Patents Represented by Attorney Mary Anne Schofield
  • Patent number: 5359032
    Abstract: This invention relates to interleukin inhibitors (IL-1 INHs) that selectively inhibit interleukin 1 activity. The invention also relates to processes for purifying such IL-1 INHs from urine and for producing such IL-1 INHs by hosts transformed with recombinant DNA molecules comprising DNA sequences encoding the inhibitors, and to methods of treatment and compositions characterized by such IL-1 INHs. These methods and agents are useful in immunosuppressive and anti-inflammatory applications and therapies.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: October 25, 1994
    Assignee: Biogen Inc.
    Inventors: Jean M. Dayer, Philippe L. Seckinger, Gonzalo J. Mazzei, Alan R. Shaw
  • Patent number: 5350571
    Abstract: Improved emulsions of highly fluorinated organic compounds. The emulsions comprise a highly fluorinated organic compound, an oil, that is not substantially surface active and not significantly water soluble, and a surfactant. They are characterized by a well-defined relationship in the relative amounts of the three components.
    Type: Grant
    Filed: February 24, 1992
    Date of Patent: September 27, 1994
    Assignee: HemaGen/PFC
    Inventors: Robert J. Kaufman, Thomas J. Richard
  • Patent number: 5346990
    Abstract: A method of sorting living cells based on DNA content. Mammalian sperm subpopulations enriched in X- or Y-sperm. X- and Y-enriched sperm-plasma-membrane vesicles. Substantially pure sex-associated membrane (SAM) proteins. Antibodies binding to X-or Y-SAM proteins, essentially free of antibodies binding to Y- or X-SAM proteins respectively, or to the H-Y antigen. Semen samples enriched for X- or Y-sperm. Methods for increasing the probability that offspring will be male or female comprising the step of allowing as penn from an enriched semen sample to fertilize an ovum. Methods for increasing the probability that offspring will be male or female comprising the step of immunizing a female with X- or Y-SAM proteins. Methods of decreasing fertility comprising the step of immunizing a female with both X- and Y-sperm. Methods of increasing the probability that mammalian offspring will carry a gene for a particular sex-chromosome linked trait.
    Type: Grant
    Filed: March 12, 1991
    Date of Patent: September 13, 1994
    Assignee: Cytogam, Inc.
    Inventor: Glenn F. Spaulding