Patents Represented by Attorney, Agent or Law Firm Mark R. Deniel
  • Inhibitors of prenyl-protein transferase
    Patent number: 6441017
    Abstract: The present invention is directed to macrocyclic compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemothera-peutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: August 27, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Ian M. Bell, Douglas C. Beshore, Steven N. Gallicchio, C. Blair Zartman