Patents Represented by Attorney Martha A. Cox

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  • Conversion of cephalosporin hydrohalide salt to alkali metal salt
    Patent number: 4937330
    Abstract: The present invention relates to processes for the preparation of alkali metal salts of amino acids. Preferably, the present invention relates to solid phase alkali metal salts of cephalosporins of formula III, wherein M is selected from the group consisting of sodium, potassium and lithium, characterized by birefringent lath- and rod-shaped particles, and processes for their manufacture.
    Type: Grant
    Filed: April 10, 1987
    Date of Patent: June 26, 1990
    Assignee: The Upjohn Company
    Inventors: Clifford E. Sacks, Loren H. Dill
  • Crystalline cephalosporin hydrohalide salts
    Patent number: 4902683
    Abstract: Crystalline hydrohalide salts of the cephalosporin antibiotic ceftiofur, processes for their manufacture, and pharmaceutical compositions containing one of these salts are provided.
    Type: Grant
    Filed: February 17, 1989
    Date of Patent: February 20, 1990
    Assignee: The Upjohn Company
    Inventors: Mahendra I. Amin, Jay A. Campbell
  • Substituted benzothiazoles, benzimidazoles, and benzoxazoles
    Patent number: 4873346
    Abstract: The present invention provides certain novel substituted benzothiazoles, benzimidazoles and benzoxazoles which are useful as inhibitors of leukotriene biosynthesis and/or as inhibitors of the action of lipoxygenase and/or as inhibitors of mucus secretion in mammalian metabolism. They are thus employed wherever it is medically necessary or desirable to inhibit these systems.
    Type: Grant
    Filed: September 20, 1985
    Date of Patent: October 10, 1989
    Assignee: The Upjohn Company
    Inventor: David J. Anderson
  • Cyclopentapyrazole and tetrahydroindazole compounds and their use as anti-inflammatory and anti-allergic agents
    Patent number: 4851425
    Abstract: The present invention provides novel compositions of matter and their therapeutic applications. More particularly, the present invention consists of novel cyclopentapyrazole and tetrahydroindazole compounds of formula XXX and their use as antiallergy agents, antiinflammatory agents or intermediates.
    Type: Grant
    Filed: February 3, 1987
    Date of Patent: July 25, 1989
    Assignee: The Upjohn Company
    Inventor: Herman W. Smith
  • 1,4-naphthalenediol and 1,4-hydroquinone derivatives
    Patent number: 4851586
    Abstract: Novel 1,4-naphthalenediol and 1,4-hydroquinone derivatives of formulas I, II, III and IV and their therapeutic uses as 5-lipoxygenase inhibitors, leukotriene inhibitors, antiinflammatory and/or inhibitors of mucus secretion agents are described. Also provided are novel intermediates useful for the preparation of said derivatives.
    Type: Grant
    Filed: May 18, 1987
    Date of Patent: July 25, 1989
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Chiu-Hong Lin
  • Intermediates for antiatherosclerotic furochromones
    Patent number: 4820851
    Abstract: The present invention particularly provides novel benzofuran compounds which are useful in the synthesis of khellin and antiatherosclerotic furochromones.
    Type: Grant
    Filed: July 14, 1986
    Date of Patent: April 11, 1989
    Assignee: The Upjohn Company
    Inventor: Ronald B. Gammill
  • Method for treating or preventing deep vein thrombosis using lipoxygenase inhibitors
    Patent number: 4791138
    Abstract: The present invention provides a novel methoda for preventing deep vein thrombosis comprising the administration of lipoxygenase inhibitors of Formula I ##STR1##
    Type: Grant
    Filed: June 25, 1986
    Date of Patent: December 13, 1988
    Assignee: The Upjohn Company
    Inventor: Robert G. Schaub
  • Intermediates for antiatherosclerotic furochromones
    Patent number: 4758676
    Abstract: The present invention provides novel compositions of matter and processes for their preparation. More particularly, the present invention consists of novel chemical intermediates and associated processes for the preparation of khellin and analogues thereof, which have demonstrated antiatherosclerotic activity.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: July 19, 1988
    Assignee: The Upjohn Company
    Inventor: Ayako Yamashita
  • Substituted naphthalenes, indoles, benzofurans, and benzothiophenes as lipoxygenase inhibitors
    Patent number: 4737519
    Abstract: The present invention provides certain novel substituted naphthalenes, indoles, benzofurans, and benzothiophenes of Formula I which are useful as inhibitors of leukotriene biosynthesis and as inhibitors of lipoxygenase. They are thus employed wherever it is medically necessary or desirable to inhibit these systems.
    Type: Grant
    Filed: June 25, 1986
    Date of Patent: April 12, 1988
    Assignee: The Upjohn Company
    Inventors: Ayako Yamashita, Herbert G. Johnson
  • Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert
    Patent number: 4705846
    Abstract: The present invention provides novel renin-inhibiting peptides of the formula X-A.sub.6 -B.sub.7 -C.sub.8 -D.sub.9 -E.sub.10 -F.sub.11 -G.sub.12 -H.sub.13 -I.sub.14 -Z, having a lactam pseudo-dipeptide at C.sub.8 -D.sub.9 positions, X and Z are terminal groups, and the remaining variables are absent or are amino acid residues. Such inhibitors are useful for the diagnosis and control of renin-dependent hypertension.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: November 10, 1987
    Assignee: The Upjohn Company
    Inventor: Suvit Thaisrivongs
  • 6-aryluracils and selected novel intermediates used in the preparation thereof
    Patent number: 4625028
    Abstract: This invention relates to selected hydrogenated 5,6-dihydro-6-aryluracils.
    Type: Grant
    Filed: July 11, 1983
    Date of Patent: November 25, 1986
    Assignee: The Upjohn Company
    Inventor: Herman W. Smith
  • Synthesis of precursors of anti-atherosclerotic furochromones
    Patent number: 4623737
    Abstract: The present invention provides novel compositions of matter and processes for their preparation. More particularly, the present invention consists of novel chemical intermediates and associated processes for the preparation of khellin and analogues thereof, which have demonstrated antiatherosclerotic activity.
    Type: Grant
    Filed: December 7, 1984
    Date of Patent: November 18, 1986
    Assignee: The Upjohn Company
    Inventor: Ayako Yamashita
  • Antiatherosclerotic furochromones and intermediates therefor
    Patent number: 4614809
    Abstract: The present invention particularly provides novel furochromones and intermediates for their preparation.
    Type: Grant
    Filed: April 25, 1984
    Date of Patent: September 30, 1986
    Assignee: The Upjohn Company
    Inventor: Ronald B. Gammill
  • Synthetic routes to benzofurans and benzothiophenes and intermediates therefor
    Patent number: 4609739
    Abstract: The present invention provides novel compositions of matter and processes for their preparation. More particularly, the present invention consists of novel chemical intermediates and associated processes for the preparation of khellin and other furochromone analogues, which have demonstrated antiatherosclerotic activity. These novel intermediates and processes can also be used for the preparation of benzofurans and benzothiophenes which inhibit the synthesis of leukotriene and/or lipoxygenase.
    Type: Grant
    Filed: November 6, 1984
    Date of Patent: September 2, 1986
    Assignee: The Upjohn Company
    Inventor: Ronald B. Gammill
  • Use of 6-aryluracils as antiinflammatory and antiarthritic agents
    Patent number: 4593030
    Abstract: This invention relates to the use of 6-aryluracils as antiinflammatory and antiarthritic agents and also to both novel intermediates and novel processes for the preparation of selected 6-aryluracils.
    Type: Grant
    Filed: September 17, 1984
    Date of Patent: June 3, 1986
    Assignee: The Upjohn Company
    Inventors: Harvey I. Skulnick, Herman W. Smith, Robert J. Smith, Wendell Wierenga
  • Processes for the preparation of 6-aryluracils
    Patent number: 4578466
    Abstract: This invention relates to the use of 6-aryluracils as antiinflammatory and antiarthritic agents and also to both novel intermediates and novel processes for the preparation of selected 6-aryluracils.
    Type: Grant
    Filed: September 17, 1984
    Date of Patent: March 25, 1986
    Assignee: The Upjohn Company
    Inventors: Harvey I. Skulnick, Herman W. Smith, Robert J. Smith, Wendell Wierenga
  • Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as leukotriene and lipoxygenase inhibitors and the novel 3-substituted compounds therein
    Patent number: 4576949
    Abstract: The present invention also provides novel compositions of matter. In particular, the present invention provides novel 3-substituted compounds of formula I which are from among the selected 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines having use as inhibitors of the synthesis of leukotrienes and as inhibitors of the action of lipoxygenase in mammalian metabolism.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: March 18, 1986
    Assignee: The Upjohn Company
    Inventor: Herman W. Smith
  • Antiatherosclerotic aminoethenyl furochromones
    Patent number: 4540798
    Abstract: The present invention provides certain novel aminoethanyl furochromones which are useful for antiatherosclerotic purposes.
    Type: Grant
    Filed: October 27, 1983
    Date of Patent: September 10, 1985
    Assignee: The Upjohn Company
    Inventor: Ronald B. Gammill
  • Furochromone intermediates
    Patent number: 4532340
    Abstract: The present invention provides novel intermediates used for preparation of anti-atherosclerotic furochromones.
    Type: Grant
    Filed: October 27, 1983
    Date of Patent: July 30, 1985
    Assignee: The Upjohn Company
    Inventor: Ronald B. Gammill