Patents Represented by Attorney Mary J. Morry

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  • 2',3'-dideoxy-2'-fluoro-purine nucleosides and methods for using same
    Patent number: 5565437
    Abstract: Methods of treating a human infected with human immunodeficiency virus (HIV), such as a human with AIDS, with the purina nucleotides 2',3'-dideoxy-2'-beta-fluoroadenosine (FddA) and 2',3'-dideoxy-2'-beta-fluoroinosine (FddI) are disclosed. These nucleotides are stable in an acid environment and thus can be used for oral administration. Methods of inhibiting human immunodeficiency virus replication in a human T cell using these purina nucleotides are also disclosed.
    Type: Grant
    Filed: November 10, 1992
    Date of Patent: October 15, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Victor E. Marquez, John S. Driscoll, Christopher K-H. Tseng, James A. Kelley, David G. Johns, Hiroaki Mitsuya
  • Acid stable purine dideoxynucleosides
    Patent number: 5495010
    Abstract: Purine nucleosides active against human immunodeficiency virus which are substituted at the 2'-position by a strong electronegative group such as fluorine are stable in an acid environment and thus can be used for oral administration.
    Type: Grant
    Filed: September 19, 1991
    Date of Patent: February 27, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Victor E. Marquez, John S. Driscoll, Christopher K-H. Tseng, James A. Kelley, David G. Johns, Hiroaki Mitsuya
  • Methods of using labeled nucleotides
    Patent number: 5328824
    Abstract: Compounds having the structure: ##STR1## wherein B represents a purine, 7-deazapurine, or pyrimidine moiety covalently bonded to the C.sup.1' -position of the sugar moiety, provided that when B is purine or 7-deazapurine, it is attached at the N.sup.9 -position of the purine or 7-deazapurine and when B is pyrimidine, it is attached at the N.sup.
    Type: Grant
    Filed: December 8, 1987
    Date of Patent: July 12, 1994
    Assignee: Yale University
    Inventors: David C. Ward, Pennina R. Langer, Alexander A. Waldrop, III
  • Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
    Patent number: 5272065
    Abstract: Gene expression in a cell can be regulated or inhibited by incorporating into or associating with the genetic material of the cell a non-native nucleic acid sequence which is transcribed to produce an mRNA which is complementary to and capable of binding to the mRNA produced by the genetic material of said cell.
    Type: Grant
    Filed: June 21, 1990
    Date of Patent: December 21, 1993
    Assignee: Research Foundation of State University of New York
    Inventors: Masayori Inouye, Takeshi Mizuno, Mei-Yin Chou
  • Nucleic acid constructs containing stable stem and loop structures
    Patent number: 5208149
    Abstract: Gene expression in a cell can be regulated or inhibited by incorporating into or associating with the genetic material of the cell a non-native nucleic acid sequence which is transcribed to produce an mRNA which is complementary to and capable of binding to the mRNA produced by the genetic material of said cell.
    Type: Grant
    Filed: April 10, 1992
    Date of Patent: May 4, 1993
    Assignee: The Research Foundation of State University of New York
    Inventor: Masayori Inouye
  • Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
    Patent number: 5190931
    Abstract: Gene expression in a cell can be regulated or inhibited by incorporating into or associating with the genetic material of the cell a non-native nucleic acid sequence which is transcribed to produce an mRNA which is complementary to and capable of binding to the mRNA produced by the genetic material of said cell.
    Type: Grant
    Filed: November 15, 1989
    Date of Patent: March 2, 1993
    Assignee: The Research Foundation of State University of New York
    Inventor: Masayori Inouye