Patents Represented by Attorney M. H. Silverstein

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  • Multiple embedded nuclear polyhedrosis virus from celery looper with activity against lepidoptera
    Patent number: 4911913
    Abstract: A multiple embedded nuclear polyhedrosis virus isolated from the celery looper, Syngrapha falcifera, was found to have broad insecticidal activity against lepidoptera species.
    Type: Grant
    Filed: March 7, 1989
    Date of Patent: March 27, 1990
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Donald L. Hostetter, Benjamin Puttler
  • Serotype 2 Marek's disease vaccine
    Patent number: 4895718
    Abstract: A serotype 2 Marek's disease vaccine comprising a cloned strain designated as 301B/1 has been derived from a field isolate. This strain is characterized by superior levels of replicative ability and protectivity in chickens as compared to existing commercial serotype 2 strains, and it is virtually nonpathogenic. 301B/1 is particularly useful in the formulation of highly efficacious bivalent and polyvalent vaccines.
    Type: Grant
    Filed: July 10, 1987
    Date of Patent: January 23, 1990
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventor: Richard L. Witter
  • Revertant serotype 1 Marek's disease vaccine
    Patent number: 4895717
    Abstract: A Marek's disease vaccine comprising either a revertant virus derived by backpassaging an attenuated serotype 1 Md11 virus or an antigenic component of the virus is characterized by increased levels of replicative ability and protectivity in chickens as compared to the original attenuated strain. Revertants of the invention are exemplified by a clone identified as Md11/75C/R2 and can be formulated into monovalent and polyvalent vaccines.
    Type: Grant
    Filed: July 10, 1987
    Date of Patent: January 23, 1990
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventor: Richard L. Witter
  • Use of boron supplements to increase in vivo production of hydroxylated steroids
    Patent number: 4849220
    Abstract: The oral administration of boron compounds such as sodium borate and boric acid increases the amounts of hydroxylated steroids in human plasma. This will help prevent or alleviate pathology, such as osteoporosis, caused by suboptimal circulating hydroxylated steroids such as 17.beta.-estradiol and testosterone.
    Type: Grant
    Filed: April 20, 1988
    Date of Patent: July 18, 1989
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Forrest H. Nielsen, Curtiss D. Hunt