Patents Represented by Attorney M. C. Bogosian
  • Patent number: 5801151
    Abstract: The present invention is a method for rendering cotton fiber cells that are post-anthesis and pre-harvest available for analysis of their physical properties. The method includes the steps of hydrolyzing cotton fiber cells and separating cotton fiber cells from cotton ovules thereby rendering the cells available for analysis. The analysis of the fiber cells is through any suitable means, e.g., visual inspection. Visual inspection of the cells can be accomplished by placing the cells under an instrument for detection, such as microscope or other means.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: September 1, 1998
    Assignee: Associated Universities, Inc.
    Inventor: Jack Van't Hof
  • Patent number: 5690903
    Abstract: Methods for the preparation and use of a biological delivery system are disclosed. The method of preparation includes the loading of a non-biological material into a biostructure having a load-bearing structure. The method also includes the removal of some of the biostructure's contents and the loading of a non-biological material into the biostructure. The biostructure is biologically compatible with the host, and preferably is derived from the host, the host's species or a related species. The loaded biostructure is used directly, or it can be targeted to specific cells, tissues and/or organs within a host. The targeted biostructure can be used to deliver the non-biological material to a specified tissue, organ or cell within a host for diagnostic, therapeutic or other purposes.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: November 25, 1997
    Inventor: James F. Hainfeld
  • Patent number: 5678234
    Abstract: The present invention provides a method for encapsulating and stabilizing radioactive, hazardous and mixed wastes in a modified sulfur cement composition. The waste may be incinerator fly ash or bottom ash including radioactive contaminants, toxic metal salts and other wastes commonly found in refuse. The process may use glass fibers mixed into the composition to improve the tensile strength and a low concentration of anhydrous sodium sulfide to reduce toxic metal solubility. The present invention preferably includes a method for encapsulating radioactive, hazardous and mixed wastes by combining substantially anhydrous wastes, molten modified sulfur cement, preferably glass fibers, as well as anhydrous sodium sulfide or calcium hydroxide or sodium hydroxide in a heated double-planetary orbital mixer. The modified sulfur cement is preheated to about C., then the remaining substantially dry components are added and mixed to homogeneity.
    Type: Grant
    Filed: November 7, 1994
    Date of Patent: October 14, 1997
    Assignee: Associated Universities, Inc.
    Inventors: Peter Colombo, Paul D. Kalb, John H. Heiser, III
  • Patent number: 5653957
    Abstract: A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: August 5, 1997
    Assignee: Associated Universities, Inc.
    Inventors: Michiko Miura, Daniel N. Slatkin
  • Patent number: 5650725
    Abstract: A magnetic imager 10 includes a generator 18 for practicing a method of applying a background magnetic field over a concealed object, with the object being effective to locally perturb the background field. The imager 10 also includes a sensor 20 for measuring perturbations of the background field to detect the object. In one embodiment, the background field is applied quasi-statically. And, the magnitude or rate of change of the perturbations may be measured for determining location, size, and/or condition of the object.
    Type: Grant
    Filed: September 1, 1995
    Date of Patent: July 22, 1997
    Assignee: Associated Universities, Inc.
    Inventors: James Powell, Morris Reich, Gordon Danby
  • Patent number: 5649323
    Abstract: The present invention provides a composition and process for disposal of radioactive, hazardous and mixed wastes. The present invention preferably includes a process for multibarrier encapsulation of radioactive, hazardous and mixed wastes by combining substantially simultaneously dry waste powder, a non-biodegradable thermoplastic polymer and an anhydrous additive in an extruder to form a homogenous molten matrix. The molten matrix may be directed in a "clean" polyethylene liner, allowed to cool, thus forming a monolithic waste form which provides a multibarrier to the dispersion of wastes into the environment.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: July 15, 1997
    Inventors: Paul D. Kalb, Peter Colombo
  • Patent number: 5639879
    Abstract: A simple method for the synthesis of 1,4,7, 10-tetraazacyclododecane N,N'N",N'"-tetraacetic acid and 1,4,8,11-tetraazacyclotetradecane N,N',N",N'"-tetraacetic acid involves cyanomethylating 1,4,7, 10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane to form a tetranitrile and hydrolyzing the tetranitrile. These macrocyclic compounds are functionalized through one of the carboxylates and then conjugated to various biological molecules including monoclonal antibodies. The resulting conjugated molecules are labeled with radiometals for SPECT and PET imaging and for radiotherapy.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: June 17, 1997
    Assignee: Associated Universities, Inc.
    Inventors: Ronnie C. Mease, Leonard F. Mausner, Suresh C. Srivastava
  • Patent number: 5635157
    Abstract: Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: June 3, 1997
    Inventors: Ronnie C. Mease, Kathryn L. Kolsky, Leonard F. Mausner, Suresh C. Srivastava