Patents Represented by Attorney, Agent or Law Firm Mary E. McCarthy
  • Substituted histidines
    Patent number: 5565480
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: October 15, 1996
    Assignee: SmithKline Beecham Corporation
    Inventors: John G. Gleason, Judith Hempel, David T. Hill, James Samanen, Joseph Weinstock
  • Method of antagonizing angiotensin II receptors in mammals using substituted [1H-Imidazol-5-YL] alkenoic acids
    Patent number: 5530017
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: June 25, 1996
    Assignee: SmithKline Beecham Corp
    Inventors: Gerald R. Girard, Judith Hempel, David T. Hill, James Samanen, Joseph Weinstock
  • N-(heteroaryl) imidazolyl-alkenoic acids having angiotension II receptor antagonist activity
    Patent number: 5447949
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: November 15, 1993
    Date of Patent: September 5, 1995
    Assignee: SmithKline Beecham Corporation
    Inventors: Gerald R. Girard, David T. Hill, Joseph Weinstock
  • Substituted histidines having angiotension II receptor antagonist activity
    Patent number: 5444081
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: February 19, 1993
    Date of Patent: August 22, 1995
    Assignee: SmithKline Beecham Corp
    Inventors: John G. Gleason, Judith Hempel, David T. Hill, James Samanen, Joseph Weinstock
  • Substituted [1H-imidazol-5-ylialkanoic acids having angiotension II receptor antagonist activity
    Patent number: 5444080
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: January 29, 1993
    Date of Patent: August 22, 1995
    Assignee: SmithKline Beecham Corporation
    Inventors: Gerald R. Girard, Judith Hampel, David T. Hill, James Samanen, Joseph Weinstock
  • Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
    Patent number: 5418250
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: May 23, 1995
    Assignee: SmithKline Beecham Corporation
    Inventors: Joseph A. Finkelstein, Richard M. Keenan, Joseph Weinstock
  • Imidazolyl-alkenoic acids
    Patent number: 5395847
    Abstract: Angiotensin II receptor antagonists having tile formula: ##STR1## or a pharmaceutically acceptable salt thereof which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals. These antagonists function as prodrugs in vivo.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: March 7, 1995
    Assignee: SmithKline Beecham Corporation
    Inventors: Joseph Weinstock, Dimitri E. Gaitanopoulos
  • Medicament
    Patent number: 5387601
    Abstract: The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for the primary and secondary prevention of infarction.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: February 7, 1995
    Assignee: SmithKline Beecham p.l.c.
    Inventor: James Hill
  • Process
    Patent number: 5336781
    Abstract: There is disclosed a process for the preparation of a compound of structure (I) ##STR1## in which n is 1 to 3 and each group R is hydrogen or C.sub.1-4 alkyl, which comprises, reaction of compound of structure (II) ##STR2## (prepared by esterifying the hydroxyl compound) in which R.sup.1 is C.sub.1-4 alkyl, phenyl or substituted phenyl and n is 1 to 3, with an amine HNR.sub.2 in which R is as described for structure (I), and optionally thereafter forming a salt. Intermediates are also disclosed.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: August 9, 1994
    Assignee: SmithKline & French Laboratories Limited
    Inventors: Robert Giles, Timothy C. Walsgrove
  • Medicaments
    Patent number: 5326781
    Abstract: Benzylimidazole derivatives are described as anxiolytic agents.
    Type: Grant
    Filed: January 8, 1993
    Date of Patent: July 5, 1994
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Ann J. Hunter, Rodney C. Young, Lars M. Wood
  • Substituted imidazoles having angiotensin II receptor blocking activity
    Patent number: 5312828
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: August 14, 1991
    Date of Patent: May 17, 1994
    Inventors: Joseph A. Finkelstein, Richard M. Keenan, Joseph Weinstock
  • Substituted benzimidazoles useful as angiotension II receptor antagonists
    Patent number: 5294631
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: October 13, 1992
    Date of Patent: March 15, 1994
    Assignee: SmithKline Beecham Corporation
    Inventors: Robert G. Franz, Joseph Weinstock
  • Substituted N-(imidazolyl)alkyl alanine derivatives
    Patent number: 5248689
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: September 28, 1993
    Assignee: SmithKline Beecham Corporation
    Inventors: Gerald R. Girard, David T. Hill, Joseph Weinstock
  • Thiadiazinones for stimulating cardiac activity
    Patent number: 5246928
    Abstract: This invention relates to N-phenylpyridone derivatives which have inotropic, vasodilator and bronchodilator activity. A compound of the invention is 5-methyl-6-[4-(4-oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)pyri dazinone.
    Type: Grant
    Filed: July 10, 1991
    Date of Patent: September 21, 1993
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Substituted 5-(alkyl)carboxamide imidazoles
    Patent number: 5234917
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: November 30, 1990
    Date of Patent: August 10, 1993
    Inventors: Joseph A. Finkelstein, Judith Hempel, Richard M. Keenan, James Samanen, Joseph Weinstock
  • Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
    Patent number: 5185351
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: August 14, 1991
    Date of Patent: February 9, 1993
    Assignee: SmithKline Beecham Corporation
    Inventors: Joseph A. Finkelstein, Richard M. Keenan, Joseph Weinstock
  • Substituted 5-((tetrazolyl)alkenyl)imidazoles and pharmaceutical methods of use thereof
    Patent number: 5177096
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: January 5, 1993
    Assignee: SmithKline Beecham Corporation
    Inventors: Richard M. Keenan, Joseph Weinstock
  • Chemical compounds
    Patent number: 5066653
    Abstract: Phosphodiesterase (type III) inhibitors having the formula: ##STR1## wherein R.sup.4 is hydrogen and A is a dihydro-1,2,4-triazin-3-one group or a dihydro-1,2,4-triazin-6-one group which are useful in stimulating cardiac activity and in treating congestive heart failure and bronchoconstriction, pharmaceutical compositions including these inhibitors, and methods of using these compounds to produce phosphodiesterase (type III) inhibition in mammals.
    Type: Grant
    Filed: December 18, 1989
    Date of Patent: November 19, 1991
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • .alpha.-adrenergic receptor antagonists and methods of use thereas
    Patent number: 5006521
    Abstract: Alpha-adrenoceptor antagonists having the formula: ##STR1## which are useful to produce .alpha.-adrenoceptor antagonism, pharmaceutical compositions including these antagonists, and methods of using these antagonists to produce .alpha.-adrenoceptor antagonism in mammals.
    Type: Grant
    Filed: March 13, 1990
    Date of Patent: April 9, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: John J. Lafferty, Robert M. DeMarinis, Dinubhai H. Shah
  • Dopamine-.beta.-hydroxylase inhibitors
    Patent number: 4992459
    Abstract: Potent DBH inhibitors having the formula ##STR1## can be used to inhibit DBH activity in mammals.
    Type: Grant
    Filed: May 18, 1988
    Date of Patent: February 12, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Joseph A. Finkelstein, James S. Frazee, Carl Kaiser, Lawrence I. Kruse, Thomas B. Leonard