Patents Represented by Attorney Lyle W. Spruce

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  • Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof
    Patent number: 7241792
    Abstract: The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: July 10, 2007
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: P. Douglas Boatman, Thomas O. Schrader, Graeme Semple, Philip J. Skinner, Jae-Kyu Jung
  • Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
    Patent number: 7132426
    Abstract: The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.
    Type: Grant
    Filed: July 13, 2004
    Date of Patent: November 7, 2006
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Robert M. Jones, Graeme Semple, Yifeng Xiong, Young-Jun Shin, Albert S. Ren, Imelda Calderon, Beatriz Fioravanti, Jin Sun Karoline Choi, Carleton R. Sage
  • 5HT2C receptor modulators
    Patent number: 6953787
    Abstract: The present invention relates to novel compounds of Formula (I): which act as 5HT2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: October 11, 2005
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Brian Smith, Jeffrey Smith