Patents Represented by Attorney Mark Daniel

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  • Antifungal macrolides and their synthesis
    Patent number: 5948770
    Abstract: There are disclosed novel antifungal macrolides of the formula ##STR1## compositions containing said compounds, methods of using said compounds and a method for synthesizing the compounds.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: September 7, 1999
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Bruno Tse
  • Reaction vessel filter for combinatorial chemistry or biological use
    Patent number: 5945070
    Abstract: A filter tube for a reaction or other fluid vessel is disclosed which maintains the vessel under an inert gas atmosphere and maintains the integrity of the inert gas seal while performing filtered or unfiltered filling or filtered draining operations.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: August 31, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Gary S. Kath, Gregory W. King
  • Cyclohexapeptidyl hydroxypropionitrile compounds
    Patent number: 5348940
    Abstract: Certain propionitrile compounds which have a cyclohexapeptidyl nucleus and which are found to have antibiotic activity with physical properties suitable for use in therapeutic compositions are described. A novel process for their preparation is also described.
    Type: Grant
    Filed: September 3, 1992
    Date of Patent: September 20, 1994
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Robert A. Zambias
  • Antifungal compound and compositions containing the compound
    Patent number: 5348970
    Abstract: A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: September 20, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Schwartz, Janet C. Onishi, Gerald F. Bills, Robert A. Giacobbe, Fernando Pelaez, Maria T. Diez, Francisca Vicente, Julian Gorrochategui, Gregory L. Helms, Barnali Pramanik
  • Microbial preparation of 13.beta.-13-deoxy-22,23-dihydro avermectin-B1A/B1B aglycone
    Patent number: 5225338
    Abstract: The known compound, 13.beta.-13-deoxy-22,23-dihydro-avermectin -B1a/B1b Aglycone is prepared microbiologically from cultures of the novel microorganisms (MA-6762, ATCC 55069, MA-6763 ATCC 55070) or the known microorganism Streptomyces lavendulae MA-6555 (ATCC 14159 or ATCC 55330). The compound is prepared by the biotransformation of 13-deoxy-22,23-dihydro avermectin B1a/B1b aglycone which oxidizes the 13-position and epimerizes the 13-position hydroxy group.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: July 6, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Kalinka Shumanov, Raymond F. White