Abstract: A compound having the structure: ##STR1## wherein (a) X is oxygen or sulfur;(b) each Y is independently hydrogen or unsubstituted straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms, or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms;(c) Z is hydrogen or unsubstituted branched or cyclic alkyl, or unsubstituted or alkanyl-substituted phenyl, having from 3 to about 10 atoms other than hydrogen;(d) W is straight, branched or cyclic alkyl or aryl, unsubstituted or substituted, saturated or mono- or di-unsaturated with double bonds except that no terminal carbon atom of W is part of a double bond; W having from 1 to about 15 atoms other than hydrogen; pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
October 7, 1997
Assignee:
The Procter & Gamble Company
Inventors:
Michael Wiard Scherz, Randall Stryker Matthews
Abstract: The subject invention relates to compounds having the structure: ##STR1## wherein (a) n is an integer from 1 to about 3;(b) X and Y are each independently selected from O, S and CH.sub.2, with at least one of X and Y being O or S;(c) R is unsubstituted, straight or branched chain alkanyl or alkanoxy having from 1 to about 3 non-hydrogen atoms; and(d) R' is selected from hydrogen, methyl, cyano, and halo; pharmaceutical compositions containing such compounds; and the use of such compounds for preventing or treating one or more of respiratory disorders, ocular disorders, and gastrointestinal disorders.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
September 2, 1997
Assignee:
The Procter & Gamble Company
Inventors:
Peter Julian Maurer, Jeffrey Joseph Ares, William Lee Seibel, Daniel P. Walker
Abstract: Automatic dishwashing detergent compositions comprising a diacyl peroxide particle are disclosed. The diacyl peroxide particles are premixed with dispersing agent prior to the addition of other automatic dishwashing detergent ingredients. The dispersing agent is selected from the group consisting of surfactants, dispersant polymers and mixtures thereof. The compositions are effective in removing carotenoid stains from plastics and tea stains from china under various temperature and pH conditions.
Abstract: A compound having the structure: ##STR1## wherein (a) X is oxygen or sulfur;(b) each Y is independently hydrogen or unsubstituted straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms,. or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms;(c) Z is hydrogen or unsubstituted branched or cyclic alkyl, or unsubstituted or alkanyl-substituted phenyl, having from 3 to about 10 atoms other than hydrogen;(d) W is straight, branched or cyclic alkyl or aryl, unsubstituted or substituted, saturated or mono- or di-unsaturated with double bonds except that no terminal carbon atom of W is part of a double bond; W having from 1 to about 15 atoms other than hydrogen;pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
August 12, 1997
Assignee:
The Procter & Gamble Company
Inventors:
Michael Wiard Scherz, Randall Stryker Matthews
Abstract: A disposable article having a void area for isolation of fecal material is disclosed. The void is created by having a split absorbent core and at least one elastically extendible topsheet/backsheet panel proximate to the split. The void is created and adjusted by the amount of extension of the topsheet/backsheet proximate to the split.
Abstract: A compound having the structure: ##STR1## pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
Abstract: A process for preparing a granular automatic dishwashing detergent composition with improved solubility which comprises incorporating low foaming nonionic surfactant with a melting point between about 77.degree. F. (25.degree. C.) and about 140.degree. F. (60.degree. C.) into alkali metal silicate particles, and admixing the silicate with substantially silicate free base granules.
Abstract: Mild detergent compositions which exhibit good cleaning performance comprise detergent surfactants and small amounts of protease. A preferred embodiment additionally contains suds boosters and divalent ions.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
February 4, 1997
Assignee:
The Procter & Gamble Company
Inventors:
Mark H. Mao, Janet L. Marshall, Martha O. Visscher
Abstract: The subject invention relates to compounds having the structure: ##STR1## wherein: (a) R is unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl;(b) R' is selected from unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl; unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; hydroxy; thiol; and halo; and(c) R" is selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl; methyl monosubstituted with hydroxy, thiol or amino; unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; amino; unsubstituted amide; unsubstituted or C.sub.1 -C.sub.3 substituted amido; halo; unsubstituted sulfoxide; unsubstituted sulfonyl; and cyano;pharmaceutical compositions containing such compounds, and the use of such compounds for preventing or treating respiratory, ocular, and/or gastrointestinal disorders.
Type:
Grant
Filed:
October 20, 1994
Date of Patent:
November 26, 1996
Assignee:
The Procter & Gamble Company
Inventors:
Thomas L. Cupps, Peter J. Maurer, Jeffrey J. Ares
Abstract: There is provided a rinse aid composition containing a chelant component selected from ethylenediamine disuccinic acid ethylenediamine diglutaric acid (EDDG), 2 hydroxypropylenediamine-disuccinic acid (HPDDS) or any of the salts or complexes of said chelant components. The pH of said composition as a 1% solution in distilled water at 20.degree. C. is preferably less than 7.
Abstract: There is provided a rinse aid composition containing an organo aminophosphonic acid or its salts or complexes. The pH of said composition as a 1% solution in distilled water at 20.degree. C. is preferably less than 7.
Abstract: The present invention relates to novel heterocycle-substituted diphosphonic acids, and the pharmaceutically-acceptable salts and esters thereof, in which the diphosphonate-substituted carbon atom moiety is attached to a carbon atom in a nitrogen-containing six membered ring heterocycle, preferably a piperidine ring. The heterocycle-substituted diphosphonic acid compounds have the general structure: ##STR1## wherein Z is a nitrogen-containing six membered ring heterocycle moiety selected from piperidinyl, diazinyl and triazinyl; m, n and m+n are from 0 to 10; Q is a covalent bond or a moiety selected from oxygen, sulfur or nitrogen; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are substituent groups.The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.
Abstract: The subject invention relates to compounds having the structure: ##STR1## wherein a) each R is independently alkyl having from 1 to about 7 carbon atoms;b) Z is O or N--X;c) X is selected from hydrogen, alkyl having from 1 to about 7 carbon atoms, C(O)Y, C(S)Y, and SO.sub.2 Y;d) Y is selected from R', OR' and NR'.sub.2 ; ande) R' is selected from hydrogen, alkyl having from 1 to about 7 carbon atoms, and phenyl.The subject invention also relates to pharmaceutical compositions comprising the above compounds, and methods of treating inflammation or pain using the compounds.
Abstract: Liquid laundry detergent compositions containing anionic or nonionic surfactant, citric acid or a water-soluble salt thereof, proteolytic enzyme, cellulase, and a mixture of 1,2 propane diol and boric acid or its derivative. The compositions are prepared by adding the diol and boric acid before adding the citric acid/salt to the composition. This order of addition improves the stability of the cellulase.
Abstract: The present invention provides a detergent composition comprising:(a) at least 0.1% of an oleoyl sarcosinate of the formula: ##STR1## wherein M is hydrogen or a cationic moiety; and (b) from about 0.1% to about 20% of an amine oxide.