Patents Represented by Attorney Mark C. Lang
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Patent number: 8329122Abstract: A method is presented for producing and isolating an isotopically enriched compound of a desired isotope from a parent radionuclide. The method includes forming, or placing, a precipitate containing a parent radionuclide of the desired daughter isotope in a first reaction zone and allowing sufficient time for the parent to decay into the desired gaseous daughter radioisotope. The method further contemplates collecting the desired daughter isotope as a solid in a second reaction zone through the application of temperatures below the freezing point of the desired isotope to a second reaction zone that is connected to the first reaction zone. Specifically, a method is presented for producing isotopically enriched compounds of xenon, including the radioactive isotope Xe-131m and the stable isotope Xe-131.Type: GrantFiled: July 1, 2009Date of Patent: December 11, 2012Assignee: The United States of America, as represented by the Department of EnergyInventor: Matthew G. Watrous
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Patent number: 8309333Abstract: AlkB from Pseudomonas putida was engineered using in-vivo directed evolution to hydroxylate small chain alkanes. Mutant AlkB-BMO1 hydroxylates propane and butane at the terminal carbon at a rate greater than the wild-type to form 1-propanol and 1-butanol, respectively. Mutant AlkB-BMO2 similarly hydroxylates propane and butane at the terminal carbon at a rate greater than the wild-type to form 1-propanol and 1-butanol, respectively. These biocatalysts are highly active for small chain alkane substrates and their regioselectivity is retained in whole-cell biotransformations.Type: GrantFiled: November 16, 2009Date of Patent: November 13, 2012Assignee: The United States of America, as represented by Department of EnergyInventors: Daniel J. Koch, Frances H. Arnold
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Patent number: 8293780Abstract: The present disclosure relates to novel compounds having the structural Formulas (1a,1b), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof as chemotherapy agents for treating of cancer, particularly androgen-independent prostate cancer. The disclosure also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.Type: GrantFiled: March 16, 2012Date of Patent: October 23, 2012Assignee: U.S. Department of EnergyInventors: Andrei A Gakh, Mykhaylo V. Vovk, Nina V. Mel'nychenko, Volodymyr A. Sukach
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Patent number: 8270554Abstract: Methods of producing cesium-131. The method comprises dissolving at least one non-irradiated barium source in water or a nitric acid solution to produce a barium target solution. The barium target solution is irradiated with neutron radiation to produce cesium-131, which is removed from the barium target solution. The cesium-131 is complexed with a calixarene compound to separate the cesium-131 from the barium target solution. A liquid:liquid extraction device or extraction column is used to separate the cesium-131 from the barium target solution.Type: GrantFiled: May 19, 2009Date of Patent: September 18, 2012Assignee: The United States of America, as represented by the United States Department of EnergyInventors: David H. Meikrantz, John R. Snyder
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Patent number: 8242284Abstract: The present disclosure relates to novel compounds having the structural Formulas (1a,1b), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof as chemotherapy agents for treating of cancer, particularly androgen-independent prostate cancer. The disclosure also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.Type: GrantFiled: August 24, 2010Date of Patent: August 14, 2012Assignee: The United States of America as represented by the United States Department of EnergyInventors: Andrei A. Gakh, Mykhaylo V. Vovk, Nina V. Mel'nychenko, Volodymyr A. Sukach
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Patent number: 8227105Abstract: The invention relates to a unique battery having a physicochemically active membrane separator/electrolyte-electrode monolith and method of making the same. The Applicant's invented battery employs a physicochemically active membrane separator/electrolyte-electrode that acts as a separator, electrolyte, and electrode, within the same monolithic structure. The chemical composition, physical arrangement of molecules, and physical geometry of the pores play a role in the sequestration and conduction of ions. In one preferred embodiment, ions are transported via the ion-hoping mechanism where the oxygens of the Al2O3 wall are available for positive ion coordination (i.e. Li+). This active membrane-electrode composite can be adjusted to a desired level of ion conductivity by manipulating the chemical composition and structure of the pore wall to either increase or decrease ion conduction.Type: GrantFiled: November 14, 2007Date of Patent: July 24, 2012Assignee: The United States of America as represented by the United States Department of EnergyInventors: Rex E. Gerald, II, Katarina J. Ruscic, Devin N. Sears, Luis J. Smith, Robert J. Klingler, Jerome W. Rathke
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Patent number: 8137700Abstract: Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.Type: GrantFiled: May 4, 2007Date of Patent: March 20, 2012Assignee: U.S. Department of EnergyInventors: Jean M. J. Frechet, Stephany M. Standley, Rachna Jain, Cameron C. Lee
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Patent number: 8119273Abstract: The invention relates to a unique battery having an active, porous membrane and method of making the same. More specifically the invention relates to a sealed battery system having a porous, metal oxide membrane with uniform, physicochemically functionalized ion channels capable of adjustable ionic interaction. The physicochemically-active porous membrane purports dual functions: an electronic insulator (separator) and a unidirectional ion-transporter (electrolyte). The electrochemical cell membrane is activated for the transport of ions by contiguous ion coordination sites on the interior two-dimensional surfaces of the trans-membrane unidirectional pores. The membrane material is designed to have physicochemical interaction with ions. Control of the extent of the interactions between the ions and the interior pore walls of the membrane and other materials, chemicals, or structures contained within the pores provides adjustability of the ionic conductivity of the membrane.Type: GrantFiled: March 23, 2007Date of Patent: February 21, 2012Assignee: The United States of America as represented by the Department of EnergyInventors: Rex E. Gerald, II, Katarina J. Ruscic, Devin N. Sears, Luis J. Smith, Robert J. Klingler, Jerome W. Rathke
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Patent number: 8110111Abstract: The present invention relates to a functionalized membrane contactor extraction/reaction system and method for extracting target species from multi-phase solutions utilizing ionic liquids. One preferred embodiment of the invented method and system relates to an extraction/reaction system wherein the ionic liquid extraction solutions act as both extraction solutions and reaction mediums, and allow simultaneous separation/reactions not possible with prior art technology.Type: GrantFiled: December 8, 2009Date of Patent: February 7, 2012Assignee: U.S. Department of EnergyInventors: Yupo J. Lin, Seth W. Snyder
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Patent number: 8071500Abstract: A catalyst for the oxidation of heavy metal contaminants, especially mercury (Hg), in an effluent stream is presented. The catalyst facilitates removal of mercury through the oxidation of elemental Hg into mercury (II) moieties. The active component of the catalyst is partially combusted coal, or “Thief” carbon, which can be pre-treated with a halogen. An untreated Thief carbon catalyst can be self-promoting in the presence of an effluent gas streams entrained with a halogen.Type: GrantFiled: July 13, 2010Date of Patent: December 6, 2011Assignee: The United States of America as represented by the United States Department of EnergyInventors: Evan J. Granite, Henry W. Pennline
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Patent number: 7887970Abstract: The instant invention relates a solid-state electrochemical cell and a novel separator/electrolyte incorporated therein. The invented electrochemical cell generally comprising: a unique metal oxyhydroxide based (i.e. AlOOH) separator/electrolyte membrane sandwiched between a first electrode and a second electrode. The novel separator/electrolyte comprises a nanoparticulate metal oxyhydroxide, preferably AlOOH and a salt which are mixed and then pressed together to form a monolithic metal oxyhydroxide-salt membrane.Type: GrantFiled: August 2, 2006Date of Patent: February 15, 2011Assignee: The United States of America as represented by the United States Department of EnergyInventors: Rex E. Gerald, II, Robert J. Klingler, Jerome W. Rathke
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Patent number: 7866201Abstract: A method and device for the measurement of dissolved gas within a fluid. The fluid, substantially a liquid, is pumped into a pipe. The flow of the fluid is temporally restricted, creating one or more low pressure regions. A measurement indicative of trapped air is taken before and after the restriction. The amount of dissolved air is calculated from the difference between the first and second measurements. Preferably measurements indicative of trapped air is obtained from one or more pressure transducers, capacitance transducers, or combinations thereof. In the alternative, other methods such as those utilizing x-rays or gamma rays may also be used to detect trapped air. Preferably, the fluid is a hydraulic fluid, whereby dissolved air in the fluid is detected.Type: GrantFiled: April 9, 2007Date of Patent: January 11, 2011Assignee: The United States of America as represented by the United States Department of EnergyInventor: Narinder Kumar Tutu
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Patent number: 7799225Abstract: The present invention relates to a membrane contactor assisted extraction system and method for extracting a single phase species from multi-phase working solutions. More specifically one preferred embodiment of the invention relates to a method and system for membrane contactor assisted water (MCAWE) extraction of hydrogen peroxide (H2O2) from a working solution.Type: GrantFiled: September 29, 2006Date of Patent: September 21, 2010Assignee: The United States of America as represented by the United States Department of EnergyInventors: Seth W. Snyder, Yupo J. Lin, Jamie A. Hestekin, Michael P. Henry, Peter Pujado, Anil Oroskar, Santi Kulprathipanja, Sarabjit Randhava
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Patent number: 7776780Abstract: Two new classes of catalysts for the removal of heavy metal contaminants, especially mercury (Hg) from effluent gases. Both of these classes of catalysts are excellent absorbers of HCl and Cl2 present in effluent gases. This adsorption of oxidizing agents aids in the oxidation of heavy metal contaminants. The catalysts remove mercury by oxidizing the Hg into mercury (II) moieties. For one class of catalysts, the active component is selected from the group consisting of iridium (Ir) and iridum-platinum (Ir/Pt) alloys. The Ir and Ir/Pt alloy catalysts are especially corrosion resistant. For the other class of catalyst, the active component is partially combusted coal or “Thief” carbon impregnated with Cl2. Untreated Thief carbon catalyst can be self-activating in the presence of effluent gas streams. The Thief carbon catalyst is disposable by means of capture from the effluent gas stream in a particulate collection device (PCD).Type: GrantFiled: July 14, 2005Date of Patent: August 17, 2010Assignee: The United States of America as represented by the United States Department of EnergyInventors: Evan J. Granite, Henry W. Pennline
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Patent number: 7651673Abstract: The present invention relates generally to the field of small scale pumping and, more specifically, to a method and system for very small scale pumping media through microtubes. One preferred embodiment of the invention generally comprises: method for small scale pumping, comprising the following steps: providing one or more media; providing one or more microtubes, the one or more tubes having a first end and a second end, wherein said first end of one or more tubes is in contact with the media; and creating surface waves on the tubes, wherein at least a portion of the media is pumped through the tube.Type: GrantFiled: May 18, 2009Date of Patent: January 26, 2010Assignee: The United States of America as represented by the United States Department of EnergyInventors: Zeke Insepov, Ahmed Hassanein
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Patent number: 7632384Abstract: The present invention relates to a multi-functional sensor system that simultaneously measures cathode and anode electrode potentials, dissolved ion (i.e. oxide) concentration, and temperatures in an electrochemical cell. One embodiment of the invented system generally comprises: a reference(saturated) electrode, a reference(sensing) electrode, and a data acquisition system. Thermocouples are built into the two reference electrodes to provide important temperature information.Type: GrantFiled: November 18, 2005Date of Patent: December 15, 2009Assignee: The United States of America as represented by the United States Department of EnergyInventors: Laszlo Redey, Karthick Gourishankar, Mark A. Williamson
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Patent number: 7632482Abstract: The present invention relates generally to the field of nanotechnology, carbon nanotubes and, more specifically, to a method and system for nano-pumping media through carbon nanotubes. One preferred embodiment of the invention generally comprises: method for nano-pumping, comprising the following steps: providing one or more media; providing one or more carbon nanotubes, the one or more nanotubes having a first end and a second end, wherein said first end of one or more nanotubes is in contact with the media; and creating surface waves on the carbon nanotubes, wherein at least a portion of the media is pumped through the nanotube.Type: GrantFiled: December 4, 2006Date of Patent: December 15, 2009Assignee: The United States of America as represented by the United States Department of EnergyInventors: Zeke Insepov, Ahmed Hassanein