Abstract: Monoclonal antibodies and fragments thereof, with binding specificity for an epitope on the carboxy terminus of prothrombin activation peptide F1.2, which can be used in immunoassays to predict thrombosis by measuring the extent of activation of prothrombin. These monoclonal antibodies are also included in a kit for performing such immunoassays.
Type:
Grant
Filed:
December 30, 1993
Date of Patent:
November 3, 1998
Assignee:
Akzo Nobel N.V.
Inventors:
Marcie J. Hursting, Bryan T. Butman, Jerald P. Steiner, Bryant M. Moore, Frederick A. Dombrose