Abstract: The present invention relates to antibacterial agents of the carbapenem class, in which the 2-position sidechain is characterized by a phenanthridine moiety typically having a substituent attached to the nitrogen of the phenanthridine and substituted at other positions by various neutral substituents. When there is substitution on the nitrogen of the phenathridine moiety that nitrogen is a charged quaternary nitrogen.
Type:
Grant
Filed:
January 27, 1993
Date of Patent:
August 9, 1994
Assignee:
Merck & Co., Inc.
Inventors:
Frank P. Dininno, Mark L. Greenlee, Thomas A. Rano, Wendy Lee