Patents Represented by Attorney Mark J. Buonauito

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  • Analogs of hirudin
    Patent number: 5837808
    Abstract: A tyrosine-substituted hirudin analog has antithrombogenic activity. Further simultaneous reaction at native tyrosine residues is prevented by mutation at those sites to encode nonreactive amino acids. Several novel strategies for coupling the hirudin analog to solid surfaces while simultaneously conserving antithrombogenic activity are disclosed.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: November 17, 1998
    Assignee: Baxter International Inc.
    Inventors: Cecilia S. L. Ku, Richard Johnson, Julian P. Breillatt, Jr.