Patents Represented by Attorney Marian T. Thomson
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Patent number: 6054613Abstract: A process for the preparation of a sulfonamide of formula:RSO.sub.2 NR.sup.1 R.sup.2wherein R represents C.sub.1 -C.sub.10 alkyl; andR.sup.1 and R.sup.2 independently represent hydrogen, C.sub.1 -C.sub.10 alkyl or C.sub.6 -C.sub.10 aryl; which comprises reacting the corresponding alkane- or arenesulfonyl halide of formula:RSO.sub.2 Halwherein Hal represents halogen; with the corresponding compound of formula:NHR.sup.1 R.sup.2in an aqueous solvent and extracting the sulfonamide from the resulting mixture into a polar organic solvent.Type: GrantFiled: May 24, 1999Date of Patent: April 25, 2000Assignee: Zeneca LimitedInventors: Brian David Gott, James Peter Muxworthy, Stephen Martin Brown
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Patent number: 6022976Abstract: A process for the production of hydroxy-substituted oxazolidinones, particularly 5-hydroxyoxazolidinones, which are useful as intermediates in the synthesis of herbicidally active compounds, comprising treating a hydroxythiazolidinone with an oxidizing agent.Type: GrantFiled: July 28, 1998Date of Patent: February 8, 2000Assignee: ZENECA LimitedInventors: Glynn Mitchell, John Michael Cox, Shaheen Khatoon Vohra
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Patent number: 5985630Abstract: An assay for detecting inhibitors of amino acyl-tRNA synthetases by incubating a divalent metal cation, ATP, tRNA, a non-cognate amino acid, inorganic pyrophosphatase and aminoacyl-tRNA synthetase, which aminoacyl-tRNA synthetase is in at least a partially pure form, both with and without a potential inhibitor, converting the resulting pyrophosphate to phosphate, detecting phosphate production, and comparing the phosphate production results obtained.Type: GrantFiled: August 5, 1997Date of Patent: November 16, 1999Assignee: Zeneca LimitedInventor: Timothy Robert Hawkes
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Patent number: 5973159Abstract: 2-Hydroxy-6-trifluoromethylpyridine is prepared by reacting 2-chloro-6-trifluoromethylpyridine with an aqueous alkali metal hydroxide in a sealed vessel at a temperature of at least 140.degree. C. under autogenous pressure.Type: GrantFiled: February 23, 1998Date of Patent: October 26, 1999Assignee: Zeneca LimitedInventors: Ian Andrew Lilley, Raymond Vincent Heavon Jones, Stephen Martin Brown
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Patent number: 5942509Abstract: Fungicidal compounds having the formula (I): ##STR1## in which any two of K, L and M are nitrogen and the other is CA wherein A is H, halogen, C.sub.1-4 alkyl, cyano, nitro or trifluoromethyl; X is a linking group other than oxygen; T is oxygen or sulphur; and Z is an optionally substituted carbocyclic or heterocyclic ring.Type: GrantFiled: January 31, 1997Date of Patent: August 24, 1999Assignee: Zeneca LimitedInventors: John Martin Clough, Christopher Richard Ayles Godfrey, Paul John De Fraine, Ian Thomas Streeting, Gordon Richard Munns
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Patent number: 5939563Abstract: Compounds of formula (XXIII): ##STR1## wherein p is 0 or 1, and processes for making such compounds.Type: GrantFiled: March 30, 1998Date of Patent: August 17, 1999Assignee: ZENECA LimitedInventor: Ian Richard Matthews
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Patent number: 5925795Abstract: This invention relates to processes for the preparation of aryl-.beta.-diketones and aryl-pyrimidine ketones. In addition, this invention relates to the preparation of aryl-.beta.-triketones and dimethyl aminomethylene .beta.-diketones, which are useful as crop protection intermediates.Type: GrantFiled: September 16, 1996Date of Patent: July 20, 1999Assignee: Zeneca LimitedInventors: Raymond A. Felix, Hsiao-Ling M. Chin, Frank X. Woolard, David L. Lee
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Patent number: 5922644Abstract: A herbicidal compound of formula (I) ##STR1## or a salt, tautomer or cyclic derivative thereof; where R.sup.1 and R.sup.2 are hydrogen and A is an optionally substituted saturated or unsaturated chain or ring of three carbon atoms.Methods for preparing these compounds, intermediates used in the preparation and herbicidal compositions containing them are also described and claimed.Type: GrantFiled: September 28, 1994Date of Patent: July 13, 1999Assignee: Zeneca LimitedInventors: John Michael Cox, Peter Bellini, Roger Barrett, Russell Martin Ellis, Timothy Robert Hawkes
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Patent number: 5898081Abstract: "One-pot" process for preparing methyl 2-(2-methylphenyl)-3-methoxypropenoate by the formylation and subsequent methylation of methyl o-tolylacetate in an aromatic hydrocarbon solvent in the presence of an alkali metal base and a phase transfer catalyst. The product of the process is useful as an intermediate in the manufacture of fungicides such as those described in EP 370629.Type: GrantFiled: February 9, 1995Date of Patent: April 27, 1999Assignee: Zeneca LimitedInventors: Alfred Glyn Williams, Nicholas Russell Foster
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Patent number: 5888934Abstract: A glyphosate composition comprises (I) N-phosphonomethylglycine or an agriculturally acceptable salt thereof, (ii) an alkyl polyglycoside surfactant, (iii) an ethoxylated alcohol, for example an ethoxylated alcohol obtained by ethoxylation of a linear or branched chain aliphatic mono alcohol having a chain length of from 8 to 20 carbon atoms and a mean degree of ethoxylation of from 2 to 50 moles of ethylene oxide per mole of alcohol, and optionally (iv) an additional surfactant, and optionally (v) a humectant.Type: GrantFiled: November 19, 1996Date of Patent: March 30, 1999Assignee: Zeneca LimitedInventors: Jane Karen Townson, Clifford Arthur Hart, Martin Keith Osborn, Michael John Bean
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Patent number: 5886231Abstract: A process for preparing a compound of formula (I): ##STR1## by rearrangement of a compound of formula (II): ##STR2## in a non-polar solvent in the presence of a cyanide source, an alkali or alkaline earth metal carbonate, a phase transfer catalyst and 1-6 moles of water with respect to the compound of formula (II).Type: GrantFiled: June 24, 1997Date of Patent: March 23, 1999Assignee: Zeneca LimitedInventors: Stephen Martin Brown, Howard Rawlinson
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Patent number: 5885569Abstract: A recombinant baculovirus for use as an insect control agent having a genome which comprises a polyhedrin gene and a heterologous gene, which expresses an insecticidal protein, wherein the polyhedrin gene and the heterologous gene are not under the control of the same promoter, and are located on the genome such that viral progeny produced by a recombination event with wild-type baculovirus which are viable do not retain expression of both the polyhedrin gene and the heterologous gene.Type: GrantFiled: September 24, 1996Date of Patent: March 23, 1999Assignee: Zeneca LimitedInventor: John David Windass
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Patent number: 5869740Abstract: Compounds of the formula: ##STR1## wherein R is CH.sub.2 X or CHX.sub.2 and X is chloro or bromo and R.sup.1 is chloro, bromo or nitro which are useful as intermediates for preparing herbicidal 2-(2'-substituted)-4'-(alkylsulfonyl)benzoyl-1,3-cyclohexanedione compounds.Type: GrantFiled: March 20, 1997Date of Patent: February 9, 1999Assignee: Zeneca LimitedInventors: Richard D. Gless, Jr., Nancy Kerlinger
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Patent number: 5866792Abstract: The chemically-inducible 27 kD subunit of the enzyme glutathione-S-transferase, isoform II (GST-II-27) and sequences encoding it are provided. In particular, a genomic DNA sequence encoding the gene promoter for the GST-II-27 subunit is provided. Then linked to an exogenous gene and introduced into a plant by transformation, and GST-II-27 promoter provides a means for the external regulation of expression of that exogenous gene. Transformation with DNA encoding glutathione-S-transferase polypeptides produces herbicide resistance transgenic plants.Type: GrantFiled: June 17, 1996Date of Patent: February 2, 1999Assignee: Zeneca LimitedInventors: Ian George Bridges, Simon William Jonathan Bright, Andrew James Greenland, David Charles Holt, Ian Jepson, Wolfgang Walter Schuch
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Patent number: 5863865Abstract: This invention relates to 4-benzoylisoxazoles of formula (I) ##STR1## as well as herbicide compositions containing them and their use as herbicides.Type: GrantFiled: October 28, 1997Date of Patent: January 26, 1999Assignee: Zeneca LimitedInventors: David L. Lee, Nigel Barnes
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Patent number: 5861480Abstract: Antimicrobial proteins capable of isolation from seeds of Aralia or Impatiens show a wide range of antifungal activity and some antibacterial activity. DNA encoding the proteins may be isolated and incorporated into vectors. Plants transformed with this DNA may be produced. The proteins find commerical application as antifungal or antibacterial agents; transformed plants will show increased disease-resistance. The invention further provides a method of expressing polyproteins in transgenic plants using DNA constructs based on the structure of the gene encoding the Impatiens antimicrobial proteins.Type: GrantFiled: August 19, 1996Date of Patent: January 19, 1999Assignee: Zeneca LimitedInventors: Shelia Attenborough, Willem Frans Broekaert, Rupert William Osborn, John Anthony Ray, Sarah Bronwen Rees, Ravindra Haribhai Tailor
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Patent number: 5856273Abstract: A compound of formula (I): ##STR1## where E is oxygen or sulphur; A is CR.sup.3 or N where R.sup.3 is hydrogen or hydrocarbyl; D completes a 5 or 6-membered non-aromatic heterocyclic ring which optionally contains additional heteroatoms selected from oxygen, nitrogen or sulphur and which is optionally substituted by an optionally substituted lower hydrocarbyl group, or an optionally substituted heteroaryl group; R.sup.1 and R.sup.2 are each independently hydrogen; optionally substituted lower hydrocarbyl, or optionally substituted heteroaryl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached, form a heterocyclic ring; Z represents halogen optionally substituted lower hydrocarbyl, optionally substituted lower hydocarbyloxy, optionally substituted lower hydrocarbylthio, hydrocarbylsulphinyl or hydrocarbylsulphonyl, cyano, nitro, CHO, NHOH, ONR.sup.7' R.sup.7", SF.sub.5 ; CO (optionally substituted lower hydrocarbyl), acylamino, COOR.sup.7, SO.sub.2 NR.sup.8 R.sup.9, CONR.sup.Type: GrantFiled: October 6, 1995Date of Patent: January 5, 1999Assignee: Zeneca LimitedInventors: Ian Trevor Kay, John Edward Duncan Barton, David John Collins, Bogdan Kowalczyk, Glynn Mitchell, John Martin Shribbs, John Micheal Cox, Nigel John Barnes, Stephen Christopher Smith
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Patent number: 5849754Abstract: The present invention concerns bicyclic amine derivatives of formula (I): ##STR1## wherein R.sup.1 is an optionally substituted 5-membered heterocyclic ring system containing from 1 to 3 heteroatoms individually selected from nitrogen, oxygen and sulfur atoms, and at least one unsaturation (double bond) between adjacent atoms in the ring, wherein the substutuents, if present, are selected from halogen atoms, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkenyl, alkylthio and alkyl amino groups, any of which groups contain up to eight carbon atoms, and wherein two substituents may join to form a fused ring; R.sup.2 represents hydrogen or cyano or a group selected from alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, alkoxycarbonyl, alkanesulfonyl, arenesulfonyl, alkenyloxycarbonyl, aralkyloxycarbonyl, aryloxycarbonyl, heterocyclylalkyl, carbamyl, dithiocarboxyl or XR.sup.3 (where X represents oxygen or a group NR.sup.4), provided that when R.sup.Type: GrantFiled: November 13, 1997Date of Patent: December 15, 1998Assignee: Zeneca LimitedInventors: Christopher John Urch, Terence Lewis, Raymond Leo Sunley
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Patent number: 5846767Abstract: A method for the expression of multiple proteins in a transgenic plant comprising inserting into the genome of the plant a gene construct comprising a 5'-region which includes a promoter which is capable of initiating transcription of a structural gene under the control thereof, a protein encoding sequence coding for more than one protein and a 3'-terminator region which includes a polyadenylation signal, each of the protein encoding sequences being separated from an adjacent protein encoding sequence by a DNA sequence which on translation provides a cleavage site whereby the expressed polyprotein is post-translationally processed into the component protein molecules. The DNA sequence which encodes the post-translation cleavage site may be derived from a virus, particularly a picornavirus. In a preferred embodiment the DNA sequence providing the cleavage site encodes the amino acid sequence NFDLLKLAGDVESNPGPFF.Type: GrantFiled: May 10, 1996Date of Patent: December 8, 1998Assignee: Zeneca LimitedInventors: Claire Halpin, Martin Denis Ryan
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Patent number: 5847138Abstract: A process for the preparing agrochemical intermediates of formula (I): ##STR1## wherein W is (CH.sub.3 O) CH.CHCO.sub.2 CH.sub.3 or CH.sub.3 O.CH.dbd.CCO.sub.2 CH.sub.3 ; Z.sup.1 is a halogen atom; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, acetoxy or acyl; the process comprising the steps of:(a) reacting a compound of formula (II): ##STR2## wherein X, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, with a compound of formula ROCH.sub.3, wherein R is a metal; and,(b) reacting the product of (a) with a compound of formula (III): ##STR3## wherein Z.sup.1 and Z.sup.2 are halogen atom. A process for the preparation of compounds of formula (II) and compounds of formula (II) themselves. A process for obtaining, in substantially pure form, a compound of formula (II) wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are all hydrogen.Type: GrantFiled: June 7, 1995Date of Patent: December 8, 1998Assignee: Imperial Chemical Industries PLCInventors: John David Jones, Gareth Andrew DeBoos, Paul Wilkinson, Brian Geoffrey Cox, Jan Michael Fielden