Abstract: An improved combined washer and aspirator device comprises improved tips, tip seals, reaction well seals and a frame. The improved device reduces the amount of manual dexterity required of a laboratory technologist to wash beads in reaction wells used in diagnostic immunoassays.

Abstract: An improved enteral nutritional hypoallergenic formula is disclosed. The formula contains carbohydrates, lipids, protein hydrolysate, vitamins and minerals and a starch modified by octenyl succinic anhydride which is utilized as the sole lipid emulsifying agent to provide a nutritionally well-balanced dietary formula.

Abstract: This disclosure relates to a method and reagents for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure and to a novel class of tracer compounds employed as reagents in such procedures. The procedure disclosed combines the specificity of an immunoassay with the speed and convenience of fluorescence polarization techniques to provide a means for determining the amount of the specific ligand present in a sample.

Abstract: This invention involves an improvement in immunoassay for carcinoembryonic antigen in biological fluids. The improvement comprises liberating carcinoembryonic antigen in the biological fluid by diluting the biological fluid with about 0.4-0.8 molar salt solution buffered at about pH 6-8 prior to conducting the immunoassay for carcinoembryonic antigen.

Abstract: A secondary package is provided for the purpose of enclosing and protecting a primary package in the form of a flexible pouch of liquid provided with access ports. The secondary package has internal divider ridges which distribute and dissipate the shock of impact, and at least one set of which is located nearer to the port end of the secondary package so as to protect the relatively vulnerable port area. Additional protective features of the secondary package include the use of a shock-absorbing material, and the provision of shock-absorbing flanges and spacer feet, and releasably locking detents for securing the secondary package in a closed condition.

Abstract: Carbamazepine-thiophosphonate conjugates for use as enzyme inhibitors having the formula: ##STR1## wherein Z is a biologically compatible counter ion, n is an integer from 2 to 6 and R and R.sub.1 are each lower alkyl.

Abstract: The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction.The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method.

Abstract: Phenobarbital conjugates for use as enzyme inhibitors having the formula: ##STR1## wherein Z is a biologically compatible counter ion, n and m is an integer from 2 to 6 and R and R.sub.1 are each lower alkyl.