Patents Represented by Attorney, Agent or Law Firm Mary Ann Dillahunty
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Patent number: 5824340Abstract: The present invention is concerned with improving the delivery of a drug from a ruminal delivery device to give a consistent delivery of drug to the ruminal environment. Thus, the invention is directed to an improved ruminal drug delivery device comprising a semipermeable membrane having an exit orifice and defining a compartment, the compartment containing a swellable osmotic agent expandable driving member, a drug to be dispensed, a density element and, optionally, a partition layer between the osmotic expandable driving member and the drug formulation, wherein the improvement comprises an essentially gas-impermeable barrier means that separates the density element from the other components within the delivery device for isolating gases evolved from the density element from the other components within the delivery device. The barrier means further includes a coupling to transfer osmotic pressure to the semipermeable wall.Type: GrantFiled: November 5, 1996Date of Patent: October 20, 1998Assignee: ALZA CorporationInventors: Frederick H. Maruyama, Judy A. Magruder
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Patent number: 5795591Abstract: Osmotically driven drug delivery devices with walls of porous hydrophobic material as the sole diffusion-limiting wall component are disclosed. Despite pores which are considerably larger than the molecular dimensions of osmotically active species in the interior of the device, despite pores which by their hydrophobic character do not permit the passage of liquid water, and despite the absence of a cellulosic semi-permeable membrane, the devices absorb water by osmosis without loss of the osmotically active species, and function in a manner analogous to osmotic pumps of the prior art. By permitting the use of hydrophobic substances as the wall material, the invention permits the device to be constructed entirely from biodegradable materials.Type: GrantFiled: September 1, 1994Date of Patent: August 18, 1998Assignee: ALZA CorporationInventors: Eun Soo Lee, Scott A. Bura, Su Il Yum, Patrick S.-L. Wong, Felix Theeuwes
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Patent number: 5783213Abstract: The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks.Type: GrantFiled: March 6, 1997Date of Patent: July 21, 1998Assignee: ALZA CorporationInventors: David L. Rivera, Sonya Merrill, James B. Eckenhoff, Jeremy C. Wright, James L. Osborne
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Patent number: 5783205Abstract: The present invention is directed to a material which can be used to deliver a drug, such as an antibiotic, into a diseased tissue pocket, such as a periodontal pocket. The material is preferably a bioerodible oligomer or polymer. The oligomer or polymer containing the drug is heated and is then delivered, preferably by injection, into the tissue pocket at a physiologically compatible elevated temperature. Once the bioerodible material is injected into the pocket, the material cools to the body temperature of the pocket. As it cools, the material hardens and remains in place in the tissue pocket. The hardened material bioerodes in the pocket and releases the drug over a period of several days.Type: GrantFiled: April 10, 1997Date of Patent: July 21, 1998Assignee: ALZA CorporationInventors: Randall G. Berggren, David J. Enscore, Susan M. Marks, James L. Osborne, Patrick S.-L. Wong, Wouter E. Roorda
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Patent number: 5728396Abstract: The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.Type: GrantFiled: January 30, 1997Date of Patent: March 17, 1998Assignee: Alza CorporationInventors: John R. Peery, Keith E. Dionne, James B. Eckenhoff, Felix A. Landrau, Scott D. Lautenbach, Judy A. Magruder, Jeremy C. Wright
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Patent number: 5690952Abstract: A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. An exit passageway is provided for delivering the beneficial agent an interior compartment (18) to the animal. The exit passageway is sealed with a wax seal (30) which is expelled through the passageway (13) as the internal pressure within the device (10) reaches a predetermined "bursting" pressure.Type: GrantFiled: June 7, 1995Date of Patent: November 25, 1997Assignee: Judy A. Magruder et al.Inventors: Judy A. Magruder, James B. Eckenhoff, deceased, Richard Cortese, Jeremy C. Wright, John R. Peery, James B. Pike, Urano A. Robinson, Jonathan P. Smith, Lyle E. Ziemann
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Patent number: 5674895Abstract: A composition comprising oxybutynin and a device comprising oxybutynin are disclosed for oxybutynin therapy.Type: GrantFiled: May 22, 1995Date of Patent: October 7, 1997Assignee: Alza CorporationInventors: George V. Guittard, Francisco Jao, Susan M. Marks, David J. Kidney, Fernando Gumucio
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Patent number: 5667805Abstract: A composition comprising morphine; and a dosage form comprising morphine are disclosed for morphine therapy. A method of using the composition and the dosage form are disclosed and indicated for morphine therapy.Type: GrantFiled: October 4, 1996Date of Patent: September 16, 1997Assignee: Alza CorporationInventors: Sonya Merrill, Atul Devdatt Ayer, Paul Hwang, Anthony L. Kuczynski
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Patent number: 5660861Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises for maintaining the integrity of the dosage form and of the antiepileptic drug.Type: GrantFiled: May 12, 1995Date of Patent: August 26, 1997Assignee: ALZA CorporationInventors: Frank Jao, Patrick S.-L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
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Patent number: 5660847Abstract: An implantable dispenser is enclosed comprising a wall surrounding a compartment containing a first composition comprising a beneficial agent, an oil, a cosolvent and a polymer gellant, a second expandable composition, a third boundary maintaining composition between the first and second composition, and an exit port.Type: GrantFiled: November 8, 1994Date of Patent: August 26, 1997Assignee: ALZA CorporationInventors: Judy A. Magruder, James B. Eckenhoff, Jeremy C. Wright
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Patent number: 5650170Abstract: A drug delivery device is disclosed for delivering a drug to the intestine and the colon. The device comprises external means for delaying the delivery of drug in the stomach, and hydrophobic means for preventing the passage of fluid through the delay means.Type: GrantFiled: May 6, 1991Date of Patent: July 22, 1997Assignee: Alza CorporationInventors: Jeremy Corwin Wright, George V. Guittard
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Patent number: 5639477Abstract: The present invention is concerned with improving the delivery of a drug from a ruminal delivery device to give a consistent delivery of drug to the ruminal environment. Thus, the invention is directed to an improved ruminal drug delivery device comprising a semipermeable membrane having an exit orifice and defining a compartment, the compartment containing a swellable osmotic agent expandable driving member, a drug to be dispensed, a density element and, optionally, a partition layer between the osmotic expandable driving member and the drug formulation, wherein the improvement comprises an essentially gas-impermeable barrier means that separates the density element from the other components within the delivery device for isolating gases evolved from the density element from the other components within the delivery device. The barrier means further includes a coupling to transfer osmotic pressure to the semipermeable wall.Type: GrantFiled: June 7, 1995Date of Patent: June 17, 1997Assignee: ALZA CorporationInventors: Frederick H. Maruyama, Judy A. Magruder
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Patent number: 5633011Abstract: A hormone replacement composition, a hormone replacement dosage form, and a method of hormone replacement are disclosed and indicated for the management of hormone replacement therapy.Type: GrantFiled: August 4, 1994Date of Patent: May 27, 1997Assignee: ALZA CorporationInventors: Liang C. Dong, Patrick S.-L. Wong, Steven Espinal
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Patent number: 5630808Abstract: A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.Type: GrantFiled: March 1, 1994Date of Patent: May 20, 1997Assignee: ALZA CorporationInventors: Judy A. Magruder, James B. Eckenhoff, Richard Cortese, Jeremy C. Wright, John R. Peery
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Patent number: 5620700Abstract: The present invention is directed to a material which can be used to deliver a drug, such as an antibiotic, into a diseased tissue pocket, such as a periodontal pocket. The material is preferably a bioerodible oligomer or polymer. The oligomer or polymer containing the drug is heated and is then delivered, preferably by injection, into the tissue pocket at a physiologically compatible elevated temperature. Once the bioerodible material is injected into the pocket, the material cools to the body temperature of the pocket. As it cools, the material hardens and remains in place in the tissue pocket. The hardened material bioerodes in the pocket and releases the drug over a period of several days.Type: GrantFiled: May 9, 1995Date of Patent: April 15, 1997Assignee: ALZA CorporationInventors: Randall G. Berggren, David J. Enscore, Susan M. Marks, James L. Osborne, Patrick S.-L. Wong, Wouter E. Roorda
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Patent number: 5620705Abstract: A hormone replacement composition, a hormone replacement dosage form, and a method of hormone replacement are disclosed and indicated for the management of hormone replacement therapy.Type: GrantFiled: May 16, 1995Date of Patent: April 15, 1997Assignee: ALZA CorporationInventors: Liang C. Dong, Patrick S.-L. Wong, Steven Espinal
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Patent number: 5614578Abstract: A dosage form is disclosed comprising an injection-molded housing member free of organic solvents.Type: GrantFiled: October 28, 1994Date of Patent: March 25, 1997Assignee: Alza CorporationInventors: Liang C. Dong, Patrick S. L. Wong, Crystal Pollock, Vincent J. Ferrari
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Patent number: 5609885Abstract: The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks.Type: GrantFiled: February 10, 1995Date of Patent: March 11, 1997Assignee: ALZA CorporationInventors: David L. Rivera, Sonya Merrill, James B. Eckenhoff, Jeremy C. Wright, James L. Osborne
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Patent number: 5607696Abstract: The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks.Type: GrantFiled: May 16, 1995Date of Patent: March 4, 1997Assignee: Alza CorporationInventors: David L. Rivera, Sonya Merrill, James B. Eckenhoff, Jeremy C. Wright, James L. Osborne
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Patent number: RE35601Abstract: The present invention is directed to an improved fluid-imbibing dispensing device for delivering a beneficial agent to a biological environment of use, the dispensing device being of the type having a housing which includes a fluid-impermeable first wall section with an open end and a fluid-permeable second wall section with an open end, an internal compartment formed by the first and second wall sections, exit means in the housing, a beneficial agent in that portion of the compartment formed by the first wall section, expandable driving means in that portion of the compartment formed by the second wall section, and a partition layer between the beneficial agent and the expandable driving means; wherein the improvement comprises the first wall section being comprised of an extremely fluid-impermeable material and the open end of each of the first wall section and the second wall section having reciprocally tapered edges one with the other to form a tapered lap joint for mating engagement, the tapered lap joinType: GrantFiled: August 11, 1994Date of Patent: September 2, 1997Assignee: ALZA CorporationInventor: James B. Eckenhoff, deceased