Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.

Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.

Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.

Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.

Abstract: The invention concerns an electronic vehicle dynamics regulation system for a land vehicle, which system is set up for steering and braking intervention, and with which a sensor arrangement is associated, which sensor arrangement, for a steering intervention device and for a braking system which builds up braking forces independently of or in addition to the driver, captures the yaw angular velocity and/or the transverse acceleration and feeds them to the steering intervention device and braking system.

Abstract: A pedicle screw assembly has a retractable screw tip that facilitates the securement of the pedicle screw assembly to a spinal vertebra in a minimally invasive fashion during an orthopedic surgical procedure. The pedicle screw assembly includes a body portion including a head and a shank. The shank includes an outer surface with a thread provided thereon, an end having a cutting tip provided thereon, and a bore extending inwardly from the end and having an internally threaded region provided therein. The pedicle screw assembly also includes a tip portion including a body having a cutting edge and a shank extending from the body. The shank has an externally threaded region provided thereon that cooperates with the internally threaded region of the bore to permit movement of the tip portion relative to the body portion between extended and retracted positions.

Abstract: The present invention relates to a composition of a thiazolium compound of formula I or a solvate thereof, wherein the definitions of groups in the formula I are as those given in the claims:

Abstract: A control knob assembly includes a housing and a knob mounted for rotary motion on the housing about a pivot axis. A cursor is mounted on the knob and spaced from the pivot axis. The cursor moves in a circular path as the knob is rotated. The assembly further includes a plurality of sensors spaced in a linear arrangement along a linear axis. Each of the sensors generates a signal upon detection of the presence of the cursor when the cursor is adjacent the sensor as the cursor moves along its circular path. The signal is representative of an angular position of the knob relative to the housing.

Abstract: An active bolster is provided on an generally-planar interior trim panel. An invisible tear seam in the panel follows a closed path that is spaced away from a peripheral edge of the panel. An inflatable bladder has a rim bonded to the panel along an inward edge of the tear seam. A bowl-shaped reaction frame has a cavity receiving the inflatable bladder and has a rim bonded to the panel along an outward edge of the tear seam, so that the inflatable bladder is contained between the reaction frame and the interior trim panel. Inflation of the inflatable bladder causes the interior trim panel to tear at the tear seam causing the portion of the interior trim panel within the closed path to separate and expand away from the reaction frame into the passenger compartment.

Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.

Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.

Abstract: An enclosure for a recessed light in an attic is transformable between a first configuration in which the enclosure is flat and a second configuration in which the enclosure defines a housing. The housing has an opening at a bottom end for receiving the recessed light and an upwardly-facing surface opposite the opening. The upwardly-facing surface has a variable height relative to the bottom end.

Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.

Abstract: A device for dissecting and/or harvesting a vessel includes an integrally adjustable insufflation device to supply an insufflation fluid to a subcutaneous area within a patient. The integrally adjustable insufflation device includes one or more one fluid control mechanisms to regulate the pressure rate and/or flow rate of the insufflation fluid being supplied to the subcutaneous area from within a sterile field surrounding the subcutaneous area.

Abstract: An automotive air bag system for a vehicle includes an instrument panel substrate comprised a first moldable thermoplastic characterized by a first melting temperature. The instrument panel substrate has a substantially smooth outer surface for facing a passenger compartment of the vehicle. A chute is comprised a second moldable thermoplastic characterized by a second melting temperature lower than the first melting temperature. The chute includes an in-mold tear seam and a hinge for an air bag deployment door and a passageway for guiding an inflating air bag to the deployment door. The chute is attached to an inner surface of the instrument panel substrate by insert molding in which injection of the first moldable thermoplastic causes a partial melting of the second moldable thermoplastic.

Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.

Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.

Abstract: A wheelchair comprises a base frame, a backrest frame and a hinge assembly. The base frame has first and second side frame members. The hinge assembly connects the backrest frame to a portion of the base frame for selective pivotal movement. The hinge assembly includes a locking mechanism configured to provide selective discrete locking positions of the backrest relative to the base frame. The locking mechanism includes a locking pin and a plurality of cooperating locking apertures. The locking pin is adapted to selectively engage one of the plurality of locking apertures to define a backrest angle relative to the base frame. One or more plugs are adapted to engage one or more of the plurality of locking apertures to prevent the locking pin from cooperating with the plugged locking aperture.

Abstract: The present invention relates to an optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, a process for preparing the optically pure compound of formula (I), and use of the optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.