Abstract: Compounds of the formulas LAn-Z-X—WwD and BZ-X—WwD wherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide; X is an aminobenzyl ether self-immolative spacer group; W is an optional second self-immolative group; n is an integer of 0 or 1; and w is an integer of 0 or 1, and compositions of said compounds with pharmaceutically acceptable carrier, diluent and/or excipient, and methods of delivery the drug D via the compounds.

Abstract: A composite mixture of spherical objects and lubricant useful for its cushioning properties is disclosed and claimed. The composite mixture may be composed of microspheres typically less than 2000 microns in diameter with inert atmospheres sealed within their interiors and any of a variety of lubricants facilitating sliding and rolling movement between microspheres. Typically the composite mixture includes lubricant in a quantity sufficient to substantially coat the exterior surface of essentially all of the spherical objects, but in a quantity less than would cause dispersion of the spherical objects in the lubricant sufficient to physically separate the spherical objects from each other and substantially reduce the sliding and rolling contact of the spherical objects with each other. The preferred lubricant is a visco-elastic fluid that has a principle molecule and a cross-linking agent.

Abstract: Multi-adjustable wheelchair with adjustability features which accommodate the physical size and comfort of the wheelchair user is disclosed and claimed. The wheelchair includes (1) wheelchair frame width adjustment, (2) wheelchair rear axle position adjustment, (3) wheelchair seat height and bucketing angle adjustment, (4) wheelchair seat base width and length adjustment, (5) wheelchair seat back angle adjustment and (6) wheelchair seat fore and aft position adjustment. The wheelchair also includes a truss structure wheelchair wheel caster fork that is lightweight, attractive, strong, durable, and inexpensive to produce.

Abstract: A cushion that includes a base and numerous bladders locatable on the base is disclosed and claimed. Each bladder contains a quantity of filler insufficient to completely fill the bladder, and each bladder has a loose or elastomeric skin to accommodate its conforming to the shape of an object to be supported by the cushion. The top surface of each bladder acts as a hammock when supporting a cushioned object, and the bladders interact with each other to accommodate protuberance and crevices of the cushioned object. Other embodiments of the invention include a cushion that is pre-shaped in a form complementary to the shape of the object to be cushioned, and a cushion that re-shapes itself to maintain supporting forces that are generally equal across the contact surface of the supported object.

Abstract: A structure for frames for bicycles, wheelchairs, and other vehicles, as well as components thereof and other devices requiring a strong, lightweight frame shell. The preferred frame structure is constructed from plastic molded partial shells that are assembled into shells (such as tubing) that comprises the frame. The partial shells have protrusions and receptacles on the joining faces of their skins that are used to join the partial shells together to form the assembled shell. This results in a lightweight, durable and aesthetically pleasing frame. In an alternative embodiment, the partial shells have protrusions and receptacles within their interiors for additional strength. Additional attachment mechanisms such as screws, bolts, nails, clips or rivets may be used for reinforcement of the partial shells. A method for manufacturing the frame is also disclosed.