Abstract: Methods of synthesizing starch acetate containing at least 20% high molecular weight carbohydrates using a MSA catalyst alone, or in combination with a co-catalyst promoting cross-linking, such a phosphoric acid, are described. The MSA is desirably added slowly following beginning of the exothermic reaction of starch, acetic acid and acetic anhydride.
Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
Abstract: High yields of active Factor IX are produced by culturing a CHO cell line transfected with chromosomally-integrated Factor IX cDNA in medium to which vitamin K is added.
Type:
Grant
Filed:
May 5, 1986
Date of Patent:
September 13, 1988
Assignee:
Genetics Institute, Inc.
Inventors:
Randal J. Kaufman, Charles B. Shoemaker, Louise C. Wasley