Patents Represented by Attorney Mark R. Buscher

Find this attorney in the Justia Lawyer Directory

  • Zolpidem tablets
    Patent number: 8148393
    Abstract: A zolpidem tablet having modified release is designed as a tablet-in-tablet dosage form.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: April 3, 2012
    Assignee: Synthon BV
    Inventors: Frans van Dalen, Korinde Annemarie Jansen, Farid Abedin Dorkoosh
  • Process of making crystalline type II aripiprazole
    Patent number: 8093387
    Abstract: Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated solid-solid transformation, typically in ethyl acetate.
    Type: Grant
    Filed: December 24, 2009
    Date of Patent: January 10, 2012
    Assignee: Synthon BV
    Inventors: Gerrit J. B. Ettema, Raymond J. H. Westheim, Faysal Kalmoua
  • Process of making crystalline Type II aripiprazole
    Patent number: 7655798
    Abstract: Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated solid-solid transformation, typically in ethyl acetate.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: February 2, 2010
    Assignee: Synthon BV
    Inventors: Gerrit J. B. Ettema, Raymond J. H. Westheim, Faysal Kalmoua
  • Process for purification of anastrozole
    Patent number: 7655806
    Abstract: Anastrozole can be purified by crystallization from an aqueous-based solvent system. The aqueous-based solvent system can contain dilute acid, or an alcohol or both.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: February 2, 2010
    Assignee: Synthon BV
    Inventors: Jaroslav Pis, Rudolf Smrz
  • Process of making crystalline aripiprazole
    Patent number: 7642353
    Abstract: Crystalline aripiprazole Form B can be formed by crystallizing from a solvent selected from 1-propanol, 2-propanol, 1-butanol, ethyl acetate, acetonitrile or a combination thereof.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: January 5, 2010
    Assignee: Synthon BV
    Inventors: Gerrit Jan Ettema, Raymond Westheim, Faysal Kalmoua
  • Process for making montelukast and intermediates therefor
    Patent number: 7601741
    Abstract: The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formula and salts thereof. Further enhancements can be derived from certain intermediates, salts thereof and/or purification thereof before and/or after the reaction involving methylmagnesium halide.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: October 13, 2009
    Assignee: Synthon BV
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • Process for resolving citalopram
    Patent number: 7566793
    Abstract: The (S)-citalopram content of a mixture of (R)- and (S)-citalopram can be enriched by using L-tartaric acid as the resolving agent in the presence of formaldehyde.
    Type: Grant
    Filed: April 22, 2008
    Date of Patent: July 28, 2009
    Assignee: Synthon BV
    Inventor: Jie Zhu
  • Solid-state montelukast
    Patent number: 7553853
    Abstract: A solid form of a compound of formula 1: is provided. The compound of formula 1 can be obtained in solid state by precipitation from a solution containing the same. The compound is useful as leukotriene antagonist and can be formulated into a pharmaceutical composition that also includes a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: June 30, 2009
    Assignee: Synthon BV
    Inventors: Arjanne Overeem, Dennie J. M. van den Heuvel
  • Processes for making pioglitazone and compounds of the processes
    Patent number: 7541470
    Abstract: Pioglitazone can be made via a Darzens Condensation reaction in an industrially useful process.
    Type: Grant
    Filed: February 19, 2005
    Date of Patent: June 2, 2009
    Assignee: Synthon IP Inc.
    Inventors: Jie Zhu, Lambertus Thijs
  • Process for making aminoalkylphenyl carbamates and intermediates therefor
    Patent number: 7531684
    Abstract: A process for making aminoalkylphenyl carbamates, especially rivastigmine, can use less severe conditions using bis(p-nitrophenyl)carbonate (IX) as a phenol activator compound.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: May 12, 2009
    Assignee: Synthon BV
    Inventors: Henar Tejedor Vinent, Arjanne Overeem, Lambertus Thijs
  • Process for making montelukast and intermediates therefor
    Patent number: 7501517
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (4) is provided.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: March 10, 2009
    Assignee: Synthon IP, Inc.
    Inventors: Arjanne Overeem, Reinerus G. Gieling, Jie Zhu, Lambertus Thijs
  • Process for making desvenlafaxine
    Patent number: 7491848
    Abstract: Desvenlafaxine is formed from venlafaxine by the use of a demethylating agent comprising a metal sulfide, such as sodium sulfide, and optionally selenium.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: February 17, 2009
    Assignee: Synthon IP Inc.
    Inventors: Karel Pospisilik, Lambertus Thijs
  • Process for making montelukast and intermediates therefor
    Patent number: 7476748
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (11) is provided.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: January 13, 2009
    Assignee: Synthon BV
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • Stable salts of olanzapine
    Patent number: 7459449
    Abstract: Several salts of olanzapine, including olanzapine malonate, olanzapine glycolate, olanzapine maleate, and olanzapine benzoate, have been found to have favorable solid state characteristics.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: December 2, 2008
    Inventor: Rolf Keltjens
  • Montelukast amantadine salt
    Patent number: 7446116
    Abstract: An amantadine salt of montelukast is useful in purification of montelukast or its salts and as a pharmaceutical active ingredient.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: November 4, 2008
    Assignee: Synthon BV
    Inventors: Jiri Bartl, Frantisek Picha
  • Process for making risperidone and intermediates therefor
    Patent number: 7405298
    Abstract: The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: July 29, 2008
    Assignee: Synthon IP Inc.
    Inventors: Pavel Slanina, Jiri Bartl
  • Modified calcium phosphate excipient
    Patent number: 7364755
    Abstract: Calcium phosphate modified with a fatty acid wax in a weight ratio of 50:50 to 95:5, respectively, is useful as an excipient.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: April 29, 2008
    Assignee: Synthon IP Inc.
    Inventors: Joan Cucala Escoi, Montserrat Gallego Luengo, Arturo Siles Ortega
  • Pramipexole acid addition salts
    Patent number: 7365086
    Abstract: The benzene sulfonic acid salts of pramipexole have moderate water solubility and are useful pharmaceutical active agents.
    Type: Grant
    Filed: July 22, 2004
    Date of Patent: April 29, 2008
    Assignee: Synthon IP Inc.
    Inventors: Jacobus T. H. van Eupen, Frantisek Picha
  • Amlodipine free base
    Patent number: 7335380
    Abstract: Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline Form I or a novel Form II. Methods of making and using the amlodipine free base are set forth.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: February 26, 2008
    Assignee: Synthon IP Inc.
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker, Rolf Keltjens
  • Synthesis of olanzapine and intermediates thereof
    Patent number: 7329747
    Abstract: Olanzapine and salts thereof are made by a process that utilizes an N-formyl olanzapine intermediate of formula (4) or a salt thereof
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: February 12, 2008
    Assignee: Synthon IP Inc.
    Inventors: Rolf Keltjens, Theodorus H. A. Peters