Abstract: Transmissible spongiform encephalopathies (TSEs) are a class of fatal, neurodegenerative diseases found in many mammalian species. Human TSEs include kuru, Creutzfeldt-Jakob disease (CJD), and fatal familial insomnia. Non-human TSEs include sheep scrapie, bovine spongiform encephalopathy (BSE), feline spongiform encephalopathy, and chronic wasting diseases in elk and mule deer. These neurodegenerative diseases are caused by prions and display characteristic amyloid plaque deposition. The only known component of the infectious prion is an abnormal, disease-causing isoform of the prion protein (PrP), called PrP scrapie (PrPSc). During a post-translational process, PrPSc is formed from the normal, cellular PrP isoform (PrPC). The scrapie isoform is less soluble, more proteinase-resistant, and more susceptible to aggregation than the wildtype protein.

Abstract: The invention provides a coated tablet, a coating composition and a method of film coating. The coating is particularly useful for pharmaceutical tablets. The coating composition is composed of an aqueous solution of film forming inorganic salts which may be used with conventional coating techniques. Such film forming salts include sodium polyphosphate and sodium sulfate. This coating may be used on uncoated tablet cores, as a final coating or used as a subcoating for other coatings, such as enteric coatings. Use of this coating composition provides savings in cost of materials and in manufacturing efficiency over previous polymeric cellulose coatings.

Abstract: This invention provides a taste masking composition composed of clove oil and either supportive flavor components or calcium carbonate. This taste masking composition has been found to be particularly useful to mask unpalatable medicinals in formulations which are intended to be chewed, dissolve in the mouth prior to ingestion or ingested in solution.

Abstract: The invention discloses a swallow tablet which is capable of disintegrating within less than about fifteen minutes and providing fast delivery of therapeutic drugs. The delivery system is composed of between 0.250 and 1.0 Gm of an alkali metal or alkaline-earth metal salt of an edible organic acid. A preferred delivery system is trisodium citrate.

Abstract: The present invention is directed to a modular bottle dispenser apparatus used for dispensing bottles. Each dispenser includes a receiver opening, a dispenser opening, a continuous guide channel which restricts the side to side and up and down motion of a bottle as it moves from the receiver opening to the dispenser opening, a friction reducing member and a door that covers the receiver opening. Several dispensers can be interlocked to each other through interlocking members provided by the dispenser. The interlocking of several dispenser allows the display of various products in one contiguous setting.

Abstract: This invention provides an improved method for recovering an organic acid as a salt from various process streams by addition of a crystallizing base to a concentrated solution of neutralized organic acid. The addition of such a base causes crystallization of the salt. This process provides more efficient recovery of organic acid salt from a fermentation process stream than traditional crystallization and it may be used essentially as a one step purification process. The improved method is particularly applicable to the recovery of trisodium or tripotassium citrate from process streams produced in the fermentation and recovery of citric acid, with the addition of a crystallizing base such as sodium hydroxide, sodium carbonate, potassium hydroxide, or ammonia. The resulting product may be combined with an anticaking agent and/or dried to provide a particularly free flowing product.

Abstract: The invention discloses a swallow tablet which is capable of disintegrating within less than about fifteen minutes and providing fast delivery of therapeutic drugs. The delivery system is composed of between 0.250 and 1.0 Gm of an alkali metal or alkaline-earth metal salt of an edible organic acid. A preferred delivery system is trisodium citrate.

Abstract: This invention provides an improved method for recovering an organic acid as a salt from various process streams by addition of a crystallizing base to a concentrated solution of neutralized organic acid. The addition of such a base causes crystallization of the salt. This process provides more efficient recovery of organic acid salt from a fermentation process stream than traditional recrystallization and it may be used essentially as a one step purification process. The improved method is particularly applicable to the recovery of trisodium or tripotassium citrate from process streams produced in the fermentation and recovery of citric acid, with the addition of a crystallizing base such as sodium hydroxide, potassium hydroxide or ammonia.

Abstract: The invention discloses an aqueous granulating solution containing sodium, potassium or mixed sodium potassium salt of an edible organic acid selected from the group consisting of citric, malic, tartaric and fumaric acid and optionally containing sodium or potassium bicarbonate. The granulating solution is especially useful for granulating finely divided solids including acetaminophen, ketoprofen or calcium carbonate. The resulting granulate may be used to prepare a swallow tablet or mixed with an edible organic acid and the mixture tableted to provide an effervescent tablet without resorting to controlled reaction or special handling techniques.

Abstract: Disclosed are compositions of particulate citric acid or an alkali metal or alkaline earth metal salt thereof prepared by an improved method and an improved method of preparing a detergent builder composition. The method of preparing particulate citric acid or salts thereof involves spray granulating citric acid or a salt thereof from its partially purified fermentation broth to form granules which are freer flowing and less inclined to fracture than is citric acid or its salts prepared by crystallization techniques which properties render the material prepared by the present method suitable for handling in bulk. The same properties may be imparted to detergent builder compositions by adding detergent builders to the partially purified fermentation broth or by introducing a detergent builder solution into a fluidized bed reactor together with appropriate seed particles to thereby form granules which include such detergent builders.

Abstract: Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The derivatives have a general formula I ##STR1## in which X is --S--,W is CH.dbd.CH;o is 1 to 4;n is 2 to 6;m is 0 to 2;T and Z, same or different, represent oxygen or a direct bond;R.sup.2 and R.sup.3, represent hydrogen, or fluorine;A represents carboxyl, CO.sub.2 R.sub.4.sup.4, wherein R.sup.4 is lower alkylR is ##STR2## wherein Y represents carboxyl, CO.sub.2 R.sup.4, wherein R.sup.4 is lower alkylR.sup.7 and R.sup.8, same or different, represent H or lower alkyl;R.sup.9 represents --OH, --O-alkyl, NH.sub.2 or a NHCH.sub.2 CO.sub.2 H group; andR.sup.10 R3 is H.

Abstract: The invention involves a granulating composition composed of an aqueous solution of magnesium sulfate heptahydrate and sodium hexametaphosphate. This composition can be used to prepare granules of ingredients for inclusion in any formulation for which rapid disintegration or dispersion are important factors. It is useful for tablets containing ingredients which are difficult to compress and is particularly useful for formulating swallowable tablets of a single non-soluble ingredient such as calcium carbonate. Disintegration times are markedly decreased.

Abstract: The invention discloses an antimicrobial composition composed of an antimicrobial polypeptide and a hypothiocyanate component. Synergistic activity is seen when the composition is applied at between about 30 and 40 degrees Centigrade at a pH between about 3 and about 5. The composition is useful against gram negative bacteria such as Salmonella. A preferred composition is nisin, lactoperoxidase, thiocyanate and hydrogen peroxide. Such a composition is capable of reducing the viable cell count of Salmonella by greater than 6 logs in 10 to 20 minutes.

Abstract: The invention involves a granulating composition composed of an aqueous solution of magnesium sulfate heptahydrate and sodium hexametaphosphate. This composition can be used to prepare granules of ingredients for inclusion in any formulation for which rapid disintegration or dispersion are important factors. It is useful for tablets containing ingredients which are difficult to compress and is particularly useful for formulating swallowable tablets of a single non-soluble ingredient such as calcium carbonate. Disintegration times are markedly decreased.

Abstract: A method and composition for providing aspartame as a sweetener in effervescent calcium ion-generating systems is provided. The method includes a step for providing a selected surfactant in association with the aspartame sweetener, to provide for aqueous solution of the aspartame in the presence of the solubilized calcium without film formation and without excessive foaming. Preferably, the aspartame/surfactant is provided by a granule composition, utilized in association with a calcium carbonate/citric acid effervescent couple.

Abstract: A method of increasing the yield of plasminogen activator from a plasminogen activator-producing cell line by adapting said cell line to grow in a suitable growth medium essentially free of fetal calf serum is disclosed. Also disclosed are cell lines capable of producing relatively large quantities of plasminogen activator, and a chemically defined growth medium suitable for adapting a plasminogen activator-secreting cell line to growth in the absence of fetal calf serum.

Abstract: A stable test device for the determination of a peroxidatively active substance comprising a carrier containing 1,4-diisopropylbenzene dihydroperoxide and a benzidine indicator in a molar ratio of from 0.9 to 3.0. The composition can be incorporated in a carrier matrix along with a ferric chelate to provide ascorbate resistance thereto, which is important in a urine test for occult blood. The test device is stable under storage and heat stress and can be used to prepare a multitest strip containing a glucose test based on a peroxidase/potassium iodide indicator system.

Abstract: A therapeutic method for producing bronchodilation in an individual for whom such therapy is indicated is disclosed. The method comprises administering to said individual an effective bronchodilation amount of certain derivatives of 15-deoxy-16-hydroxy-prostaglandin E.sub.1 esters.

Abstract: A viability test device wherein the viability of a test composition for the determination of an analyte of interest can be determined by simply wetting the device with ordinary water. The viability device can be prepared in three formats: a control or calibrator device, an internal control device and a self indicating device. Unreacted analyte, or an analog thereof, can be incorporated in a limited defined portion of a dried carrier matrix incorporated with a test composition to provide an internal control test device. When wetted with water, a positive optical response, usually color, indicates the test composition can provide a viable test for the analyte. The internal control test device is particularly advantageously used by diabetics in their own homes where a negative test response could be due to the desired control of the user's condition or due to deterioration of a test composition because of unfavorable storage conditions.

Abstract: A test means for determining the presence of an ion in an aqueous test sample is disclosed, as well as a test device incorporating the test means, a method for preparing it and a method for using it. The test means is composed of a porous carrier matrix incorporated, substantially uniformly, with a homogeneous hydrophobic composition and with a buffering substance capable of providing a pH in the range of from about 5 to 10. The homogeneous hydrophobic composition contains an ionophore capable of forming a complex with the ion, a hydrophobic substance and a reporter substance capable of interacting with the complex of ionophore and ion to produce a detectable response. In a preferred embodiment, this invention provides a colorimetric test capable of measuring serum potassium.