Patents Represented by Attorney, Agent or Law Firm Lynn E. Murry
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Patent number: 6476212Abstract: The present invention provides purified, corn ear-derived polynucleotides (cdps) which encode corn ear-derived polypeptides (CDPs). The invention also provides for the use of cdps or their complements, oligonucleotides, or fragments in methods for determining altered gene expression, to recover regulatory elements, and to follow inheritance of desirable characteristics through hybrid breeding programs. The invention further provides for vectors and host cells containing cdps for the expression of CDPs. The invention additionally provides for (i) use of isolated and purified CDPs to induce antibodies and to screen libraries of compounds and (ii) use of anti-CDP antibodies in diagnostic assays.Type: GrantFiled: May 14, 1999Date of Patent: November 5, 2002Assignee: Incyte Genomics, Inc.Inventors: Raghunath V. Lalgudi, Laura Y. Ito, Bradley K. Sherman
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Patent number: 6458575Abstract: The invention provides a human cyclophilin-type peptidyl-prolyl cis/trans isomerase (CPCI) and polynucleotides which identify and encode CPCI. The invention also provides expression vectors, host cells, antibodies, agonists, and antagnists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of CPCI.Type: GrantFiled: November 15, 1999Date of Patent: October 1, 2002Assignee: Incyte Genomics, Inc.Inventors: Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Chandra Patterson
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Patent number: 6458561Abstract: The invention provides a nucleic acid molecule which encodes the human NIM1 kinase. It also provides for the use of the nucleic acid molecule, fragments, variants and complements thereof and of the protein, portions thereof and antibodies thereto for characterization, diagnosis, evaluation, treatment, or prevention of disorders associated with expression. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic organism or model system.Type: GrantFiled: March 13, 2000Date of Patent: October 1, 2002Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Angela Molteni, Paola Magnaghi, Roberta Bosotti, Emanuela Scacheri, Antonella Isacchi, David M. Hodgson
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Patent number: 6426186Abstract: The invention provides polynucleotides and polypeptides that are co-expressed with genes known to be involved in bone remodeling and osteoporosis. The invention also provides expression vectors, host cells, and methods for making a polypeptide, for screening or purifying ligands, and for diagnosing disorders associated with bone remodeling or osteoporosis.Type: GrantFiled: January 18, 2000Date of Patent: July 30, 2002Assignee: Incyte Genomics, IncInventors: Karen A. Jones, Wayne Volkmuth, Michael G. Walker
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Patent number: 6416991Abstract: The invention provides human cyclic nucleotide phosphodiesterases (HSPDE10A) and polynucleotides which identify and encode HSPDE10A. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists and methods for diagnosing or treating disorders associated with expression of HSPDE10A.Type: GrantFiled: June 14, 2000Date of Patent: July 9, 2002Assignee: Incyte Genomics, Inc.Inventors: Stephen C. Phillips, Jerry Lanfear, Lindsay Fawcett, Olga Bandman, Ian Harrow
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Patent number: 6379904Abstract: The invention provides a human PINCH protein homolog (PINCH-PH) and polynucleotides which identify and encode PINCH-PH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PINCH-PH.Type: GrantFiled: March 20, 2000Date of Patent: April 30, 2002Assignee: Incyte Genomics, Inc.Inventors: Preeti Lal, Karl J. Guegler, Neil C. Corley
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Patent number: 6350581Abstract: The present invention provides a human tumor-associated antigen (TUAN) and polynucleotides which identify and encode TUAN. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing TUAN and for treating or preventing disorders associated with expression of TUAN.Type: GrantFiled: January 8, 1999Date of Patent: February 26, 2002Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Surya K. Goli, Purvi Shah, Neil C. Corley
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Patent number: 6350448Abstract: The present invention provides a human prostate-associated protease (HUPAP) and polynucleotides which identify and encode HUPAP. The invention also provides expression vectors, host cells, antibodies, antagonists, and antisense molecules. The invention also provides methods for treating disorders associated with expression of HUPAP.Type: GrantFiled: January 7, 2000Date of Patent: February 26, 2002Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Preeti Lal
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Patent number: 6322977Abstract: The invention provides a mammalian nucleic acid sequence and fragments thereof. It also provides for the use of the nucleic acid sequence for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with gene expression and for the production of a model system. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid sequence.Type: GrantFiled: April 14, 1999Date of Patent: November 27, 2001Assignee: Incyte Genomics, Inc.Inventors: Preeti Lal, Matthew R. Kaser, Mariah R. Baughn
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Patent number: 6287786Abstract: The invention provides a mammalian nucleic acid molecule and fragments thereof. It also provides for the use of the nucleic acid molecule for the characterization, diagnosis, or treatment of conditions, diseases and disorders associated with gene expression and for the production of a model system. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid molecule.Type: GrantFiled: July 31, 2000Date of Patent: September 11, 2001Assignee: Incyte Genomics, Inc.Inventors: Matthew R. Kaser, Jennifer L. Hillman, Mariah R. Baughn
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Patent number: 6277377Abstract: The invention provides a new human phosphodiesterase regulatory subunit (HPRS) and polynucleotides which encode HPRS. The invention also provides expression vectors, host cells, agonists, the complement of the polynucleotide sequence and antibodies. The invention also provides methods for treating disorders associated with expression of HPRS.Type: GrantFiled: February 22, 1999Date of Patent: August 21, 2001Assignee: Incyte Genomics, Inc.Inventors: Jennifer L. Hillman, Neil C. Corley, Purvi Shah
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Patent number: 6277574Abstract: The invention provides novel kidney disease-associated genes and polypeptides encoded by those genes. The invention also provides expression vectors, host cells, and antibodies. The invention also provides methods for diagnosing, treating or preventing diseases of the kidney.Type: GrantFiled: April 9, 1999Date of Patent: August 21, 2001Assignee: Incyte Genomics, Inc.Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler, Yalda Azimzai, Henry Yue
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Patent number: 6245526Abstract: The invention provides a mammalian nucleic acid sequence and fragments thereof. It also provides for the use of these nucleic acid sequences in a model system for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with expression of the mammalian nucleic acid sequence. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid sequence.Type: GrantFiled: May 26, 1999Date of Patent: June 12, 2001Assignee: Incyte Pharmaceuticals, Inc.Inventors: Henry Yue, Matthew R. Kaser, Mariah R. Baughn
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Patent number: 6238666Abstract: The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a human rantes homolog (PTEC). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.Type: GrantFiled: September 14, 1999Date of Patent: May 29, 2001Assignee: Incyte Genomics, Inc.Inventors: Phillip R. Hawkins, Olga Bandman, Lynn E. Murry
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Patent number: 6235880Abstract: The present invention provides a human sulfonylurea receptor (SURH) and the polynucleotides which identify and encode SURH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding SURH and methods for producing the protein. The invention also provides pharmaceutical compositions containing SURH, agonists to SURH, or antagonists to SURH, and in the use of such compositions for the prevention or treatment of diseases associated with the expression of SURH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding SURH for the treatment of diseases associated with the expression of SURH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding SURH, or anti-SURH antibodies which specifically bind to SURH.Type: GrantFiled: December 9, 1998Date of Patent: May 22, 2001Assignee: Incyte Pharmaceuticals, Inc.Inventors: Janice Au-Young, Olga Bandman, Roger Coleman
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Patent number: 6232454Abstract: The invention provides human proteinase molecules (HPRM) and polynucleotides which identify and encode HPRM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HPRM.Type: GrantFiled: February 27, 1998Date of Patent: May 15, 2001Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn
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Patent number: 6221843Abstract: The invention provides human keratins (KERT) and polynucleotides which identify and encode KERT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of KERT.Type: GrantFiled: July 23, 1999Date of Patent: April 24, 2001Assignee: Incyte Genomics, Inc.Inventors: Y. Tom Tang, Jennifer L. Hillman, Neil C. Corley, Mariah Baughn
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Patent number: 6183968Abstract: The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes for the composition.Type: GrantFiled: March 25, 1999Date of Patent: February 6, 2001Assignee: Incyte Pharmaceuticals, Inc.Inventors: Olga Bandman, Preeti Lal, Jennifer L. Hillman, Henry Yue, Roopa Reddy, Karl J. Guegler, Mariah R. Baughn
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Patent number: 6168933Abstract: The invention provides a mammalian nucleic acid molecule and fragments thereof. It also provides for the use of the nucleic acid molecule for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with gene expression and for the production of a model system. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid molecule.Type: GrantFiled: June 8, 1999Date of Patent: January 2, 2001Assignee: Incyte Pharmaceuticals, Inc.Inventors: Matthew R. Kaser, Jennifer L. Hillman, Mariah R. Baughn