Abstract: New pyridyl derivatives of the formula ##STR1## wherein R.sub.1 to R.sub.6, A, X and n are as defined herein, the enantiomers thereof, the cis- and trans-isomers thereof if R.sub.4 and R.sub.5 together represent a carbon-carbon bond, and the addition salts thereof. The new pyridyl derivatives have antithrombotic activity and thromboxane-mediated activities. The new compounds are also simultaneously thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH). They also have an effect on PGE.sub.2 -production.
Type:
Grant
Filed:
January 19, 1993
Date of Patent:
February 15, 1994
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Rainer Soyka, Wolfgang Eisert, Thomas Mueller, Johannes Weisenberger
Abstract: An apparatus for forming depressions in thermoplastic film. The apparatus uses rotating dies to first frictionally heat and soften the film, and to then urge the film into bores in a mold, thereby forming the depressions. The plastic films thus produced are useful in the production of packaging.
Abstract: Disclosed herein are peptide derivatives which inhibit the activities of human immunodeficiency virus (HIV) protease and renin. The peptide derivatives can be represented by general formula R.sup.1 --R.sup.2 --Y--R.sup.3 --R.sup.4 wherein R.sup.1 is a derived amino acid based on an O.sup.4 -(carboxymethyl)-tyrosyl residue, R.sup.2 and are amino acid or analogous amino acid residues (R.sup.3 may optionally be absent), Y is a non-peptide linking unit, e.g. statyl, and R.sup.4 is [--NR.sup.17 CHR.sup.18 --C(O)].sub.p --Z wherein R.sup.17 is hydrogen or lower alkyl, R.sup.18 is an amino acid or analogous amino acid side chain, p is zero or one and Z is a terminal group (e.g. hydroxy or amino), or R.sup.4 is --NR.sup.17 CR.sup.18 (R.sup.21)CH.sub.2 OH wherein R.sup.17 and R.sup.18 are as noted hereinabove and R.sup.21 is hydrogen, lower alkyl or hydroxy(lower)alkyl. The derivatives are useful as agents for combatting HIV infections and for treating renin-associated hypertension and congestive heart failure.
Type:
Grant
Filed:
June 6, 1989
Date of Patent:
June 30, 1992
Assignee:
Bio-Mega, Inc.
Inventors:
Paul C. Anderson, Yvan Guindon, Christiane Yoakim
Abstract: The invention relates to a method of separation by liquid chromatography for preparing enantiomerically pure hetrazines, using cellulose triacetate as a stationary phase and a polar solvent as a mobile phase.
Abstract: A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).
Type:
Grant
Filed:
November 21, 1986
Date of Patent:
September 26, 1989
Assignee:
American Cyanamid Company
Inventors:
Jane P. Kirby, Donald B. Borders, May D. Lee, William M. Maiese, Raymond T. Testa, David P. Labeda
Abstract: The invention relates to new compounds of general formula ##STR1## wherein R.sub.1 represents an alkyl group,R.sub.2 represents a hydrogen atom, an alkyl group optionally substituted (except at the .alpha. carbon atom) by a hydroxy group, or represents a cycloalkyl group or an allyl, phenyl or benzyl group,R.sub.3 represents an allyl group, an alkyl group optionally substituted (except at the .alpha. carbon atom) by a hydroxy group, or represents a cycloalkyl group orR.sub.2 and R.sub.3 together with the nitrogen atom between them represent a straight-chained alkyleneimino group,the acid addition salts thereof, particularly the acid addition salts thereof with physiologically acceptable inorganic or organic acids which have valuable pharmacological properties, particularly a metastasis-inhibiting effect based on their selective tumour-PDE inhibiting effect, and pharmaceutical compositions containing these compounds or the physiologically acceptable acid addition salts thereof.
Type:
Grant
Filed:
June 17, 1985
Date of Patent:
December 22, 1987
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Josef Roch, Armin Heckel, Josef Nickl, Erich Muller, Berthold Narr, Rainer Zimmermann, Johannes Weisenberger
Abstract: This invention concerns stabilized influenza virus vaccines and a method of stabilizing influenza viruses and vaccines by the addition of protein hydrolysates and/or amino acids.
Abstract: This invention is concerned with a low bulk density lyophilized pharmaceutical parenteral dosage unit of Sodium Piperacillin and method of making same.