linked network system. The present invention also provides a computer program product that contains business data compiled from files containing business data located in a distributed computer system. The present invention to provide a cost-effective method for automatically compiling a business data as well as an automated method for refreshing business data so as to keep it current. The advantage of the present invention is that it enables one to compile business data from files in a distributed computer system in a cost effective and time effective manner taking advantage of the large number of data that is available in a distributed computer system. Another advantage is that the present invention enables one to quickly update business data to stay current.

Abstract: The present invention provides a powerful and robust classification and prediction tool, methodology, and architecture for supervised learning, particularly applicable to complex datasets where multiple factors determine an outcome and yet many other factors are irrelevant to prediction. Among those features which are relevant to the outcome, they have complicated and influential interactions, though insignificant individual contributions. For example, polygenic diseases may be associated with genetic and environmental risk factors. This new approach allow us consider all risk factors simultaneously, including interactions and combined effects. Our approach has the strength of both binary classification trees and regression. A simple rooted binary tree model is created with each split defined by a linear combination of selected variables. The linear combination is achieved by regression with optimal scoring. The variables are selected using backward shaving.

Abstract: The present invention provides a new way of optimizing integrated circuit (IC) designs in the physical design stage after detail routing. A key element is a novel hybrid layout representation referred to as the geotopological layout in which some nets are represented by their determined geometrical wiring paths and some by their respective wiring topology at the same time. In the IC design flow, a routed layout with geometrical wiring paths is transformed into a geotopological layout. All layout modifications are then performed according to the geotopological layout. An embedded design rule checker ensures the validity thereof. Finally, a new geometrical layout is regenerated accordingly, including all the layout changes for the targeted optimization. This geotopological approach advantageously enables an IC designer to modify a routed layout for various optimization targets, while advantageously maintaining the exact routing paths of critical nets that are not modifiable.

Abstract: Quasi-phasematching design to provide an approximation to a desired spectral amplitude response A(f) is provided. An initial phase response ?(f) corresponding to A(f) is generated. Preferably, d2?(f)/df2 is proportional to A2(f). A function h(x) is computed such that h(x) and H(f)=A(f)exp(i?(f)) are a Fourier transform pair. A domain pattern function d(x) is computed by binarizing h(x) (i.e., approximating h(x) with a constant-amplitude approximation). In some cases, the response provided by this d(x) is sufficiently close to A(f) that no further design work is necessary. In other cases, the design can be iteratively improved by modifying ?(f) responsive to a difference between the desired response A(f) and the response provided by domain pattern d(x). Various approaches for binarization are provided. The availability of multiple binarization approaches is helpful for making design trades (e.g., in one example, fidelity to A(f) can be decreased to increase efficiency and to increase domain size).

Abstract: A micromanipulator comprising a tubular structure and a structural compliance mechanism that are formed from a tube made of an elastic and/or superelastic material. Fabricated with laser machining and has no mechanical joints, the micromanipulator can be manipulated in various motions and degree-of-freedoms without permanent deformation. Shape Memory Alloys (SMAs) in one embodiment are implemented as main actuators of the micromanipulator. The micromanipulator can be implemented with multiple SMAs to manipulate the mechanism with multiple degree-of-freedom. In another implementation, multiple segments of the mechanisms are formed and arranged in various configurations, including a “double-helix”-like configuration, for enabling intricate motions of the micromanipulator. The micromanipulator is useful for intravascular interventional applications and particularly ultrasonic imaging when coupled with an ultrasound transducer.