Patents Represented by Attorney Mary A. Apollina

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  • Process for the preparation of substituted-1,2,3,4-tetrahydroisoquinoline derivatives
    Patent number: 7872138
    Abstract: The present invention is directed to a process for the synthesis of substituted-1,2,3,4-tetrahydroisoquinoline derivatives, useful as intermediates in the synthesis of pharmaceutical agents.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: January 18, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Frank J. Villani, Hua Zhong
  • HIV protease inhibitors useful for the treatment of AIDS
    Patent number: 5747540
    Abstract: Compounds such as ##STR1## or pharmaceutically acceptable salts thereof, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Grant
    Filed: October 21, 1996
    Date of Patent: May 5, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Craig A. Coburn, Randall W. Hungate, Richard C. A. Isaacs, Joseph P. Vacca, Mary Beth Young