Patents Represented by Attorney MaCharri R. Vorndran-Jones

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  • Piperidine opioid antagonists
    Patent number: 5319087
    Abstract: This invention provides trans-3,4 1-substituted-3-substituted-4-methyl-4-(3-substituted phenyl)piperidines as opioid antagonists capable of blocking the mu or kappa receptors in the brain.
    Type: Grant
    Filed: September 3, 1992
    Date of Patent: June 7, 1994
    Assignee: Eli Lilly and Company
    Inventors: Dennis M. Zimmerman, Charles H. Mitch
  • Pyrazolidinone CCK and gastrin antagonists and pharmaceutical formulations thereof
    Patent number: 5300514
    Abstract: Novel substituted pyrazolidinones have been found to exhibit significant binding to cholecystokinin (CCK) receptors and gastrin receptors in the brain and/or peripheral sites such as the pancreas, stomach, and ileum. The pyrazolidinones are CCK and gastrin receptor antagonists and find therapeutic application in the treatment of gastrointestinal disorders, central nervous system disorders and for appetite regulation in warm-blood vertebrates. Pharmaceutical formulations for such indications are described.
    Type: Grant
    Filed: March 18, 1993
    Date of Patent: April 5, 1994
    Assignee: Eli Lilly and Company
    Inventors: Raymond F. Brown, J. Jeffry Howbert, Karen L. Lobb, David A. Neel, Jon K. Reel, Beverley Greenwood
  • Tetrahydro-pyrido-indole
    Patent number: 5300645
    Abstract: The present invention provides a new Pictet-Spengler process useful for preparing tetrahydro-beta-carboline compounds.
    Type: Grant
    Filed: April 14, 1993
    Date of Patent: April 5, 1994
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, James J. Droste, Deborah A. Evrard
  • Peripherally selective piperidine opioid antagonists
    Patent number: 5270328
    Abstract: N-alkylamino-3,4,4-substituted piperidines are provided which are useful as peripheral opioid antagonists.
    Type: Grant
    Filed: June 29, 1992
    Date of Patent: December 14, 1993
    Assignee: Eli Lilly and Company
    Inventors: Buddy E. Cantrell, Dennis M. Zimmerman
  • Pyrroloazepine compounds useful as dopaminergic agents
    Patent number: 5258378
    Abstract: The invention relates to a compound of formula (I) ##STR1## in which R.sup.1 and R.sup.2 are each hydrogen, halo, hydroxy, nitro, C.sub.1-4 alkylcarbonyl, hydroxy-C.sub.1-4 alkyl, R.sup.3 is hydrogen or optionally substituted phenylsulphonyl, R.sup.4 is optionally substituted phenyl, benzofuranyl or dihydrobenzofuranyl, and R.sup.5 is hydrogen or C.sub.1-4 alkyl; and salts thereof. These compounds are useful dopaminergic agents.
    Type: Grant
    Filed: November 19, 1991
    Date of Patent: November 2, 1993
    Assignee: Lilly Industries Limited
    Inventors: Barry P. Clark, Graham H. Timms, David E. Tupper
  • Peripherally selective piperidine carboxylate opioid antagonists
    Patent number: 5250542
    Abstract: 3,4,4-trisubstitutedpiperidinyl-N-alkylcarboxylates and intermediates for their preparation are provided. These piperidine-N-alkylcarboxylates are useful as peripheral opioid antagonists.
    Type: Grant
    Filed: July 17, 1992
    Date of Patent: October 5, 1993
    Assignee: Eli Lilly and Company
    Inventors: Buddy E. Cantrell, Dennis M. Zimmerman
  • 2-methyl-thieno-benzodiazepine
    Patent number: 5229382
    Abstract: 2-Methyl-10-(4-methyl-1-piperazinyl)-4H-thieno-[2,3-b][1,5]benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: May 22, 1992
    Date of Patent: July 20, 1993
    Assignee: Lilly Industries Limited
    Inventors: Jiban K. Chakrabarti, Terrence M. Hotten, David E. Tupper