Patents Represented by Attorney, Agent or Law Firm MacMillan, Sobanski & Todd, LLC
  • Patent number: 8349560
    Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: January 8, 2013
    Assignee: The Ohio State University Research
    Inventor: Carlo M. Croce
  • Patent number: 8349568
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: January 8, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America, as Represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Patent number: 8349561
    Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: January 8, 2013
    Assignee: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce
  • Patent number: 8346428
    Abstract: The invention concerns an electronic vehicle dynamics regulation system for a land vehicle, which system is set up for steering and braking intervention, and with which a sensor arrangement is associated, which sensor arrangement, for a steering intervention device and for a braking system which builds up braking forces independently of or in addition to the driver, captures the yaw angular velocity and/or the transverse acceleration and feeds them to the steering intervention device and braking system.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: January 1, 2013
    Assignee: Lucas Automotive GmbH
    Inventor: Josef Knechtges
  • Patent number: 8343725
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: January 1, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Patent number: 8343201
    Abstract: A pedicle screw assembly has a retractable screw tip that facilitates the securement of the pedicle screw assembly to a spinal vertebra in a minimally invasive fashion during an orthopedic surgical procedure. The pedicle screw assembly includes a body portion including a head and a shank. The shank includes an outer surface with a thread provided thereon, an end having a cutting tip provided thereon, and a bore extending inwardly from the end and having an internally threaded region provided therein. The pedicle screw assembly also includes a tip portion including a body having a cutting edge and a shank extending from the body. The shank has an externally threaded region provided thereon that cooperates with the internally threaded region of the bore to permit movement of the tip portion relative to the body portion between extended and retracted positions.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: January 1, 2013
    Assignee: The University of Toledo
    Inventors: Ashok Biyani, Gary Durivage
  • Patent number: 8338102
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Patent number: 8336908
    Abstract: An automotive air bag system for a vehicle includes an instrument panel substrate comprised a first moldable thermoplastic characterized by a first melting temperature. The instrument panel substrate has a substantially smooth outer surface for facing a passenger compartment of the vehicle. A chute is comprised a second moldable thermoplastic characterized by a second melting temperature lower than the first melting temperature. The chute includes an in-mold tear seam and a hinge for an air bag deployment door and a passageway for guiding an inflating air bag to the deployment door. The chute is attached to an inner surface of the instrument panel substrate by insert molding in which injection of the first moldable thermoplastic causes a partial melting of the second moldable thermoplastic.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: December 25, 2012
    Assignee: Ford Global Technologies, LLC
    Inventors: Raymond E. Kalisz, Kenneth J. Kwasnik
  • Patent number: 8338104
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Patent number: 8338106
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Patent number: 8336424
    Abstract: A control knob assembly includes a housing and a knob mounted for rotary motion on the housing about a pivot axis. A cursor is mounted on the knob and spaced from the pivot axis. The cursor moves in a circular path as the knob is rotated. The assembly further includes a plurality of sensors spaced in a linear arrangement along a linear axis. Each of the sensors generates a signal upon detection of the presence of the cursor when the cursor is adjacent the sensor as the cursor moves along its circular path. The signal is representative of an angular position of the knob relative to the housing.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: December 25, 2012
    Assignee: Lear Corporation
    Inventors: Josep Jacas Miret, Alberto Garcia Briz
  • Patent number: 8338103
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Deparment of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Patent number: 8338616
    Abstract: The present invention relates to a composition of a thiazolium compound of formula I or a solvate thereof, wherein the definitions of groups in the formula I are as those given in the claims:
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: December 25, 2012
    Assignee: Beijing Molecule Science And Technology Co., Ltd.
    Inventors: Song Li, Wu Zhong, Lili Wang, Zhibing Zheng, Hao Cui, Junhai Xiao, Gang Cheng, Yunde Xie, Bing Zhang
  • Patent number: 8336910
    Abstract: An active bolster is provided on an generally-planar interior trim panel. An invisible tear seam in the panel follows a closed path that is spaced away from a peripheral edge of the panel. An inflatable bladder has a rim bonded to the panel along an inward edge of the tear seam. A bowl-shaped reaction frame has a cavity receiving the inflatable bladder and has a rim bonded to the panel along an outward edge of the tear seam, so that the inflatable bladder is contained between the reaction frame and the interior trim panel. Inflation of the inflatable bladder causes the interior trim panel to tear at the tear seam causing the portion of the interior trim panel within the closed path to separate and expand away from the reaction frame into the passenger compartment.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: December 25, 2012
    Assignee: Ford Global Technologies, LLC
    Inventors: Raymond E. Kalisz, Michael G. Orlowsky
  • Patent number: 8337412
    Abstract: A device for dissecting and/or harvesting a vessel includes an integrally adjustable insufflation device to supply an insufflation fluid to a subcutaneous area within a patient. The integrally adjustable insufflation device includes one or more one fluid control mechanisms to regulate the pressure rate and/or flow rate of the insufflation fluid being supplied to the subcutaneous area from within a sterile field surrounding the subcutaneous area.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: December 25, 2012
    Assignees: Terumo Cardiovascular Systems Corporation, Olympus Medical Systems Corporation
    Inventors: Kay L. Fuller, Randal J. Kadykowski
  • Patent number: 8337056
    Abstract: An enclosure for a recessed light in an attic is transformable between a first configuration in which the enclosure is flat and a second configuration in which the enclosure defines a housing. The housing has an opening at a bottom end for receiving the recessed light and an upwardly-facing surface opposite the opening. The upwardly-facing surface has a variable height relative to the bottom end.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: December 25, 2012
    Assignee: Owens Corning Intellectual Capital, LLC
    Inventors: Harry A. Alter, Anthony L. Rockwell
  • Patent number: 8338105
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Tansfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Patent number: 8327981
    Abstract: The invention relates to a ball screw for a motor vehicle brake, in particular for an electromechanically actuable motor vehicle brake, comprising a rotatable spindle; a nut that is axially movable relative to the spindle in accordance with the rotation thereof; and rolling body arrangement that is disposed between, and displaceable relative to, the spindle and the nut. In this ball screw it is provided that the rolling body arrangement is preloaded into a predetermined normal position by means of at least one spring element. The invention further relates to a vehicle brake having such a ball screw.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: December 11, 2012
    Assignee: Lucas Automotive GmbH
    Inventors: Wilfried Giering, Benedikt Ohlig
  • Patent number: 8328233
    Abstract: An active bolster for an automotive vehicle includes a bladder that inflates an interior trim area of the vehicle to provide a cushion to an occupant during a crash. The bladder has a front panel and a back panel joined to the front panel defining an inflatable cavity. The back panel has a variable vent for venting inflation gas supplied into the cavity during a crash event. The vent has a first predetermined flow coefficient when a pressure difference across the vent is substantially zero and a greater flow coefficient when there is a predetermined pressure difference across the vent. Little gas is lost during an inflation phase while sufficient venting is obtained during an impact phase.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: December 11, 2012
    Assignee: Ford Global Technologies, LLC
    Inventor: Raymond E. Kalisz
  • Patent number: D672619
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: December 18, 2012
    Assignee: Robert Welch Designs Limited
    Inventor: Kit deBretton Gordon