Patents Represented by Attorney Lynne Christenbury

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  • Method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function
    Patent number: 5278045
    Abstract: This invention is directed to a composition comprising a substantially purified protein which enhances endogenous stimulus-induced neurotransmitter release, said neurotransmitter being selected from the group consisting of acetylcholine, dopamine or serotonin, said protein having a binding affinity constant of at least 2.9.+-.0.8 nM for tritiated 3,3-bis(4-pyridinylmethyl)-1-phenylindolin-2-one as determined by a Scatchard analysis, and said protein being trypsin sensitive and phospholipase C insensitive.
    Type: Grant
    Filed: February 28, 1990
    Date of Patent: January 11, 1994
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventor: Sang W. Tam
  • Method of treating neurological dysfunction using neutrotransmitter enhancers
    Patent number: 5171745
    Abstract: This disclosure relates to a method of treating a neurological dysfunction in a mammal using a combination of at least one neurotransmitter enhancer and at least one serotonin receptor antagonist.
    Type: Grant
    Filed: July 13, 1990
    Date of Patent: December 15, 1992
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Kimi F. De Noble, Victor J. De Noble, Richard A. Earl, Melvyn J. Myers, Victor J. Nickolson