Abstract: Stabilized ubiquitin-lytic peptide fusion polypeptides and a method of making the same by sub-cloning nucleic acid sequences coding for lytic peptides into a plasmid vector comprising a promoter and ubiquitin polypeptide coding sequence, wherein the ubiquitin polypeptide sequence is linked to the 5′ end of the lytic peptide nucleic acid sequence and is translated as a fusion polypeptide.
Type:
Grant
Filed:
January 14, 2000
Date of Patent:
September 10, 2002
Assignees:
The United States of America as represented by the Secretary
of Agriculture, Demegen, Inc.