Patents Represented by Attorney, Agent or Law Firm Lydia McNally
  • Method for treating cells resistant to antineoplastic agents
    Patent number: 6774143
    Abstract: The present invention relates to methods for treating multidrug resistant cells, preferably multidrug resistant cancer cells with discodermolide. Discodermolide is found to be effective in limiting the growth of otherwise growth unregulated cells having tubulin mutations and in promoting phosphorylation of the oncogene RAF-1.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: August 10, 2004
    Assignee: Novartis AG
    Inventors: Peter Lassota, Christopher Turchik Jagoe
  • Spherical particles containing microorganism cells having enzyme activity
    Patent number: 6465227
    Abstract: A process is presented for producing spherical particles containing microorganism cells having desired enzyme activity. The process comprises the steps of mixing the cells directly with a primary or secondary amine-containing polymer, combining the resulting mixture with an organic solvent to form a two-phase system, and then adding a bifunctional cross-linking agent to yield the spherical particles. The preferred enzyme activities are D-amino acid oxidase and glutarylacylase activities.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: October 15, 2002
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Arno Reichert, Waander Riethorst, Franz Knauseder, Norbert Palma