Patents Represented by Law Firm MacMillan, Sobanski and Todd
-
Patent number: 8349560Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.Type: GrantFiled: October 17, 2011Date of Patent: January 8, 2013Assignee: The Ohio State University ResearchInventor: Carlo M. Croce
-
Patent number: 8349561Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.Type: GrantFiled: October 17, 2011Date of Patent: January 8, 2013Assignee: The Ohio State University Research FoundationInventor: Carlo M. Croce
-
Patent number: 8349568Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 14, 2011Date of Patent: January 8, 2013Assignees: The Ohio State University Research Foundation, The United States of America, as Represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
-
Patent number: 8343725Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 15, 2011Date of Patent: January 1, 2013Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
-
Patent number: 8346428Abstract: The invention concerns an electronic vehicle dynamics regulation system for a land vehicle, which system is set up for steering and braking intervention, and with which a sensor arrangement is associated, which sensor arrangement, for a steering intervention device and for a braking system which builds up braking forces independently of or in addition to the driver, captures the yaw angular velocity and/or the transverse acceleration and feeds them to the steering intervention device and braking system.Type: GrantFiled: October 12, 2006Date of Patent: January 1, 2013Assignee: Lucas Automotive GmbHInventor: Josef Knechtges
-
Patent number: 8343201Abstract: A pedicle screw assembly has a retractable screw tip that facilitates the securement of the pedicle screw assembly to a spinal vertebra in a minimally invasive fashion during an orthopedic surgical procedure. The pedicle screw assembly includes a body portion including a head and a shank. The shank includes an outer surface with a thread provided thereon, an end having a cutting tip provided thereon, and a bore extending inwardly from the end and having an internally threaded region provided therein. The pedicle screw assembly also includes a tip portion including a body having a cutting edge and a shank extending from the body. The shank has an externally threaded region provided thereon that cooperates with the internally threaded region of the bore to permit movement of the tip portion relative to the body portion between extended and retracted positions.Type: GrantFiled: August 4, 2009Date of Patent: January 1, 2013Assignee: The University of ToledoInventors: Ashok Biyani, Gary Durivage
-
Patent number: 8336424Abstract: A control knob assembly includes a housing and a knob mounted for rotary motion on the housing about a pivot axis. A cursor is mounted on the knob and spaced from the pivot axis. The cursor moves in a circular path as the knob is rotated. The assembly further includes a plurality of sensors spaced in a linear arrangement along a linear axis. Each of the sensors generates a signal upon detection of the presence of the cursor when the cursor is adjacent the sensor as the cursor moves along its circular path. The signal is representative of an angular position of the knob relative to the housing.Type: GrantFiled: September 7, 2007Date of Patent: December 25, 2012Assignee: Lear CorporationInventors: Josep Jacas Miret, Alberto Garcia Briz
-
Patent number: 8338105Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 15, 2011Date of Patent: December 25, 2012Assignees: The Ohio State University Research Foundation, The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TansferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
-
Patent number: 8338616Abstract: The present invention relates to a composition of a thiazolium compound of formula I or a solvate thereof, wherein the definitions of groups in the formula I are as those given in the claims:Type: GrantFiled: September 15, 2009Date of Patent: December 25, 2012Assignee: Beijing Molecule Science And Technology Co., Ltd.Inventors: Song Li, Wu Zhong, Lili Wang, Zhibing Zheng, Hao Cui, Junhai Xiao, Gang Cheng, Yunde Xie, Bing Zhang
-
Patent number: 8337056Abstract: An enclosure for a recessed light in an attic is transformable between a first configuration in which the enclosure is flat and a second configuration in which the enclosure defines a housing. The housing has an opening at a bottom end for receiving the recessed light and an upwardly-facing surface opposite the opening. The upwardly-facing surface has a variable height relative to the bottom end.Type: GrantFiled: February 3, 2010Date of Patent: December 25, 2012Assignee: Owens Corning Intellectual Capital, LLCInventors: Harry A. Alter, Anthony L. Rockwell
-
Patent number: 8337412Abstract: A device for dissecting and/or harvesting a vessel includes an integrally adjustable insufflation device to supply an insufflation fluid to a subcutaneous area within a patient. The integrally adjustable insufflation device includes one or more one fluid control mechanisms to regulate the pressure rate and/or flow rate of the insufflation fluid being supplied to the subcutaneous area from within a sterile field surrounding the subcutaneous area.Type: GrantFiled: November 29, 2007Date of Patent: December 25, 2012Assignees: Terumo Cardiovascular Systems Corporation, Olympus Medical Systems CorporationInventors: Kay L. Fuller, Randal J. Kadykowski
-
Patent number: 8338102Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 14, 2011Date of Patent: December 25, 2012Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
-
Patent number: 8338103Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 14, 2011Date of Patent: December 25, 2012Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Deparment of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
-
Patent number: 8338106Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 15, 2011Date of Patent: December 25, 2012Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
-
Patent number: 8336908Abstract: An automotive air bag system for a vehicle includes an instrument panel substrate comprised a first moldable thermoplastic characterized by a first melting temperature. The instrument panel substrate has a substantially smooth outer surface for facing a passenger compartment of the vehicle. A chute is comprised a second moldable thermoplastic characterized by a second melting temperature lower than the first melting temperature. The chute includes an in-mold tear seam and a hinge for an air bag deployment door and a passageway for guiding an inflating air bag to the deployment door. The chute is attached to an inner surface of the instrument panel substrate by insert molding in which injection of the first moldable thermoplastic causes a partial melting of the second moldable thermoplastic.Type: GrantFiled: August 8, 2011Date of Patent: December 25, 2012Assignee: Ford Global Technologies, LLCInventors: Raymond E. Kalisz, Kenneth J. Kwasnik
-
Patent number: 8336910Abstract: An active bolster is provided on an generally-planar interior trim panel. An invisible tear seam in the panel follows a closed path that is spaced away from a peripheral edge of the panel. An inflatable bladder has a rim bonded to the panel along an inward edge of the tear seam. A bowl-shaped reaction frame has a cavity receiving the inflatable bladder and has a rim bonded to the panel along an outward edge of the tear seam, so that the inflatable bladder is contained between the reaction frame and the interior trim panel. Inflation of the inflatable bladder causes the interior trim panel to tear at the tear seam causing the portion of the interior trim panel within the closed path to separate and expand away from the reaction frame into the passenger compartment.Type: GrantFiled: October 3, 2011Date of Patent: December 25, 2012Assignee: Ford Global Technologies, LLCInventors: Raymond E. Kalisz, Michael G. Orlowsky
-
Patent number: 8338104Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 15, 2011Date of Patent: December 25, 2012Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
-
Patent number: 8328230Abstract: An active bolster for protecting an occupant during a crash event of a motor vehicle includes a back wall and a front wall forming an inflatable bladder. Frangible tear ribs are provided in a central region to limit expansion so a surrounding region expands by a greater distance toward the occupant prior to tearing of the tear ribs providing a contoured shape during inflation deflecting a portion of an impacting occupant toward the central region. The tear ribs separate after a predetermined amount of inflation to provide a cushion in the central region.Type: GrantFiled: January 30, 2012Date of Patent: December 11, 2012Assignee: Ford Global Technologies, LLCInventor: Raymond E. Kalisz
-
Patent number: 8328123Abstract: A machine for distributing loosefill insulation from sources of compressed loosefill insulation is provided. The machine includes a shredding chamber having an outlet end and a plurality of shredders configured to condition the loosefill insulation. The plurality of shredders is configured to operate at variable rotational speeds. A discharge mechanism is mounted at the outlet end of the shredding chamber. The discharge mechanism is configured for distributing the conditioned loosefill insulation into an airstream provided by a blower. The blower is configured to operate at variable rotational speeds. The plurality of shredders, the discharge mechanism and the blower are configured to operate on a single 15 ampere, 110 volt a.c. power supply. The variable rotational speeds of the plurality of shredders are configured to provide variable flow rates of the loosefill insulation and the variable rotational speeds of the blower are configured to provide variable flow rates of the airstream.Type: GrantFiled: September 23, 2010Date of Patent: December 11, 2012Assignee: Owens Corning Intellectual Capital, LLCInventors: Michael E. Evans, Christopher M. Relyea
-
Patent number: D672619Type: GrantFiled: May 31, 2012Date of Patent: December 18, 2012Assignee: Robert Welch Designs LimitedInventor: Kit deBretton Gordon