Abstract: The present invention relates to modified amino acids of general formula
wherein
A, Z, X, n, m, R, R2, R3, R4 and R11 are defined as in claims 1 to 5, their tautomers, their diastereomers, their enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them as well as their use for the production and purification of antibodies and as labelled compounds in RIA- and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.
Type:
Grant
Filed:
October 12, 1999
Date of Patent:
February 5, 2002
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Helmut Pieper, Henri Doods, Gerhard Hallermayer, Michael Entzeroth, Wolfgang Wienen
Abstract: Racemates, diastereoisomers and optical isomers of a compound of formula (I):
wherein
B is H, a C6 or C10 aryl, C7-16 aralkyl; Het or (lower alkyl)-Het, all of which optionally substituted with C1-6 alkyl; C1-6 alkoxy; C1-6 alkanoyl; hydroxy; hydroxyalkyl; halo; haloalkyl; nitro; cyano; cyanoalkyl; amino optionally substituted with C1-6 alkyl; amido; or (lower alkyl)amide; or
B is an acyl derivative of formula R4—C(O)—; a carboxyl of formula R4—O—C(O)—; an amide of formula R4—N(R5)—C(O)—; a thioamide of formula R4—N(R5)—C(S)—; or a sulfonyl of formula R4—SO2; R5 is H or C1-6 alkyl; and
Y is H or C1-6 alkyl;
R3 is C1-8 alkyl, C3-7 cycloalkyl, or C4-10 alkylcycloalkyl, all optionally substituted with hydroxy, C1-6 alkoxy, C1-6 thioalkyl, amido, (lower alkyl)amido, C6 or C10 aryl, or C7-16 aralkyl;
R2 is CH2—R20, NH—R20, O—R20 or S—R20, wherein R20 is a saturated or unsaturated C3-7 cycloalkyl o
Type:
Grant
Filed:
September 29, 2000
Date of Patent:
December 11, 2001
Assignee:
Boehringer Ingelheim (Canada) Ltd.
Inventors:
Montse Llinas-Brunet, Murray D. Bailey, Dale R. Cameron, Elise Ghiro, Nathalie Goudreau, Marc-Andre Poupart, Jean Rancourt, Youla S. Tsantrizos, Anne-Marie Faucher, Teddy Halmos, Dominik M. Wernic
Abstract: Racemates, diastereolsomers and optical isomers of a compound of formula (I):
wherein B is H, a C6 or C10 aryl, C7-16 aralkyl; Het or (lower alkyl)-Het, all of which optionally substituted with C1-6 alkyl; C1-6 alkoxy; C1-6 alkanoyl; hydroxy; hydroxyalkyl; halo; haloalkyl; nitro; cyano; cyanoalkyl; amino optionally substituted with C1-6 alkyl; amido; or (lower alkyl)amide; or
B is an acyl derivative of formula R4—C(O)—; a carboxyl of formula R4—O—C(O)—; an amide of formula R4—N(R5)—C(O)—; a thioamide of formula R4—N(R5)—C(S)—; or a sulfonyl of formula R4—SO2; R5 is H or C1-6 alkyl; and
Y is H or C1-6 alkyl;
R3 is C1-8 alkyl, C3-7 cycloalkyl, or C4-10 alkylcycloalkyl, all optionally substituted with hydroxy, C1-6 alkoxy, C1-6 thioalkyl, amido, (lower alkyl)amido, C6 or C10 aryl, or C7-16 aralkyl;
R2 is CH2—R20, NH—R20, O—R20 or S—R20, wherein R20 is a saturated or unsaturated C3-7 cycloalkyl or
Type:
Grant
Filed:
November 1, 2000
Date of Patent:
December 11, 2001
Assignee:
Boehringer Ingelheim (Canada) Ltd.
Inventors:
Montse Llinas-Brunet, Murray D. Bailey, Dale R. Cameron, Elise Ghiro, Nathalie Goudreau, Marc-Andre Poupart, Jean Rancourt, Youla S. Tsantrizos, Anne-Marie Faucher, Teddy Halmos, Dominik M. Wernic
Abstract: The invention provides compounds of the formula 1 that are active against the HSV primase enzyme:
wherein
R1 is hydroxy or amino;
R2 is hydrogen, halo, (C1-4)alkyl or (C1-4)alkoxy; R3 is hydrogen, halo, (C1-4)alkyl, (C1-4)alkoxy, amino or azido; R4 has the same significance as R2;
R5 is hydrogen or (C1-4)alkyl; and R is (C1-7)alkyl, (C3-6)cycloalkyl, {phenyl(C1-7)alkyl}, {phenyl(C1-7)alkoxy}, {{(monocyclic heterocyclo)-{(C1-7)alkoxy}}, CH(W)C(O){O-(C1-4)alkyl} wherein W is hydrogen or (C1-7)alkyl, or
wherein Y is hydrogen or (C1-7)alkyl, and Z is (C1-7)alkyl, (C3-6) cycloalkyl, {(C3-6)cycloalkyl}- {(C1-7)alkyl}, phenyl(C1-7)alkyl or {{(monocyclic heterocyclo)-{(C1-7)alkyl}}, or Y and Z together with the nitrogen atom to which they are attached represent, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl or 1-(4-methylpiperazinyl); with the provisos that (1) when R is CH(W
Type:
Grant
Filed:
March 24, 2000
Date of Patent:
November 27, 2001
Assignee:
Boehringer Ingelheim (Canada) Ltd.
Inventors:
Bruno Simoneau, Michele Liuzzi, Anton Mentrup
Abstract: A racemate, diastereoisomer and optical isomer of a compound of formula (I):
wherein B is H, a C6 or C10 aryl, C7-16 aralkyl; Het or (lower alkyl)-Het, all of which may be optionally substituted with C1-6 alkyl; C1-6 alkoxy; C1-6 alkanoyl; hydroxy; hydroxyalkyl; halo; haloalkyl; nitro; cyano; cyanoalkyl; amino optionally substituted with C1-6 alkyl; amido; or (lower alkyl)amide; or
B is an acyl derivative of formula R4—C(O)—; a carboxyl derivative of formula R4—O—C(O)—; an amide derivative of formula R4—N(R5)—C(O)—; a thioamide derivative of formula R4—N(R5)—C(S)—; or a sulfonyl of formula R4—SO2; R5 is H or C1-6 alkyl; and
Y is H or C1-6 alkyl;
R3 is C1-8 alkyl, C3-7 cycloalkyl, or C4-10 alkylcycloalkyl, all optionally substituted with hydroxy, C1-6 alkoxy, C1-6 thioalkyl, amido, (lower alkyl)amido, C6 or C10 aryl, or C7-16 aralkyl;
R2 is CH2—R20, NH—R20, O—R20 or S—R20, wherein R20 is a satu
Type:
Grant
Filed:
August 5, 1999
Date of Patent:
November 27, 2001
Assignee:
Boehringer Ingelheim (Canada) Ltd
Inventors:
Montse Llinas-Brunet, Murray D. Bailey, Dale Cameron, Elise Ghiro, Nathalie Goudreau, Marc-André Poupart, Jean Rancourt, Youla S. Tsantrizos, Anne-Marie Faucher, Teddy Halmos, Dominik M. Wernic, Bruno Simoneau
Abstract: Substituted indolinones of general formula
having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. Exemplary compounds are:
3-Z-[1-(4-(N-Benzyl-N-methyl-aminomethyl)-phenylamino)-1-methyl-methylene]-5-amido-2-indolinone and
3-Z-[1-(4-(2,3,4,5-Tetrahydro-benzo(d)azepin-3-yl-methyl)-phenylamino)-1-methyl-methylene]-5-amido-2-indolinone.
Type:
Grant
Filed:
June 1, 1999
Date of Patent:
November 20, 2001
Assignee:
Boehringer Ingelheim Pharma KG
Inventors:
Armin Heckel, Rainer Walter, Wolfgang Grell, Jacobus C. A. van Meel, Norbert Redemann
Abstract: The present invention relates to a method for isolating cloned papillomavirus E1 protein from a eukaryotic expression system having demonstrable and reproducible viral helicase activity and preparation containing essentially pure E1 protein. The invention further relates to the use of this novel E1 protein preparation in a screening assay for identifying antiviral agents. More particularly a high throughput assay to screen for agents capable of inhibiting HPV DNA replication. The assay is based on measuring the effect of antiviral agents on the activity of the E1 protein and more specifically on its helicase activity.
Abstract: On account of the surprisingly powerful and long-lasting effect thereof, the salts of the L-(−)-enantiomer of (endo, syn)-(−)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(methylethyl)-8-azoniabicyclo [3,2,1]octane are suitable as active substances for drugs administered by inhalation for respiratory tract therapy.
Type:
Grant
Filed:
August 6, 1999
Date of Patent:
October 9, 2001
Assignee:
Boehringer Ingelheim KG
Inventors:
Rolf Banholzer, Richard Reichl, Bernd Disse, Georg Speck
Abstract: Methods for removing soluble material from confined spaces within substrates such as containers, capsules and porous powders comprising extraction with supercritical fluids, the pressure of which is preferably modulated between an upper level and a lower level within a relatively narrow range of fluid pressure and density. The method permits enhanced extraction efficiency, catalytic reaction rates and ability to maintain catalyst activity.
Type:
Grant
Filed:
March 3, 2000
Date of Patent:
September 25, 2001
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
Abstract: A compound of formula (I) is disclosed:
wherein X, z, W, Y, R1 through R5, m and n are as define herein. These compounds are peptidomimetic inhibitors of human cytomegalovirus (HCMV) protease and are useful for the treatment of human cytomegalovirus infection.
Type:
Grant
Filed:
October 19, 1998
Date of Patent:
September 18, 2001
Assignee:
Boehringer Ingelheim Ltd.
Inventors:
Murray D. Bailey, Gulrez Fazal, Pierre Lavallee, William Ogilvie, Marc-Andre Poupart
Abstract: The invention relates to oxadiazole derivatives of general formula (I)
wherein X, Y, Z and R1 are defined as described in the specification and claims, processes for preparing them and their use as pharmaceutical compositions.
Type:
Grant
Filed:
July 26, 1999
Date of Patent:
August 21, 2001
Assignee:
Boehringer Ingelheim KG
Inventors:
Michael Brenner, Roland Maier, Marion Wienrich, Thomas Weiser, Rainer Palluk, Wolf-Dietrich Bechtel, Angelo Sagrada, Helmut Ensinger, Uwe Pschorn, Raffaele Cesana
Abstract: An enantiomeric-resolving process for obtaining (1R,2S)-1-amino-2-vinylcyclopropyl carboxylic acid methyl ester by use of an esterase, and especially Alcalase®, is disclosed.
Abstract: An aqueous pharmaceutical suspension consisting essentially of nevirapine hemihydrate having a particle size between about 1 and 150 microns in diameter.
Type:
Grant
Filed:
March 2, 2000
Date of Patent:
July 3, 2001
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
Abstract: The invention relates to new diphenyl-substituted 5-ring heterocycles of general formula (I)
wherein A, X and the groups R1, R2, R3, R4 and R5 are defined as in the claims, processes for preparing them and their use as pharmaceutical compositions.
Type:
Grant
Filed:
April 13, 1999
Date of Patent:
July 3, 2001
Assignee:
Boehringer Ingelheim Pharma KG
Inventors:
Michael Brenner, Wolf-Dietrich Bechtel, Rainer Palluk, Marion Wienrich, Thomas Weiser, Enzo Cereda, Maura Bignotti, Carlo Maria Pellegrini
Abstract: The invention provides a process for coating a branded pharmaceutical dosage form for the purpose of covering any embossed or printed matter or any colored coating by the application of an amount of a sugar based coating which is sufficient to obscure any identifying indicia without compromising the stability or releasability of the drug that is contained in the dosage form.
Type:
Grant
Filed:
January 28, 2000
Date of Patent:
July 3, 2001
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
Abstract: The present invention relates to N-(5-phenyl-tetrahydrofuranyl)methyl- and N-(6-phenyl-tetrahydropyranyl)methyl-substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols of general formula 1, processes for preparing such compounds, pharmaceutical compositions containing such compounds and methods for using such compounds for the treatment of various diseases caused by a functional disorder resulting from overstimulation.
Type:
Grant
Filed:
February 22, 2000
Date of Patent:
June 12, 2001
Assignee:
Boehringer Ingelheim Pharma KG
Inventors:
Matthias Grauert, Hans Briem, Matthias Hoffmann, Adrian Carter, Thomas Weiser, Wolf-Dietrich Bechtel, Rainer Palluk
Abstract: A compound of formula I
wherein R1 is hydrogen, methyl, ethyl, methoxy or methylthio; R2 and R3 each independently is hydrogen or lower alkyl; R4 is hydrogen, lower alkyl, methoxy, ethoxy or benzyloxy; R5 is lower alkyl, lower cycloalkyl, (CH2)mC(O)OR6 wherein m is the integer 1 or 2 and R6 is lower alkyl, phenyl optionally substituted; optionally Het or Het(lower alkyl); or R4 and R5 together with the nitrogen atom to which they are attached form a nitrogen containing ring optionally substituted with C(O)O-benzyl or with phenyl optionally substituted with C(O)OR7 wherein R7 is lower alkyl or (lower alkyl)phenyl; and Z is lower alkyl or optionally substituted phenyl or Het; with the proviso that when Z is (CH2)p-(Het), then R2 and R3 each is hydrogen; or a therapeutically acceptable acid addition salt thereof which compound is useful in the treatment of HCMV infections.
Type:
Grant
Filed:
October 6, 1998
Date of Patent:
June 5, 2001
Assignee:
Boehringer Ingelheim (Canada) Ltd.
Inventors:
Christiane Yoakim, Robert Déziel, Jeffrey O'Meara, William W. Ogilvie
Abstract: A compound of formula 1:
wherein Y is S or O;
R1 is C1-6 alkyl; (C0-6 alkyl)aryl; (C0-6 alkyl)Het; or
R1 is an amino acid analog or dipeptide analog of the formula:
wherein R2 is H, C1-10 alkyl; or an amide or ester group;
A is C6-10 aryl, Het or CH—R3 wherein R3 is C1-6 alkyl or (C0-4 alkyl)aryl; and
Z is H, C1-6 alkyl, or an acyl;
R4 is hydrogen, lower alkyl, methoxy, ethoxy, or benzyloxy; and
R5 is alkyl, cycloalkyl, carboxyl group; an aryl;
Het or Het(lower alkyl); or R4 and R5 together with the nitrogen atom to which they are attached form a nitrogen containing ring optionally substituted with phenyl or C(O)OCH2-phenyl, said phenyl ring optionally mono- or
di-substituted with among others C(O)OR7 wherein R7 is lower alkyl or phenyl(lower alkyl); or a therapeutically acceptable acid addition salt thereof which compounds are useful in the treatment of HCMV infections.
Type:
Grant
Filed:
October 6, 1998
Date of Patent:
May 29, 2001
Assignee:
Boehringer Ingelheim (Canada) Ltd.
Inventors:
Eric Malenfant, Jeffrey O'Meara, Robert Déziel, William W. Ogilvie
Abstract: Disclosed are compounds which are neurokinin (tachykinin)-antagonists, useful for the treatment or prevention of inflammatory and allergic disease.
Type:
Grant
Filed:
December 1, 1999
Date of Patent:
May 15, 2001
Assignee:
Boehringer Ingelheim KG
Inventors:
Franz Esser, Gerd Schnorrenberg, Hans-Peter Ignatow, Günther Giesler, Birgit Jung, Georg Speck