Abstract: This invention describes the use of polymerizable surfactants as comonomers in forming ophthalmic devices such as contact lenses, intraocular lenses, corneal implants, etc.

Abstract: Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising (a) a random copolymer comprising hydrophilic units and hydrophobic units, wherein the random copolymer has at least one thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (“RAFT”) agent are disclosed.

Abstract: Matrix controlled diffusion drug delivery systems based on one or more silicon-containing monomers of the general formula: wherein L, X?, n, R1, R2, R3, R4, R5, R6, R7 and V are as set forth herein.

Abstract: Matrix controlled diffusion drug delivery systems are described herein which are based on one or more silicon-containing monomers of the general formula: wherein L, X?, n, R1, R2, R3, R4, R5, R6, R7 and V are as set forth herein.

Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymer compositions comprise polymerized fluorinated polyether monomer end-capped with ethylenically unsaturated cationic hydrophilic groups.

Abstract: Processes for the purification of lercanidipine hydrochloride are provided which uses a binary system of an alcohol-containing solvent such as methanol and an aliphatic ester-containing solvent such as isopropyl acetate. Processes for the preparation of substantially amorphous lercanidipine hydrochloride are also provided. Also provided is lercanidipine hydrochloride substantially in polymorph form V.

Abstract: Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising an ethylenically unsaturated-containing non-amphiphilic macromonomer comprising hydrophilic units or hydrophobic units derived from a living radical polymerization of one or more ethylenically unsaturated hydrophilic monomers or one or more ethylenically unsaturated hydrophobic monomers are disclosed.

Abstract: Biomedical devices such as silicone hydrogels formed from a polymerization product of a mixture comprising (a) a siloxane-containing homopolymer comprising one or more thio carbonyl thio fragments of a reversible addition fragmentation chain transfer (RAFT) agent; and (b) one or more biomedical device-forming monomers are disclosed.

Abstract: Multi-armed macromonomers containing multiple side chains attached to a siloxy-containing core terminated on each end with one or more first substantially linear polysiloxane radicals having a polymerizable ethylenically unsaturated-containing terminal group, wherein each side chain comprises a second substantially linear polysiloxane radical having a polymerizable ethylenically unsaturated-containing terminal group are disclosed. Biomedical devices such as contact lenses formed from the multi-armed macromonomers are also disclosed.

Abstract: The present invention relates to hydrophilic dicationic siloxane prepolymers with one polymerizable vinyl moiety instead of two polymerizable vinyl moieties, resulting in contact lenses and/or biomedical devices with reduced cross-link density and modulus without detracting from other properties.

Abstract: This application is directed toward an improved method of synthesizing cationic siloxane prepolymers as well as a specific cationic siloxane prepolymer having improved compatibility with monofunctional siloxanyl methacrylate monomers and medical devices containing the cationic siloxane prepolymer.

Abstract: A stable colloidal suspension comprising: (a) a dispersed phase comprising a major amount of one or more dispersed hydrated polymeric compounds selected from the group consisting of polymolybdates, polytungstates, polyvanadates, polyniobates, polytantalates, polyuranates, and mixtures thereof, and, (b) an oil phase comprising one or more dispersing agents and a diluent oil. Processes for preparing the stable colloidal suspensions and their use in lubricating oil compositions are also provided.

Abstract: A lubricating oil composition comprising a base oil of lubricating viscosity having a kinematic viscosity of 22 to 300 mm2/s at 40° C. and dissolved or dispersed therein the following additives in the following amounts based on a total amount of the lubricating oil composition: (1) an overbased sulfurized alkylphenol calcium salt detergent in an amount of 0.1 to 1.6 wt. % in terms of calcium content, (2) an overbased calcium alkylbenzenesulfonate detergent in an amount of 0.6 to 2.1 wt. % in terms of calcium content, (3) a nitrogen-containing ashless dispersant in an amount of 0.005 to 0.1 wt. % in terms of nitrogen content, and (4) a zinc dihydrocarbyldithiophosphate in an amount of 0.01 to 0.1 wt.

Abstract: Disclosed herein is a lubricating oil composition comprising a) major amount of a base oil of lubricating viscosity; b) from about 0.1 to 10 wt % of an overbased alkaline earth metal alkyl aryl sulfonate detergent having a total base number (TBN) of about 25 to 500; c) from about 0.02 to 10 wt % of a oxymolybdenum-containing complex of a nitrogen-containing compound; d) from about 0.1 to 5 wt % of a friction modifier; and e) from about 0.2 to 10 wt % of an antioxidant selected from the group consisting of a diphenylamine type, a sulfurized ester-containing compound and mixtures thereof; wherein the total concentration of the oxymolybdenum-containing complex and antioxidant must be at least 1.3 wt %, based on the total weight of the lubricating oil composition and wherein the phosphorus content of the total lubricating oil composition is 0.08 wt % or less, based on the total weight of the lubricating oil composition.

Abstract: A gear oil additive composition and gear oil composition comprising a organic polysulfide having at least 30 wt % of a dialkyl polysulfide compound or mixture of dialkyl polysulfide compounds, a thiadiazole; and at least one ashless phosphorus-containing wear inhibitor compound is disclosed as having low yellow corrosion in axles and transmissions.

Abstract: Provided is a new and improved process for preparing a borated alkaline earth metal toluene sulfonate salt.

Abstract: Disclosed is a method for forming an antiwear film on an internal engine component comprising: contacting a surface of an internal wearing component of the engine with a tetra-functional hydrolyzable silane compound of the general formula Si—X4 or hydrolysis product thereof, wherein X is independently selected from the group consisting of hydroxyl, alkoxy, aryloxy, acyloxy, amino, monoalkyl amino and dialkyl amino; and hydrolyzing and condensing the tetra-functional silane to thereby form a film. Also disclosed are mixed silane films and the products produced by these methods.

Abstract: Esterified polyalkene/UAR copolymer reaction products useful as (1) a friction modifier for lubricating oils such as automatic transmission fluids to improve torque capacity and anti-shudder durability and for continuous variable transmissions (CVTs), (2) a friction modifier for fuels or (3) a cold flow improver for diesel fuels are provided. The esterified copolymer reaction product may be used as is or can be further derivatized (e.g., by post treatment of the esterified copolymer reaction product with, for example, ethylene carbonate or boric acid).

Abstract: A substantially pure dextrorotatory isomer of zopiclone or a pharmaceutically acceptable salt thereof and crystalline forms thereof are provided. Also provided is a process for its preparation and pharmaceutical compositions containing same.

Abstract: An oil-soluble lubricating oil additive composition prepared by the process which comprises reacting a copolymer, with at least one polyether aromatic compound, and with at least one polyether aliphatic compound.