Patents Represented by Attorney Mark I. Bowditch

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  • Production of proteins by autoproteolytic cleavage
    Patent number: 7378512
    Abstract: The present invention relates to a process for the production of a heterologous polypeptide with homogeneous N-terminus in a bacterial host cell, wherein the heterologous polypeptide is autoproteolytically cleaved from an expressed fusion protein which comprises a polypeptide with the autoproteolytic activity of an autoprotease Npro of a pestivirus and the heterologous polypeptide by the Npro autoproteolytic activity.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: May 27, 2008
    Assignee: Biochemie Gesellschaft m.b.H
    Inventors: Tillmann Rumenapf, Heinz J Thiel, Jorg Windisch, Franz Knauseder