Abstract: An effective treatment for skin disorders characterized by abnormal skin cell behavior, including a pharmaceutically effective amount of Halofuginone. Skin disorders which can be treated include keloids, hypertrophic scars, psoriasis, acne, seborrhea and alopecia. Halofuginone can reduce or eliminate clinical symptoms of these disorders, as well as substantially prevent the formation of keloids and hypertrophic scars.

Abstract: A cutting insert has an upper surface bounded by a cutting edge, a base, and a peripheral flank surface. The shape of the peripheral flank surface varies along the height of the cutting insert. Near the top of the peripheral flank surface, it conforms to the round or polygonal geometry of the cutting edge so as to provide support for the cutting edge. Lower down the cutting insert, the peripheral flank surface is shaped to provide transverse bearing surfaces which have considerably lower pressure angles, i.e., resistance to turning moments, than would be provided by the inherent geometry of the cutting edge. Preferably, these transverse bearing surfaces are formed by recessed features such as channels, and most preferably, as chevron-type channels. This latter possibility leads to a lower cross-sectional geometry which approximates to an n-pointed star.