Patents Represented by Attorney Mary S. King
  • Patent number: 4474813
    Abstract: A pharmaceutical preparation comprising flutamide, useful in the treatment of prostatic carcinoma, is disclosed.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: October 2, 1984
    Assignee: Schering Corporation
    Inventors: Rudolph O. Neri, John G. Topliss
  • Patent number: 4423055
    Abstract: 6-Substituted-hydrocarbon-2-(substituted-thio)penem-3-carboxylic acids and congeners having useful antibacterial activity are disclosed. The compounds are prepared in a reaction sequence starting with a 4-acyloxy-2-azetidinone.
    Type: Grant
    Filed: November 23, 1981
    Date of Patent: December 27, 1983
    Assignee: Schering Corporation
    Inventor: Stuart W. McCombie
  • Patent number: 4374844
    Abstract: Sodium and Potassium (5R,6S,8R)-6-(1-hydroxyethyl)-2-ethylthiopenem-3-carboxylic acid exhibit potent, broad-spectrum antibacterial activity, are orally effective and chemically stable.
    Type: Grant
    Filed: October 30, 1981
    Date of Patent: February 22, 1983
    Assignee: Schering Corporation
    Inventor: Stuart W. Mc Combie
  • Patent number: 4361557
    Abstract: Described are D-(threo)-1-aryl-2-acylamido-3-fluoro-1-propanol esters and salts thereof, methods for their preparation, and methods for their use as antibacterial agents.
    Type: Grant
    Filed: August 10, 1981
    Date of Patent: November 30, 1982
    Assignee: Schering Corporation
    Inventor: Tattanhalli L. Nagabhushan
  • Patent number: 4352808
    Abstract: 3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl(benzo(b)thiophenes and related derivatives having antifungal, antibacterial, and antiprotozoal activity are prepared by the reaction of the corresponding 2,3-dihydro-3-hydroxy-2-(imidazolylmethyl)benzo(b)thiophene or related derivative and an aralkyl halide.Preferred compounds are those where the aralkyl function is a hetercyclic aromatic, particularly 2-chloro-3-thenyl, and where the benzene nucleus is substituted by chlorine or fluorine.Pharmaceutical formulations comprising compounds of this invention are described, as well as the method for their use in treating microbial infections.
    Type: Grant
    Filed: December 12, 1980
    Date of Patent: October 5, 1982
    Assignee: Schering Corporation
    Inventors: Dinanath F. Rane, John J. Wright, Russell E. Pike
  • Patent number: 4347183
    Abstract: Described is a novel process for the preparation of penems and carbapenems useful as antibacterial agents which comprises the reaction of an appropriate 4-substituted-azetidine-2-one with an acid halide in the presence of a tertiary amine and an alkaline earth metal carbonate, followed by reaction of the thereby formed 1-imido-4-substituted-azetidine-2-one with a trialkyl phosphite.Also described are novel penems useful as antibacterials which are prepared by the described process.
    Type: Grant
    Filed: February 2, 1981
    Date of Patent: August 31, 1982
    Assignee: Schering Corporation
    Inventors: Adriano Afonso, Frank Hon
  • Patent number: 4337335
    Abstract: Described are transition metal salt complexes of available neighboring amino and hydroxyl group pairs in polyamino organic compounds, their preparation, and use as intermediates in the preparation of selectively N-blocked polyamino organic compounds.
    Type: Grant
    Filed: December 26, 1979
    Date of Patent: June 29, 1982
    Assignee: Schering Corporation
    Inventors: Tattanahalli L. Nagabhushan, William N. Turner, Alan Cooper
  • Patent number: 4323512
    Abstract: 17-Arylcarboxylate esters of 9,11-unsubstituted 4-pregnene-17.alpha.,21-diol-3,20-diones are prepared by reaction of the corresponding 17.alpha.-hydroxy derivative with alkyl lithium and an anhydride or acyl halide reagent in the presence of 4-(di-lower alkyl)aminopyridine at low temperatures. A preferred mode of the process is the preparation of 16.beta.-methyl-1,4-pregnadiene-17.alpha.,21-diol3,20-dione 17.alpha.-m-iodobenzoate 21-benzoate, a valuable intermediate in the manufacture of betamethasone.
    Type: Grant
    Filed: May 13, 1981
    Date of Patent: April 6, 1982
    Assignee: Schering Corporation
    Inventors: Ronald C. D. Breslow, Craig S. Wilcox
  • Patent number: 4322434
    Abstract: N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto, useful as antihypertensive agents, are prepared by reaction of an N-substituted aniline with a polyfluoroacetone.
    Type: Grant
    Filed: January 22, 1981
    Date of Patent: March 30, 1982
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • Patent number: 4314942
    Abstract: An improved synthetic process for the removal of an allyl group in an allylic ester or an allyloxycarbonyl group in an allylic carbonate or carbamate by reaction with 2-ethylhexanoic acid or an alkali metal salt thereof and a catalytic amount of an organic-soluble palladium complex is disclosed herein.
    Type: Grant
    Filed: January 10, 1979
    Date of Patent: February 9, 1982
    Assignee: Schering Corporation
    Inventor: Stuart W. McCombie
  • Patent number: 4312863
    Abstract: Ophthalmic compositions containing (-)-5-{(R)-1-Hydroxy- 2[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamide and a method of using them in the treatment of glaucoma are disclosed.
    Type: Grant
    Filed: August 4, 1980
    Date of Patent: January 26, 1982
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Wei Chang
  • Patent number: 4311857
    Abstract: Described are D-(threo)-1-aryl-2-acylamido-3-fluoro-1-propanol esters and salts thereof, methods for their preparation, and methods for their use as antibacterial agents.
    Type: Grant
    Filed: April 4, 1980
    Date of Patent: January 19, 1982
    Assignee: Schering Corporation
    Inventor: Tattanahalli L. Nagabhushan
  • Patent number: 4304779
    Abstract: 6-(Heterocyclic)hydroxymethylpenicillanic acids and compounds related thereto are prepared by reaction of a 6,6-dihalopenicillanic acid with a Grignard reagent and a heterocyclic aldehyde in an anhydrous aprotic solvent. The compounds possess useful antibacterial activity.
    Type: Grant
    Filed: May 9, 1979
    Date of Patent: December 8, 1981
    Assignee: Schering Corporation
    Inventors: Patricia L. Cavender, Ashit K. Ganguly, Viyyoor M. Girijavallabhan
  • Patent number: 4304790
    Abstract: 2-(Alkylthio, alkylsulfinyl or alkylsulfonyl)-4-[2-(anilinoalkylamino)-1-hydroxyalkyl]phenols and derivatives thereof, particularly useful as agents for the treatment of hypertension, are disclosed herein.
    Type: Grant
    Filed: June 12, 1979
    Date of Patent: December 8, 1981
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • Patent number: 4299845
    Abstract: The present invention relates to topical compositions and methods of use utilizing compounds of the formula ##STR1## wherein X is oxygen or sulfur;W is a bridge group of the formulae ##STR2## wherein R is hydrogen alkyl of 1 to 7 carbon atoms, cycloalkyl of 4-8 carbon atoms, cycloalkenyl of 5-8 carbon atoms, polyfluoroalkyl of 1-4 carbon atoms, phenyl, benzyl or alkoxycarbonylmethyl; R.sub.1 is hydrogen or alkyl of 1-7 carbon atoms; m is 0-2; n is 1-4; with the proviso that m+n is 3-5; andA.sub.1, A.sub.2, A.sub.3, A.sub.4, B.sub.1, B.sub.2, B.sub.3, and B.sub.4 are independently selected from the group consisting of hydrogen, methyl, cyano, nitro, polyfluoroalkyl of 1-3 carbon atoms, chloro, bromo, fluoro and alkylthio, with the proviso that 2-5 of there are hydrogen of which at least one of A.sub.1, A.sub.2, A.sub.3 and A.sub.4 and at least one of B.sub.1, B.sub.2, B.sub.3 and B.sub.4 is hydrogen.
    Type: Grant
    Filed: April 14, 1980
    Date of Patent: November 10, 1981
    Assignee: Schering Corporation
    Inventors: David Loebenberg, Elijah H. Gold
  • Patent number: 4296242
    Abstract: This invention describes a novel process whereby D-glucose and D-mannose are converted to S-3-amino-2-hydroxypropionic acid and R-3-amino-2-hydroxypropionic acid, respectively, and their N-blocked derivatives.
    Type: Grant
    Filed: June 6, 1979
    Date of Patent: October 20, 1981
    Assignee: Schering Corporation
    Inventors: Tattanahalli L. Nagabhushan, Alan Cooper
  • Patent number: 4292323
    Abstract: This application relates to phenyl-substituted 1,2,3,4-tetrahydrocarbazoles and to their use as anti-depressant agents useful in the treatment of mental depression of either endogenous or reactive nature.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: September 29, 1981
    Assignee: Schering Corporation
    Inventor: Pirouz Tahbaz
  • Patent number: 4284764
    Abstract: A novel process whereby 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols are reacted with a dialkylaminosulfur trifluoride to produce novel 5-fluoro-5-deoxy and 5-epi-fluoro-5-deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitol antibacterial agents.
    Type: Grant
    Filed: February 19, 1980
    Date of Patent: August 18, 1981
    Assignee: Schering Corporation
    Inventors: Peter J. L. Daniels, Dinanath Rane
  • Patent number: 4283531
    Abstract: .beta.-Lactams having a substituted hydroxymethylene group at the position .alpha. to the lactam carbonyl group are prepared by reaction of an .alpha.-halo-.beta.-lactam with zinc or zinc amalgam in an anhydrous aprotic medium to produce an intermediate which in situ reacts with an appropriate aldehyde or ketone.Also described are novel penicillins and cephalosporins having useful antibacterial activity.
    Type: Grant
    Filed: October 4, 1979
    Date of Patent: August 11, 1981
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Viyyoor M. Girijavallabhan, Patricia Cavender, Olga Sarre, Stuart W. McCombie
  • Patent number: 4283528
    Abstract: 1-N-(R-.beta.-amino-.alpha.-hydroxypropionyl) gentamicin B, 1-N-(R-.gamma.-amino-.alpha.-hydroxybutyryl) gentamicin B, 1-N-(R-.delta.-amino-.alpha.-hydroxyvaleryl) gentamicin B and the corresponding diastereoisomers derived from the respective S-aminohydroxy acids and the acid addition salts thereof exhibit substantial antibacterial activity, especially against strains of bacteria which are resistant to gentamicin B and acid addition salts thereof.
    Type: Grant
    Filed: April 24, 1979
    Date of Patent: August 11, 1981
    Assignee: Schering Corporation
    Inventors: Peter J. L. Daniels, Tattanahalli L. Nagabhushan