Abstract: Disclosed are 14-aminosteroid compounds, including pharmaceutically acceptable acid salts and esters thereof, useful in treating individuals afflicted with congestive heart failure, which compounds have the general formula: ##STR1## wherein R.sub.3 is a deoxy or oxygen-substituted monosaccharide sugar residue and R.sub.1, R.sub.2 and R.sub.4 are various other substituents as defined herein.

Abstract: The present invention relates to oligosaccharide-containing 14-aminosteroid compounds and the pharmaceutically-acceptable acid salts or esters thereof of the general formula: ##STR1## wherein a) R.sub.1 is(i) COOR.sub.5, whereR.sub.5 is hydrogen, a 1-6 carbon lower alkyl; a 1-6 carbon lower alkyl substituted by an amino group; an arylalkyl or heteroarylalkyl or a carbocyclic ring, or(ii) CHR.sub.6 OH, whereR.sub.6 is a hydrogen atom or 1-6 carbon lower alkyl group, or(iii) COR'", where R'" is hydrogen; 1-6 carbon lower alkyl; 1-6 carbon lower alkyl substituted amino; amino or dialkylamino; andb) R.sub.2 is --NR.sub.7 R.sub.8, whereR.sub.7 and R.sub.8, which may be the same or different, are hydrogen atoms or a 1-6 carbon lower alkyl; andc) R.sub.3 is an oligosaccharide sugar residue; andd) R.sub.4 is(i) OH, or(ii) H, or(iii) OR.sub.13, whereR.sub.13 is a monosaccharide sugar residue; acetoxy; benzoxy; arylalkyl or heteroarylalkyl; ande) Z is(i) --CH--, wherea and b are single bonds, or(ii) .dbd.

Abstract: The present invention provides a process for making a compound having a structure according to Formula (I) ##STR1## wherein A.sup.1, A.sup.2 and A.sup.3 are independently carbon or nitrogen and R.sup.1, R.sup.3, R.sup.4 and R.sup.6 are known quinolone substituents; and wherein one of R.sup.1, R.sup.3 or R.sup.6 may be a lactam-containing moiety;or a protected form, salt, pharmaceutically-acceptable salt, biohydrolyzable ester, or solvate thereof;the process comprising reacting one or more organosilicon compounds with a compound having a structure according to Formula (II) ##STR2## wherein A.sup.1, A.sup.2 and A.sup.3, R.sup.1, R.sup.3, R.sup.4 and R.sup.6 as described above; wherein one of R.sup.1, R.sup.3 or R.sup.6 may be a lactam-containing moiety; and X is a leaving group;or a protected form, salt, biohydrolyzable ester, or solvate thereof.

Abstract: A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3;(b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen;(e) W is hydrogen or straight, branched or cyclic alkyl, aryl, hydroxy or alkoxy; and(f) R.sub.1 and R.sub.2 are independently hydrogen or straight, branched or cyclic alkyl having from one to 10 carbon atoms, aryl, heterocyclyl, heteroaryl, hydroxy, or alkoxy; or R.sub.1 and R.sub.2 are bonded together to form a ring having from from 3 to about 7 atoms wherein one to three atoms may be heteroatoms.pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Abstract: A process for the manufacture of a high bulk density granular dishwashing detergent composition which comprises agglomerating ingredients with a liquid binder to form base granules which are substantially free of alkali metal silicates followed by admixing alkali metal silicate. The process provides uniform delivery of detergent ingredients and improved solubility.

Abstract: Liquid or granular automatic dishwashing detergent compositions comprising builder, enzyme and low molecular weight modified polyacrylate copolymers for enhanced hard water filming and enzyme performance.

Abstract: Liquid or gel dishwashing detergent compositions containing anionic surfactant, polyhydroxy fatty acid amide, calcium ions and alkyl polyethoxypol ycarboxylate for improved stability are described. A preferred embodiment comprises:(a) from about 3% to about 40% of polyhydroxy fatty acid amide having the formula: ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-4 hydrocarbyl, 2-hydroxyethyl, 2-hydroxypropyl, or mixtures thereof; R.sup.2 is C.sub.5 -C.sub.31 hydrocarbyl; mid Z is a polyhydroxy-hydrocarbyl having a linear hydrocarbyl chain with at least three hydroxyl groups directly connected to the chain, or an alkoxylated derivative thereof;(b) from about 0.1% to about 4% of calcium ions;(c) from about 0.001% to about 15% of alkylpolyethoxypolycarboxylate surfactant having the general formula: ##STR2## wherein R is a C.sub.6 to C.sub.18 alkyl group, x is from about 1 to about 25, R.sub.1 and R.sub.

Abstract: A process for preparing viscoelastic, thixotropic, liquid, polymer-containing detergent compositions which exhibit increased density, enhanced aesthetics and improved rheological efficiency of the polymer is provided. The polymer thixotropic thickening agent is simultaneously added and mixed as a slurry to a premix under moderate to high shear rate to neutralize and disperse the polymer. The product is deaerated to increase density and enhance aesthetics by continued mixing under low to moderate shear rate of the slurry/premix composition. Sequential addition and mixing to the slurry/premix of organic solvent, oil, suds suppressors and solid material can aid in the deaeration step.

Abstract: The subject invention relates to compounds having the structure: ##STR1## wherein (a) X is selected from hydroxy, C.sub.1 to about C.sub.2 alkanoxy, thiol, C.sub.1 to about C.sub.2 alkanylthiol, and halo;(b) R and R' are each independently selected from C.sub.1 to about C.sub.3 straight or branched alkanyl, and C.sub.3 to about C.sub.4 cyclic alkanyl; or R and R' are bonded together to form a C.sub.3 to about C.sub.6 cyclic alkanyl ring, or a C.sub.3 to about C.sub.5 cyclic heteroalkanyl ring having one oxygen or sulfur atom in the ring, the heteroatom not being bonded to the carbon to which X is bonded; and R and R', or the ring formed by them when bonded together, are each, independently, unsubstituted or monosubstituted with a substituent selected from halo, hydroxy, thiol, C.sub.1 to about C.sub.2 alkanoxy, and C.sub.1 to about C.sub.2 alkanylthiol.The subject invention also relates to the pharmaceutical compositions comprising the above compounds, and methods of treating inflammation using the compounds.

Abstract: Concentrated Liquid or gel dishwashing detergent compositions containing high active levels of surfactant, calcium ions and disulfonate surfactant are disclosed. The compositions exhibit improved stability as well as providing good cleaning and grease removal benefits. Particularly preferred compositions also contain simple sugars.

Abstract: Concentrated liquid or gel dishwashing detergent compositions containing from about 20% to about 95% surfactant and calcium ions. A substantial amount of the calcium ions is added as calcium xylene sulfonate for improved stability of the composition.

Abstract: Light duty liquid or gel dishwashing detergent compositions containing high active levels of surfactant, magnesium and sugar are disclosed. The compositions exhibit improved product stability and dissolution in wash water.

Abstract: A light-duty liquid or gel dishwashing detergent composition containing an alkyl ethoxy carboxylate surfactant mixture and calcium ions. The composition may require a calcium chelating agent, particularly at pH levels above 9, to prevent the formation of CaCO.sub.3 precipitates during storage. The compositions exhibit good grease removal, mildness to the skin, and storage stability.

Abstract: A light-duty liquid or gel dishwashing detergent composition containing an alkyl ethoxy carboxylate surfactant, magnesium ions, a magnesium chelating agent, and a buffering agent to maintain the pH of the composition from about 8 to 10. High pH and magnesium ions of the composition provide good grease removal properties while maintaining mildness to the skin. The buffering agent and chelating agent of the composition provide superior physical and chemical stability during storage. The preferred type of dishwashing detergent composition is in the liquid form.

Abstract: A method for preparing a free flowing perfume capsule composition with enhanced performance and stability from slurries containing perfume capsules is described. A process comprising removing water from the slurry to form a wet cake, combining silicone dioxide or aluminosilicate to the wet cake to fluidize the wet cake and removing additional water from the fluidized wet cake to form free flowing perfume capsules is preferred.

Abstract: A process for preparing polyhydroxy fatty acid amide compositions which are pumpable at temperatures between about 70.degree. F. (21.1.degree. C.) and about 120.degree. F. (48.9.degree. C.) by adding certain soluble inorganic salts or salts of C.sub.1-3 carboxylic acids to a heated polyhydroxy fatty acid amide preparation.

Abstract: Liquid or gel dishwashing detergent compositions containing alkyl amphocarboxylic acid and magnesium or calcium ions for improved stability, sudsing and grease cleaning are described. Stable liquid detergent compositions containing alkyl amphodicarboxylic acid, and magnesium ions are preferred.

Abstract: Solid peroxygen bleach containing aqueous liquid detergent compositions having a pH of at least 8 are disclosed. The peroxygen bleach is water-soluble.The liquid detergent composition comprises a solvent system comprising water and a water-miscible solvent. The solvent system provides sufficient solubility of anionic surfactants, while keeping the solubility of the peroxygen bleach compound within defined limits.

Abstract: Stable colorless detergent compositions are provided comprising anionic and/or nonionic surfactant, oxygen bleach and metal sequestering agent. The compositions do not discolor over time or under harsh temperatures.

Abstract: The present invention provides a deterent composition comprising:(a) at least 0.1% of an oleoyl sarconsinate of the formula: ##STR1## wherein M is hydrogen or a cationic moiety; and (b) from about 0.05% to about 15% of a polymeric dispersing agent selected from the group selected from the group consisting of polycarboxylates, polyethylene glycol polymers, polyaspartates and mixtures thereof.