Patents Represented by Attorney, Agent or Law Firm Mark A. Hofer
  • Patent number: 4427779
    Abstract: Method for detecting circulating immune complexes containing endogenously bound Clq. Capillary tubes are filled with a mixture of Clq coated GPO reagent cells, rabbit anti-Clq antibodies, and precipitate from the biological fluid sample containing immune complexes. The mixture is allowed to react and the tubes read for the presence or absence of agglutination indicative of the absence or presence of said immune complexes respectively.
    Type: Grant
    Filed: May 26, 1982
    Date of Patent: January 24, 1984
    Assignee: Ortho Diagnostic Systems Inc.
    Inventors: Rudolph P. Reckel, Joanne L. Harris
  • Patent number: 4426357
    Abstract: A reagent kit for eluting antibodies present on the surface of red blood cells comprises sorbitan trioleate or other variants within the sorbitan family and a red blood cell diluent as well as methods for use.
    Type: Grant
    Filed: September 9, 1981
    Date of Patent: January 17, 1984
    Assignee: Ortho Diagnostic Systems Inc.
    Inventors: Sherry Buffington, Leonard T. Wilson
  • Patent number: 4420461
    Abstract: Kit for detecting circulating immune complexes containing endogenously bound Clq. Capillary tubes are filled with a mixture of Clq coated GPO reagent cells, rabbit anti-Clq antibodies, and precipitate from the biological fluid sample containing immune complexes. The mixture is allowed to react and the tubes read for the presence or absence of agglutination indicative of the absence or presence of said immune complexes respectively.
    Type: Grant
    Filed: May 26, 1982
    Date of Patent: December 13, 1983
    Assignee: Ortho Diagnostic Systems Inc.
    Inventors: Rudolph P. Reckel, Joanne L. Harris
  • Patent number: 4413632
    Abstract: A pulmonary monitor for measuring a complex set of variables utilizing a group of three pushbuttons arranged to operate in a hierarchical pattern for facilitating operator control of the functions of the monitor.
    Type: Grant
    Filed: October 9, 1979
    Date of Patent: November 8, 1983
    Assignee: Critikon, Inc.
    Inventors: Joseph E. Schlessinger, Richard G. Hamilton
  • Patent number: 4414197
    Abstract: Methods and apparatus wherein a very small number of sorted cells are attached to specified locations on a microscope slide circumscribed by well areas of a retainer slip. The cells are deposited in the wells and during centrifugation of the slide-retainer sandwich, are contacted with and attached to the serum albumin present in the well and coated on the slide. Removal of excess fluids, optional clamping means and the retainer slip followed by air drying provides for permanent attachment of rare, sorted cells in a localized, known area for subsequent staining, examination and analysis.
    Type: Grant
    Filed: March 19, 1982
    Date of Patent: November 8, 1983
    Assignee: Ortho Diagnostic Systems Inc.
    Inventor: Richard A. Dussault
  • Patent number: 4406653
    Abstract: Provided is a method as well as apparatus for a catheter catheter-balloon assembly wherein the catheter balloon is mounted on the catheter by means of adhesive and, in the preferred mode, an annular internal rib protrusion of the catheter balloon is provided for forming a sharply defined boundary of adhesive thereby aiding in the even and symmetrical inflation of the catheter balloon.
    Type: Grant
    Filed: January 26, 1982
    Date of Patent: September 27, 1983
    Assignee: Critikon, Inc.
    Inventor: Chris E. Nunez
  • Patent number: 4390484
    Abstract: Latex material disposed in a solvent is injected into a sheath fluid into which the solvent is soluble, but the latex is not. The solvent being jetted from a vibrating nozzle forms droplets within the flowing sheath, which is then delivered onto an inclined hydrophobic surface reposing at a low angle to the jet. As the droplet containing stream strikes and flows down the surface, its velocity is taken up as the phase separation process for forming microparticles begins.
    Type: Grant
    Filed: July 26, 1982
    Date of Patent: June 28, 1983
    Assignee: Ortho Diagnostics, Inc.
    Inventors: Igino Lombardo, Peter J. Natale
  • Patent number: 4379682
    Abstract: A core/sheath vibrating system is utilized to produce core droplets within the sheath, which in turn form into microparticles through phase separation. The flow momentum is first arrested by means of an inclined surface, and the combination is thence deposited, in a continuous, helical channel extending from one end to the other of the inside of a hollow, rotating drum. Rotation of the drum moves the forming microspheres through the channel. At the exit end of the drum, the sheath fluid which carries suspended microspheres, may be filtered, and the microspheres collected and utilized.
    Type: Grant
    Filed: April 29, 1981
    Date of Patent: April 12, 1983
    Assignee: Ortho Diagnostics, Inc.
    Inventors: Peter J. Natale, Igino Lombardo
  • Patent number: 4375347
    Abstract: Latex material disposed in a solvent is injected into a sheath fluid into which the solvent is soluble, but the latex is not. The solvent being jetted from a vibrating nozzle forms droplets within the flowing sheath, which is then delivered onto an inclined hydrophobic surface reposing at a low angle to the jet. As the droplet containing stream strikes and flows down the surface, its velocity is taken up as the phase separation process for forming microparticles begins.
    Type: Grant
    Filed: April 29, 1981
    Date of Patent: March 1, 1983
    Assignee: Ortho Diagnostics, Inc.
    Inventors: Igino Lombardo, Peter J. Natale
  • Patent number: 4336029
    Abstract: Methods and compositions for quantitating reticulocytes and platelets by fluorescence in a flow cytometer. The composition comprises an aqueous solution of the dye acridine orange, citrate ion, and para-formaldehyde at a pH of about 7.4 and an isotonic osmolality. The concentrations of the various ingredients are selected to maximized dye uptake by the reticulocytes and platelets to allow for the first time the fluorescent quantitation of these cells in whole blood using a flow cytometer.
    Type: Grant
    Filed: August 15, 1980
    Date of Patent: June 22, 1982
    Assignee: Ortho Diagnostic Systems Inc.
    Inventor: Peter J. Natale