Abstract: Compounds that selectively inhibit dipeptidyl peptidase-IV over closely related dipeptidyl peptidases are those of Formula (I): as well as pharmaceutically acceptable salts thereof, cyclic isomers thereof, prodrugs thereof, and solvates thereof, where all the variables are defined herein. These compounds can be used, alone or in combination with other drugs, for the treatment of diabetes and related diseases.

Abstract: Certain constrained cyano compounds are useful as inhibitors of post-proline/alanine cleaving amino-dipeptidases. Accordingly, these compounds can be employed, alone or with another therapeutic agent, to treat diabetes (especially, Type II diabetes), hyperglycemia, Syndrome X, diabetic complications, hyperinsulinemia, obesity, atherosclerosis and related diseases, as well as various immunomodulatory diseases and chronic inflammatory bowel disease.

Abstract: An optical proximity sensor for optically detecting an object within a predetermined detection volume. More specifically, an optical proximity sensor is disclosed having an illuminator assembly including an illuminator lens (55) and a plurality of light-emitting diodes (53) located at first predetermined positions along the focal plane (54) of the illuminator lens (55). A detector assembly including a detector lens (65) and a plurality of photodiodes (60) located at second predetermined positions along the focal plane of the detector lens (65) is also provided. The two lenses are spaced apart a predetermined distance in accordance with the configuration of the light-emitting diodes (53) and the photodiodes (60) in order to define a predetermined detection volume. Each light-emitting diode has a corresponding photodiode, and their relative positions on their respective focal planes determine the detection volume defined by their overlapping fields of view.