Abstract: The present invention provides compounds which inhibit serine protease activity of matriptase or MTSP1. Also provided are pharmaceutical compositions comprising those compounds and methods of using the compounds and pharmaceutical compositions to treat conditions ameliorated by inhibition of matriptase or MTSP1.
Type:
Grant
Filed:
March 5, 2002
Date of Patent:
January 2, 2007
Inventors:
Joseph E. Semple, Gary S. Coombs, John E. Reiner, Edgar O Ong, Gian Luca Araldi