Abstract: The present invention relates to a medication delivery device comprising a cartridge assembly, a dosing assembly and optionally a needle assembly. The cartridge assembly comprises a cartridge having a stopper adapted to receive a plunger means. Furthermore, the cartridge assembly has one end sealed with a pierceable sealing, said end comprising coupling means for engaging a needle assembly, and another end comprising coupling means for engaging the dosing assembly. At least one of the coupling means of the cartridge assembly is unitarily moulded with the cartridge. The dosing assembly comprises a plunger means and has coupling means for engaging the cartridge assembly. The cartridge assembly and the dosing assembly are coupled together for delivering selected doses of medication. The cartridge is preferably moulded from a plastic material, such as a transparent material, and may be housed in a cartridge housing for protection of the cartridge.

Abstract: A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism, such as dyslipidemia, and obesity.

Abstract: Analysis of full-blood glucose, serum insulin, serum triglycerides and total serum cholesterol were performed. Glucose levels in blood samples from the oral glucose tolerance test were used for calculation of the incremental Area Under the Curve (AUC0-120 min−baseline). All data are expressed as percentage change of vehicle treated animals (cf. FIGS. 1 and 2).

Abstract: A dose display for a medicine administration device in which rotation of a dose setting actuator (22) is transmitted to a display means comprises a flexible disc (23) carrying numbers in a band along its perimeter, which numbers are in accordance with the set dose presented in a window in a wall of the device to show said dose. During its rotation the disc (23) is deflected to follow an inner contour of the device to attain a cylindrical shape having a generatrix extending in the axial direction of the injection device and perpendicular to the axis of rotation of the disc.

Abstract: A disposable double pointed injection needle has a needle hub to which a thin needle cannula is permanently fasten and which needle hub can be mounted on to a syringe comprising a dose setting and injection mechanism and a cartridge containing a liquid medicine to be injected subcutaneously into a human body. The needle hub is provided with a safety shield guided on the outside surface of the needle hub. The safety shield is urged in a direction away from the needle hub by a spring located between the needle hub and the safety shield. The safety shield has a number of protrusions guided in guiding tracks on the outside surface of the needle hub. The guiding tracks are designed such that the safety shield during injection is moved towards the needle hub, and after injection is moved away from the needle hub by the spring and locked in an irreversible position where the safety shield covers the needle cannula and prevents accidental needle stick injuries.

Abstract: This invention relates to an system for self treatment. The system consists of several portable modules where one of the modules is designated as a master module. The master module controls, supervises and monitors all the mutual information and data exchange between itself and the rest of the modules. The modules can e.g. consist of a BGM, a doser, an inhaler, a tablet dispenser and a storage container. The modules may be able to generate and store data which is transmitted to the master module if it is within range and active. If the master module is not within range, the data is kept locally in the module until the master module is available or a new master module is designated. The master module or another specific module can send the data to an external unit like a computer or database for further processing. A physician or an expert care-team can access the data in the database and give guidance to the patient on the basis of these processed data.

Abstract: The invention relates to: A portable medication delivery device (1) comprising a medication cartridge (11) having an outlet (111) and a movable piston (112), and a housing (12) for holding said cartridge, and a flexible piston rod (13) being operable to engage and displace said piston along an axis (113) of said cartridge, and guiding means (14) for bending said piston rod away from said axis, and actuating means (15), and driving means (16, 17) for transferring movement from said actuating means to said piston rod, said driving means including a driving wheel (17) for displacing the piston rod (13), said flexible piston rod comprising regularly spaced first members (330; 331; 332) adapted to mechanically cooperate with corresponding second members (171) on said driving wheel. The object of the present invention is to provide a medication delivery system that combines compactness with an improved accuracy.

Abstract: An automatic needle insertion device for a pen shaped syringe comprising a cartridge holder (2) wherein a cartridge with a drug can be accommodated, and a dose setting and injection part (1) by which a wanted dose may be set an subsequently pressed out from the cartridge by pressing a button (12) projecting from the dose setting and injection part (1). The device comprises a mainly tubular housing (31) in which a tubular pen holder (22) in which a pen can be mounted can be axially displaced in a proximal direction to cock a spring (30) which can thereafter be released to drive the pen holder (22) with the pen a set distance in a distal direction.

Abstract: A cartridge (1) for an injection device carries a code represented by a number of bars (2, 3, 4, 5) mainly perpendicular to the axis of the cartridge. The bars (2, 3, 4, 5) are mainly transparent and are each along its whole length provided with an optical grating which diffracts and reflects light impinging the surface carrying the code so that a minor part of this light is reflected from the surface of the bar as a set of light beams of which beams at least one is detected for the indication of the presence of the bar when said bar passes a reading light field. The reflections from the bars may be interpreted as representing “1”s and “0”s in a binary code.

Abstract: Described is a dose setting limiter for medical injectors of the type having a housing accommodating an ampoule-containing medicine sufficient for a number of dosed injections, a rotary dose setting knob, which is rotational relative to the housing and by which doses may be set by rotating the dose setting knob and an injection button which, when activated, administers the set dose. The dose setting limiter includes a stationary first part connected to the housing, and a second part fitted over the rotary dose setting knob, the second part being able to rotate together with the dose setting knob when setting up a dose and the second part being rotational relative to the first part. A third part is placed between the first part and the second part, the third part having means cooperating with means on the second part for limiting the dose setting.

Abstract: A medication delivery device comprising a container containing a fluid medicament. The medicament is expelled from the container by moving forward an elastomeric piston inside the cartridge. The piston is moved forward by a telescopic piston rod, which can either be centrally located in the container or eccentric located. One end of the telescopic piston rod abuts the elastomeric piston either by itself or through an additional plate. The abutment having a friction large enough to prevent a lower part of the telescopic rod from rotating. In order to prevent the elastomeric piston from rotating inside the container a second telescopic piston rod is provided parallel with the first telescopic piston rod.

Abstract: A cassette for storing and insertion of a solid medicine peg appears as a unit having a first bore (2) which accommodates the medicine peg (3) and has a diameter corresponding to the diameter of this peg (3), a second bore (4) in coaxial extension of the first bore (2) and having a diameter larger than the diameter of the first bore (2), an inserter having a shaft (5) fitting into the first bore (2) and a guiding head (6) in coaxial extension of the shaft (5) fitting into the second bore. The inserter shaft (5) has one end adjacent to the peg (3) and the other connected to the guiding head (6) which projects from the cassette. The head (6) fits into the second bore with a fitting providing a diffusion tight sealing and the distal end of the unit is closed by a membrane diffusion tightly sealing this distal end.

Abstract: A flexible piston rod for an injection device, which piston has the form of a helical spring made from a number of narrowly adjacent turns of windings. These turns provide an external thread fitting into the internal thread of a nut element. When the nut element is rotated, the piston rod is advanced forward, which movement is used to displace a piston inside a cartridge containing a fluid to be expelled. In order to prevent the piston rod from rotating when the nut element is rotated, the helical spring making up the piston rod is provided with a longitudinal spine, which is located at a peripheral area of the helical spring.